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Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract

Tropical Animal Science Journal · Vol. 44 No. 4 (2021) · hlm. 415–424

DOI
10.5398/tasj.2021.44.4.415
ISSN
2615-790X, 2615-787X
Terbit
2021-11-12
Penerbit
Faculty of Animal Science, IPB University
Bahasa
eng

Abstrak

The study examined the effectiveness of ethyl-acetate fraction of Pelawan extract on the activities of superoxide dismutases in physiological repairing of uterus in postpartum rat based on SOD activity, MDA concentration, and Cu, Zn SOD expressions. The experiment was arranged with a factorial, completely randomized design. Seventy-two female rats were divided into 4 groups, namely, control 1 (P01= 9), control 2 (P02= 9), giving birth once (P1= 27), and giving birth twice (P2= 27). The experimental rats were given treatments orally with 4 doses, namely 0 mg/kg BW, 50 mg/kg BW, 100 mg/kg BW, and 150 mg/kg BW. Observation data were taken on days 0, 3, and 5 after parturition. Variables measured were SOD activity, MDA levels, and the number of cells in the uterine tissue expressing Cu, Zn SOD. The results of studies on the condition of P01, P02, P1, and P2 showed significant changes in Cu, Zn SOD expressions. The low of SOD and MDA activities were found at doses of 100 mg and 150 mg. The high number of cells expressing Cu, Zn SOD in the epithelium cells and gland cells were found at a dose of 100 mg. Antioxidant plant extracts and their dosages determine the activities of SOD, MDA, and Cu, Zn SOD expressions in the uterus that will affect the process of repairing and involution of uterine tissue. Allegedly, the bioactive compounds extracted at certain doses effectively affect the physiological repair of cells in the uterine tissue of postpartum mothers.

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  • IPB University
  • Lambung Mangkurat University
  • Indonesian Institute of Sciences
  • Ministry of Agriculture
  • Manado State University
  • National Research and Innovation Agency
  • Indonesian Agency for Agricultural Research and Development
  • Organisasi lain
  • Afiliasi tidak diketahui
  • Organisasi berbeda
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Rekan penulisOrganisasiArtikel bersama
Arief BoedionoIPB University5
Muhammad RizalLambung Mangkurat University4
Rudy PriyantoIPB University4
HERDISAfiliasi tidak diketahui3
Adi WinartoIPB University3
Jakaria JakariaIPB University3
Ronny Rachman NoorIPB University3
Ikhsan SuhendroIPB University3
Yulnawati YulnawatiIndonesian Institute of Sciences2
Nastiti KusumoriniIPB University2
. YulnawatiAfiliasi tidak diketahui2
Krido Brahmo PutroIPB University2
Cece SumantriIPB University2
Huda Shalahudin DarusmanIPB University2
I Wayan Teguh WibawanIPB University1
Etih SudarnikaIPB University1
Maria Fatima PalupiMinistry of Agriculture1
Revolson Alexius MegeManado State University1
Syahrun Hamdani NasutionIPB University1
Muhammad GunawanNational Research and Innovation Agency1
Dedy Duryadi SolihinIPB University1
Sata Yoshida Srie RahayuIPB University1
Ridwan AffandiIPB University1
Ridwan AffandiIPB University1
La EddyIPB University1
Yulvian SaniIndonesian Agency for Agricultural Research and Development1
Irma Herawati SupartoIPB University1
Sela Septima MariyaIPB University1
Uus SaepulohIPB University1
Lis RosmanahIPB University1
Widanarni WidanarniIPB University1
Muhammad ZairinIPB University1
Muhammad Agus SuprayudiIPB University1
Yani HadiroseyaniIPB University1
Benny HeltonikaRiau University1
Agus Oman SudrajatIPB University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.ipb.ac.id/index.php/tasj/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract</dc:title>
	<dc:creator xml:lang="en">Yusfiati</dc:creator>
	<dc:creator xml:lang="en">Manalu, W.</dc:creator>
	<dc:creator xml:lang="en">Maheshwari, H.</dc:creator>
	<dc:creator xml:lang="en">Andryanto</dc:creator>
	<dc:subject xml:lang="en">superoxide dismutase</dc:subject>
	<dc:subject xml:lang="en">repairing activity</dc:subject>
	<dc:subject xml:lang="en">uterus</dc:subject>
	<dc:subject xml:lang="en">tristaniopsis</dc:subject>
	<dc:description xml:lang="en">The study examined the effectiveness of ethyl-acetate fraction of Pelawan extract on the activities of superoxide dismutases in physiological repairing of uterus in postpartum rat based on SOD activity, MDA concentration, and Cu, Zn SOD expressions. The experiment was arranged with a factorial, completely randomized design. Seventy-two female rats were divided into 4 groups, namely, control 1 (P01= 9), control 2 (P02= 9), giving birth once (P1= 27), and giving birth twice (P2= 27). The experimental rats were given treatments orally with 4 doses, namely 0 mg/kg BW, 50 mg/kg BW, 100 mg/kg BW, and 150 mg/kg BW. Observation data were taken on days 0, 3, and 5 after parturition. Variables measured were SOD activity, MDA levels, and the number of cells in the uterine tissue expressing Cu, Zn SOD. The results of studies on the condition of P01, P02, P1, and P2 showed significant changes in Cu, Zn SOD expressions. The low of SOD and MDA activities were found at doses of 100 mg and 150 mg. The high number of cells expressing Cu, Zn SOD in the epithelium cells and gland cells were found at a dose of 100 mg. Antioxidant plant extracts and their dosages determine the activities of SOD, MDA, and Cu, Zn SOD expressions in the uterus that will affect the process of repairing and involution of uterine tissue. Allegedly, the bioactive compounds extracted at certain doses effectively affect the physiological repair of cells in the uterine tissue of postpartum mothers.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Animal Science, IPB University</dc:publisher>
	<dc:date>2021-11-12</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ipb.ac.id/tasj/article/view/33026</dc:identifier>
	<dc:identifier>10.5398/tasj.2021.44.4.415</dc:identifier>
	<dc:source xml:lang="en">Tropical Animal Science Journal; Vol. 44 No. 4 (2021): Tropical Animal Science Journal; 415-424</dc:source>
	<dc:source>2615-790X</dc:source>
	<dc:source>2615-787X</dc:source>
	<dc:source>10.5398/tasj.2021.44.4</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ipb.ac.id/tasj/article/view/33026/22487</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2021 Tropical Animal Science Journal</dc:rights>
</oai_dc:dc>