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Nepenthes rafflesiana pitcher liquid has antifungal activity against Candida spp.

Universa Medicina · Vol. 33 No. 2 (2014) · hlm. 83–90

DOI
10.18051/UnivMed.2014.v33.83-90
ISSN
2407-2230, 1907-3062
Terbit
2014-08-19
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng

Abstrak

BACKGROUNDTo develop new effective antifungals, it is essential to search for antifungal compounds from plants such as Nepenthes spp., which have their greatest diversity in Indonesia. Since chitin-induced liquid (CIL) from Nepenthes khasiana pitchers has antifungal activity, due to their naphthoquinone content, this study aimed to evaluate antifungal activity of Nepenthes rafflesiana pitcher liquids on Candida spp.METHODSCollected pitcher liquids were of 3 types: non-induced liquid (NIL), prey-induced liquid (PIL), and chitin-induced liquid (CIL). Non-induced liquid (NIL) was collected from fresh naturally opened pitchers, PIL from opened pitchers after 3 hours of induction with Zophobas morio larvae, and CIL from closed pitchers after 5 days of chitin solution injection. The antifungal activity of the liquids against C. albicans, C. glabrata, C. krusei, and C. tropicalis were detected by disc diffusion and macrodilution methods.RESULTSInhibition zone diameters of NIL, PIL, and CIL against C. albicans were 35.00 (35.00 – 39.33) mm, 26.33 (23.00 – 40.00) mm, and 30.00 ( 28.00 – 32.00) mm, respectively, while for C. glabrata the zone diameters were 22.22 ± 3.66 mm, 29.89 ± 2.79 mm, and 28.89 ± 1.17 mm, respectively. No inhibition zones were found for NIL, PIL, and CIL against C. krusei and C. tropicalis. At concentrations of 80%, almost all samples showed visually apparent inhibition of fungal growth.CONCLUSIONThe pitcher liquid of N. rafflesiana has antifungal properties, presumably due to the presence of many potentially active substances, such as naphthoquinones, as has been proven in other studies.

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  • Atma Jaya Catholic University of Indonesia
  • University of Indonesia
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Rekan penulisOrganisasiArtikel bersama
Maria Dara Novi HandayaniAtma Jaya Catholic University of Indonesia1
Hotmaria Agustina PakpahanAfiliasi tidak diketahui1
Ferbian Milas SiswantoAtma Jaya Catholic University of Indonesia1
Ian PranandiAfiliasi tidak diketahui1
William WilliamAfiliasi tidak diketahui1
Evi Ulina Margaretha SitumorangAfiliasi tidak diketahui1
Jojor Lamsihar ManaluUniversity of Indonesia1
Ana Lucia EkowatiAfiliasi tidak diketahui1
Yulia Tanti NarwatiAfiliasi tidak diketahui1
Lies K. WibisonoAfiliasi tidak diketahui1
Jenny HidayatAtma Jaya Catholic University of Indonesia1
Ay Ly MargaretAtma Jaya Catholic University of Indonesia1
Ayly MargaretAtma Jaya Catholic University of Indonesia1
Lies K. WibisonoAtma Jaya Catholic University of Indonesia1
Meiliyana WijayaAtma Jaya Catholic University of Indonesia1
Sem Samuel SurjaAtma Jaya Catholic University of Indonesia1
Melyawati HermawanAtma Jaya Catholic University of Indonesia1
Pramanta PramantaAtma Jaya Catholic University of Indonesia1

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Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Nepenthes rafflesiana pitcher liquid has antifungal activity against Candida spp.</dc:title>
	<dc:creator xml:lang="en">Yolanda, Hanna</dc:creator>
	<dc:creator xml:lang="en">Makahinda, Ingrid M.</dc:creator>
	<dc:creator xml:lang="en">Aprilia, Maureen</dc:creator>
	<dc:creator xml:lang="en">Sanjaya, Nikki</dc:creator>
	<dc:creator xml:lang="en">Gunawan, Harry</dc:creator>
	<dc:creator xml:lang="en">Dewi, Rita</dc:creator>
	<dc:subject xml:lang="en">Antifungal</dc:subject>
	<dc:subject xml:lang="en">chitin-induced</dc:subject>
	<dc:subject xml:lang="en">disc diffusion</dc:subject>
	<dc:subject xml:lang="en">Nepenthes</dc:subject>
	<dc:subject xml:lang="en">Candida</dc:subject>
	<dc:description xml:lang="en">BACKGROUNDTo develop new effective antifungals, it is essential to search for antifungal compounds from plants such as Nepenthes spp., which have their greatest diversity in Indonesia. Since chitin-induced liquid (CIL) from Nepenthes khasiana pitchers has antifungal activity, due to their naphthoquinone content, this study aimed to evaluate antifungal activity of Nepenthes rafflesiana pitcher liquids on Candida spp.METHODSCollected pitcher liquids were of 3 types: non-induced liquid (NIL), prey-induced liquid (PIL), and chitin-induced liquid (CIL). Non-induced liquid (NIL) was collected from fresh naturally opened pitchers, PIL from opened pitchers after 3 hours of induction with Zophobas morio larvae, and CIL from closed pitchers after 5 days of chitin solution injection. The antifungal activity of the liquids against C. albicans, C. glabrata, C. krusei, and C. tropicalis were detected by disc diffusion and macrodilution methods.RESULTSInhibition zone diameters of NIL, PIL, and CIL against C. albicans were 35.00 (35.00 – 39.33) mm, 26.33 (23.00 – 40.00) mm, and 30.00 ( 28.00 – 32.00) mm, respectively, while for C. glabrata the zone diameters were 22.22 ± 3.66 mm, 29.89 ± 2.79 mm, and 28.89 ± 1.17 mm, respectively. No inhibition zones were found for NIL, PIL, and CIL against C. krusei and C. tropicalis. At concentrations of 80%, almost all samples showed visually apparent inhibition of fungal growth.CONCLUSIONThe pitcher liquid of N. rafflesiana has antifungal properties, presumably due to the presence of many potentially active substances, such as naphthoquinones, as has been proven in other studies.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2014-08-19</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/11</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2014.v33.83-90</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 33 No. 2 (2014); 83-90</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/11/8</dc:relation>
	<dc:relation>10.18051/univmed.v33i2.11</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2014 Hanna Yolanda, Ingrid M. Makahinda, Maureen Aprilia, Nikki Sanjaya, Harry Gunawan, Rita Dewi</dc:rights>
</oai_dc:dc>