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Red fruit oil supplementation fails to prevent oxidative stress in rats

Universa Medicina · Vol. 32 No. 2 (2013) · hlm. 86–91

DOI
10.18051/UnivMed.2013.v32.86-91
ISSN
2407-2230, 1907-3062
Terbit
2013-08-14
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng

Abstrak

BACKGROUNDRed fruit oil (RFO) is popular in Indonesia especially in Papua. It is consumed by people for maintaining health and to treat diseases. Red fruit (Pandanus conoideus Lam) oil is reported to contain the antioxidants á-tocoferol and âcarotene.The aim of this study was to confirm the protective effect of RFOagainst decreased glutathione levels in the plasma and liver of rats induced by 2N-(2-fluorenyl) acetamide (2-FAA).METHODSWistar male rats weighing 200 ± 20 g were randomly assigned into a control group (receiving distilled water only) and three intervention groups, designated RFO, FAA, and RFO-FAA (n=6 rats per group). RFO was given RFO 10 ì l/g/BW/day, FAA received fluoroenylacetamide (FAA) at 40ìg/day, while RFOFAA received both RFO and FAA. At 4 weeks blood samples were taken from the tail. At 8 weeks the rats were sacrified for collection of blood and liver tissues. Ellman’s method was employed to determine the parameters of antioxidantglutathione (glutahione sulfhydryl/GSH). One-way ANOVA and Tukey post hoc test were used to compare glutathione levels between groups.RESULTSThis study showed that liver and plasma glutathione levels were not significantly lower in the RFO-FAA group than in the FAA group. Glutathione levels were significantly lower in plasma and liver homogenates of the RFO group compared with the control group and were not significantly different from those in theFAA group.CONCLUSIONAdministration of RFO in rats does not protect against decreased glutathione but is a potential source of oxidative stress.

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Mohamad SadikinAfiliasi tidak diketahui3
RINI PUSPITANINGRUMAfiliasi tidak diketahui3
RONDANG ROEMIATI SOEGIANTOAfiliasi tidak diketahui3
Hotmaria Agustina PakpahanAfiliasi tidak diketahui1
Ferbian Milas SiswantoAfiliasi tidak diketahui1
Rita DewiAfiliasi tidak diketahui1
Ian PranandiAfiliasi tidak diketahui1
William WilliamAfiliasi tidak diketahui1
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DARYL ROBERT WILLIAMSAfiliasi tidak diketahui1
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Sri HandayaniUniversity of Brawijaya1
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Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Red fruit oil supplementation fails to prevent oxidative stress in rats</dc:title>
	<dc:creator xml:lang="en">Handayani, Maria Dara Novi</dc:creator>
	<dc:creator xml:lang="en">Soekarno, Parwati Abadi</dc:creator>
	<dc:creator xml:lang="en">Wanandi, Septelia Inawati</dc:creator>
	<dc:subject xml:lang="en">Red fruit oil</dc:subject>
	<dc:subject xml:lang="en">oxidative stress</dc:subject>
	<dc:subject xml:lang="en">N-(2-Fluoroenyl) acetamide</dc:subject>
	<dc:subject xml:lang="en">glutathione</dc:subject>
	<dc:subject xml:lang="en">rats</dc:subject>
	<dc:description xml:lang="en">BACKGROUNDRed fruit oil (RFO) is popular in Indonesia especially in Papua. It is consumed by people for maintaining health and to treat diseases. Red fruit (Pandanus conoideus Lam) oil is reported to contain the antioxidants á-tocoferol and âcarotene.The aim of this study was to confirm the protective effect of RFOagainst decreased glutathione levels in the plasma and liver of rats induced by 2N-(2-fluorenyl) acetamide (2-FAA).METHODSWistar male rats weighing 200 ± 20 g were randomly assigned into a control group (receiving distilled water only) and three intervention groups, designated RFO, FAA, and RFO-FAA (n=6 rats per group). RFO was given RFO 10 ì l/g/BW/day, FAA received fluoroenylacetamide (FAA) at 40ìg/day, while RFOFAA received both RFO and FAA. At 4 weeks blood samples were taken from the tail. At 8 weeks the rats were sacrified for collection of blood and liver tissues. Ellman’s method was employed to determine the parameters of antioxidantglutathione (glutahione sulfhydryl/GSH). One-way ANOVA and Tukey post hoc test were used to compare glutathione levels between groups.RESULTSThis study showed that liver and plasma glutathione levels were not significantly lower in the RFO-FAA group than in the FAA group. Glutathione levels were significantly lower in plasma and liver homogenates of the RFO group compared with the control group and were not significantly different from those in theFAA group.CONCLUSIONAdministration of RFO in rats does not protect against decreased glutathione but is a potential source of oxidative stress.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2013-08-14</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/65</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2013.v32.86-91</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 32 No. 2 (2013); 86-91</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/65/79</dc:relation>
	<dc:relation>10.18051/univmed.v32i2.65</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2015 Maria Dara Novi Handayani, Parwati Abadi Soekarno, Septelia Inawati Wanandi</dc:rights>
</oai_dc:dc>