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Typhonium flagelliforme decreases protein expression in murine breast cancer

Universa Medicina · Vol. 33 No. 3 (2014) · hlm. 163–170

DOI
10.18051/UnivMed.2014.v33.163-170
ISSN
2407-2230, 1907-3062
Terbit
2014-12-02
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng

Abstrak

BACKGROUND Breast cancer treatment is still ineffective, having also various side effects. Breast cancer growth is affected by human epidermal growth factor receptor 2 (HER2/neu) and B cell lymphoma 2 (BCL2) expression. In vitro studies on continuous culture of continuous culture of human lymphoblasts (CEMs) showed that Typhonium flagelliforme (TF) increases apoptosis. The objective of this study was to evaluate whether TF syrup (TFS) could decrease HER2/ neu and BCL2 expression as well as breast cancer volume (BCV) in mice. METHODS An experimental post-test only control group design was conducted on 18 C3H mice with breast cancers, randomly allocated to 3 groups of 6. Group 1 received 0.2 ml of distilled water. Group 2 and 3 animals were each given 0.2 ml of 40 mg/ml and 80 mg/ml TFS, respectively. The treatment was given orally once daily for 25 days. Assessment of HER2/neu and BCL2 expression was by immunohistochemistry, whereas BCV was measured by caliper. Anova and LSD were used for data analysis. RESULTS There was a significant difference in HER2/neu and BCL2 expression as well as in BCV among the treatment groups. LSD analysis showed that HER2/neu and BCL2 expression in group 3 (51.60%; 24.60%) was significantly lower than in group 1 (245.40%; 114.40%) as well as group 2 (235.50%; 54.20%) (p=0.000). BCV in group 3 (4392.33 mm3) was significantly greater than BCV in group 1 (253.87 mm3) (p=0.002), but was not significantly different from BCV in group 2 (3667.16 mm3) (p=0.306). CONCLUSION Suplementation with TFS decreases HER2/neu and BCL2 expression. TF appears to be a promising plant demonstarting anti cancer activity.

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22 penulis · 49 tautan kepenulisan bersama · 8 lintas organisasi

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  • Sultan Agung Islamic University
  • Diponegoro University
  • RSUD Prof. Dr. Saiful Anwar Malang
  • Universitas Sumatera Utara
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Rekan penulisOrganisasiArtikel bersama
Hamzah HamzahAfiliasi tidak diketahui1
Thomas Erwin Christian Junus HuwaeRSUD Prof. Dr. Saiful Anwar Malang1
Nur Anna Chalimah Sa'dyahAfiliasi tidak diketahui1
Agung Brastama PutraSultan Agung Islamic University1
Setyo TrisnadiSultan Agung Islamic University1
Hadi SunartoSultan Agung Islamic University1
Arya TjiptaUniversitas Sumatera Utara1
Eko SetiawanSultan Agung Islamic University1
Fanni YuniarSultan Agung Islamic University1
Harvina Dwi AprilianaSultan Agung Islamic University1
Eko SetiawanSultan Agung Islamic University1
Hardhono SusantoDiponegoro University1
Edi DharmanaDiponegoro University1
Sarjadi SarjadiDiponegoro University1
Hadi SarosaSultan Agung Islamic University1
Danis PertiwiSultan Agung Islamic University1
Atina HussaanaSultan Agung Islamic University1
Ulfah Dian IndrayaniSultan Agung Islamic University1
Bagas WidiyantoSultan Agung Islamic University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Typhonium flagelliforme decreases protein expression in murine breast cancer</dc:title>
	<dc:creator xml:lang="en">Chodidjah, Chodidjah</dc:creator>
	<dc:creator xml:lang="en">Nasihun, Taufiqurrahman</dc:creator>
	<dc:creator xml:lang="en">Widayati, Eni</dc:creator>
	<dc:subject xml:lang="en">Breast cancer</dc:subject>
	<dc:subject xml:lang="en">BCL2</dc:subject>
	<dc:subject xml:lang="en">HER2/neu</dc:subject>
	<dc:subject xml:lang="en">apoptosis</dc:subject>
	<dc:subject xml:lang="en">mice</dc:subject>
	<dc:description xml:lang="en">BACKGROUND Breast cancer treatment is still ineffective, having also various side effects. Breast cancer growth is affected by human epidermal growth factor receptor 2 (HER2/neu) and B cell lymphoma 2 (BCL2) expression. In vitro studies on continuous culture of continuous culture of human lymphoblasts (CEMs) showed that Typhonium flagelliforme (TF) increases apoptosis. The objective of this study was to evaluate whether TF syrup (TFS) could decrease HER2/ neu and BCL2 expression as well as breast cancer volume (BCV) in mice. METHODS An experimental post-test only control group design was conducted on 18 C3H mice with breast cancers, randomly allocated to 3 groups of 6. Group 1 received 0.2 ml of distilled water. Group 2 and 3 animals were each given 0.2 ml of 40 mg/ml and 80 mg/ml TFS, respectively. The treatment was given orally once daily for 25 days. Assessment of HER2/neu and BCL2 expression was by immunohistochemistry, whereas BCV was measured by caliper. Anova and LSD were used for data analysis. RESULTS There was a significant difference in HER2/neu and BCL2 expression as well as in BCV among the treatment groups. LSD analysis showed that HER2/neu and BCL2 expression in group 3 (51.60%; 24.60%) was significantly lower than in group 1 (245.40%; 114.40%) as well as group 2 (235.50%; 54.20%) (p=0.000). BCV in group 3 (4392.33 mm3) was significantly greater than BCV in group 1 (253.87 mm3) (p=0.002), but was not significantly different from BCV in group 2 (3667.16 mm3) (p=0.306). CONCLUSION Suplementation with TFS decreases HER2/neu and BCL2 expression. TF appears to be a promising plant demonstarting anti cancer activity.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2014-12-02</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/8</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2014.v33.163-170</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 33 No. 3 (2014); 163-170</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/8/7</dc:relation>
	<dc:relation>10.18051/univmed.v33i3.8</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2014 Chodidjah Chodidjah, Taufiqurrahman Nasihun, Eni Widayati</dc:rights>
</oai_dc:dc>