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The Association of Single Nucleotide Polymorphism -69T>G HSPA1A Gene with Bali Cattle Heat Tolerance

Tropical Animal Science Journal · Vol. 45 No. 4 (2022) · hlm. 429–435

DOI
10.5398/tasj.2022.45.4.429
ISSN
2615-790X, 2615-787X
Terbit
2022-11-28
Penerbit
Faculty of Animal Science, IPB University
Bahasa
eng

Abstrak

Heat shock protein plays an essential role in thermoregulatory during heat stress responses. This study aims to determine the association of single nucleotide polymorphism (SNP) -69T>G in the promoter region of the heat shock protein 70 member 1A (HSPA1A) gene on heat tolerance in Bali cattle. One hundred and sixteen heads of Bali cattle were collected from different locations such as Pangyangan, Bali Island; Serading, Sumbawa Island; and Sembalun, Lombok Island. The SNP was analyzed by genotyping using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), which used BstUI enzyme restriction. Physiological responses including respiration rate (Rr), rectal temperature (Tr), heart rate (Hr), heat tolerance coefficient (HTC), and blood glucose level (Glu) were measured. Association analysis was conducted using a general linear model by setting genotype, altitude, and sex as factors. The SNP -69T>G variant of HSPA1A gene found in this study were wild type (TT) with 144 bp & 498 bp; GG with 144, 236, & 262 bp; and TG with 144, 236, 262, & 498 bp. Bali cattle with the GG genotype had lower (p G HSPA1A was associated with the physiological performances of Bali cattle. SNP -69T>G of HSPA1A could be utilized for candidate marker-assisted selection of Bali cattle to improve the performance of heat tolerance.

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  • IPB University
  • National Research and Innovation Agency
  • Universitas Djuanda
  • Pusat Penelitian dan Pengembangan Peternakan
  • Universitas Halu Oleo
  • Diponegoro University
  • Universitas Indo Global Mandiri
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Rekan penulisOrganisasiArtikel bersama
Cece SumantriIPB University20
Mokhamad Fakhrul UlumIPB University7
Asep GunawanIPB University6
SubandriyoUniversitas Djuanda5
Ismeth InounuIPB University5
Eko HandiwirawanNational Research and Innovation Agency4
Kasita ListyariniIPB University3
Adi WinartoIPB University3
Iman SupriatnaIPB University3
Nastiti KusumoriniIPB University2
Bambang Ngaji UtomoAfiliasi tidak diketahui2
Peni Suprapti HardjosworoIPB University2
E.D GunardiAfiliasi tidak diketahui2
Bess TiesnamurtiPusat Penelitian dan Pengembangan Peternakan2
Arief BoedionoIPB University2
Krido Brahmo PutroIPB University2
Fuadi ZulkipliIPB University2
Edwar EdwarAfiliasi tidak diketahui2
Sutikno SutiknoDiponegoro University2
Henny NurainiIPB University2
Muslimiah MuslimiahIPB University2
Bagus Priyo PurwantoIPB University2
Syahruddin SaidNational Research and Innovation Agency2
Mohamad YaminIPB University2
Harapin HafidUniversitas Halu Oleo1
Karenina Dwi YuliantiIPB University1
Mutasem Ali M. AbuzahraAfiliasi tidak diketahui1
Luki AbdullahIPB University1
Jefirstson Richset RiwukoreUniversitas Indo Global Mandiri1
A. M. FuahIPB University1
Fellyanus HabaoraIPB University1
Yohanes SusantoUniversitas Bina Insan1
Ahmad YaniAfiliasi tidak diketahui1
Revolson Alexius MegeManado State University1
Syahrun Hamdani NasutionIPB University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journal.ipb.ac.id/index.php/tasj/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">The Association of Single Nucleotide Polymorphism -69T&gt;G HSPA1A Gene with Bali Cattle Heat Tolerance</dc:title>
	<dc:creator xml:lang="en">Suhendro, I.</dc:creator>
	<dc:creator xml:lang="en">Jakaria, J.</dc:creator>
	<dc:creator xml:lang="en">Priyanto, R.</dc:creator>
	<dc:creator xml:lang="en">Manalu, W.</dc:creator>
	<dc:creator xml:lang="en">Noor, R. R.</dc:creator>
	<dc:subject xml:lang="en">Bali cattle</dc:subject>
	<dc:subject xml:lang="en">heat tolerance</dc:subject>
	<dc:subject xml:lang="en">HSPA1A gene</dc:subject>
	<dc:subject xml:lang="en">promoter region</dc:subject>
	<dc:subject xml:lang="en">SNP</dc:subject>
	<dc:description xml:lang="en">Heat shock protein plays an essential role in thermoregulatory during heat stress responses. This study aims to determine the association of single nucleotide polymorphism (SNP) -69T&amp;gt;G in the promoter region of the heat shock protein 70 member 1A (HSPA1A) gene on heat tolerance in Bali cattle. One hundred and sixteen heads of Bali cattle were collected from different locations such as Pangyangan, Bali Island; Serading, Sumbawa Island; and Sembalun, Lombok Island. The SNP was analyzed by genotyping using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), which used BstUI enzyme restriction. Physiological responses including respiration rate (Rr), rectal temperature (Tr), heart rate (Hr), heat tolerance coefficient (HTC), and blood glucose level (Glu) were measured. Association analysis was conducted using a general linear model by setting genotype, altitude, and sex as factors. The SNP -69T&amp;gt;G variant of HSPA1A gene found in this study were wild type (TT) with 144 bp &amp;amp; 498 bp; GG with 144, 236, &amp;amp; 262 bp; and TG with 144, 236, 262, &amp;amp; 498 bp. Bali cattle with the GG genotype had lower (p&amp;lt;0.001) Rr and HTC compared to the other genotypes. It could be concluded that physiological performances were lower at high altitudes, and the SNP -69T&amp;gt;G HSPA1A was associated with the physiological performances of Bali cattle. SNP -69T&amp;gt;G of HSPA1A could be utilized for candidate marker-assisted selection of Bali cattle to improve the performance of heat tolerance.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Animal Science, IPB University</dc:publisher>
	<dc:date>2022-11-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ipb.ac.id/tasj/article/view/39990</dc:identifier>
	<dc:identifier>10.5398/tasj.2022.45.4.429</dc:identifier>
	<dc:source xml:lang="en">Tropical Animal Science Journal; Vol. 45 No. 4 (2022): Tropical Animal Science Journal; 429-435</dc:source>
	<dc:source>2615-790X</dc:source>
	<dc:source>2615-787X</dc:source>
	<dc:source>10.5398/tasj.2022.45.4</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ipb.ac.id/tasj/article/view/39990/24456</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2022 Tropical Animal Science Journal</dc:rights>
</oai_dc:dc>