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Nicotine supplementation blocks oocyte maturation in Rattus norvegicus

Universa Medicina · Vol. 32 No. 2 (2013) · hlm. 92–98

DOI
10.18051/UnivMed.2013.v32.92-98
ISSN
2407-2230, 1907-3062
Terbit
2013-08-14
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng

Abstrak

BACKGROUNDIndonesia has the third largest tobacco consumption in the world after China and India. Nicotine as the main component of cigarette smoke has negative effects on the reproductive system, such as oocyte maturation, ovulation, and fertilization, and increasing the diploidy of oocytes. The goal of this researchwas to evaluate the effect of nicotine on oocyte maturation in Rattus norvegicus.METHODSThis was an experimental study with post test only control group design. The subjects were 40 rats selected homogenously and randomly. They were divided into a control group (receiving carboxy-methyl-cellulose sodium and 3 treatment groups (I-III) receiving nicotine subcutaneously for 7 days at dosages of 21 mg/ kgBW, 41 kg/kgBW and 84/kgBW, respectively. The observations comprised oocyte maturation stage, viz. germinal vesicle (GV), germinal vesicle breakdown (GVBD), metaphase I and metaphase II. Data were analyzed by one-way Anova with á=0.05, followed by Tukey’s HSD test.RESULTSOne-way Anova showed significant differences in oocyte maturation in all groups. Tukey’s HSD test showed that for GV, the differing groups were control and I, control and II, I and III. For GVBD, the differing groups were control and I, I andII, I and III. For metaphase I, the differing groups were control with I, II, and III, I and II, I and III. For metaphase II, the differing groups were control versus I, II, and III, I and II, I and III.CONCLUSIONLow dose of nicotine is capable of affecting oocyte maturation in Rattus norvegicus.

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  • Lambung Mangkurat University
  • Diponegoro University
  • Universitas Airlangga
  • Universitas Esa Unggul
  • IPB University
  • University of Mataram
  • University of Indonesia
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Rekan penulisOrganisasiArtikel bersama
Rosihan AdhaniLambung Mangkurat University3
Muhammad Abdan ShadiqiLambung Mangkurat University3
Hardinsyah HardinsyahIPB University2
Dodik BriawanIPB University2
Erry Yudhya MulyaniUniversitas Esa Unggul2
Fauzie RahmanLambung Mangkurat University2
Syamsul ArifinLambung Mangkurat University2
Husaini HusainiLambung Mangkurat University2
Neka ErlyaniLambung Mangkurat University2
Muhamad MuslimAfiliasi tidak diketahui2
Syarief Thaufik HidayatDiponegoro University2
Erma SafitriUniversitas Airlangga2
Esti YunitasariUniversitas Airlangga2
Ifa HafifahLambung Mangkurat University1
Ha Thi Thu TrangVNU University of Medicine and Pharmacy1
Ayu Riana Sari AzwariLambung Mangkurat University1
Adi NugrohoLambung Mangkurat University1
A. Heri IswantoUniversitas Pembangunan Nasional Veteran Jakarta1
Herawati HerawatiLambung Mangkurat University1
M. RamadhanAfiliasi tidak diketahui1
Romi ErmawanUniversity of Mataram1
Yudi Her OktavionoUniversitas Airlangga1
Budi Susetyo PikirUniversitas Airlangga1
Mulyanto MulyantoUniversity of Mataram1
Budi UtomoUniversitas Airlangga1
Idrus Jus’atUniversitas Esa Unggul1
Seindy GlamourDiponegoro University1
Adi Setyawan PriantoDiponegoro University1
Inu MulyantoroDiponegoro University1
Oktoria IndraprajaDiponegoro University1
Noor Pramono NoerpramanaDiponegoro University1
Noor PramonoDiponegoro University1
Yuli TrisetiyonoDiponegoro University1
Wiwin WiarsihUniversity of Indonesia1
Junaiti SaharUniversity of Indonesia1
Carolina ArdyAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Nicotine supplementation blocks oocyte maturation in Rattus norvegicus</dc:title>
	<dc:creator xml:lang="en">Noor, Meitria Syahadatina</dc:creator>
	<dc:creator xml:lang="en">Bahkriansyah, H.M</dc:creator>
	<dc:creator xml:lang="en">Widjiati, Widjiati</dc:creator>
	<dc:creator xml:lang="en">Santoso, Budi</dc:creator>
	<dc:subject xml:lang="en">Nicotine</dc:subject>
	<dc:subject xml:lang="en">maturation</dc:subject>
	<dc:subject xml:lang="en">oocyte</dc:subject>
	<dc:subject xml:lang="en">Rattus norvegicus</dc:subject>
	<dc:description xml:lang="en">BACKGROUNDIndonesia has the third largest tobacco consumption in the world after China and India. Nicotine as the main component of cigarette smoke has negative effects on the reproductive system, such as oocyte maturation, ovulation, and fertilization, and increasing the diploidy of oocytes. The goal of this researchwas to evaluate the effect of nicotine on oocyte maturation in Rattus norvegicus.METHODSThis was an experimental study with post test only control group design. The subjects were 40 rats selected homogenously and randomly. They were divided into a control group (receiving carboxy-methyl-cellulose sodium and 3 treatment groups (I-III) receiving nicotine subcutaneously for 7 days at dosages of 21 mg/ kgBW, 41 kg/kgBW and 84/kgBW, respectively. The observations comprised oocyte maturation stage, viz. germinal vesicle (GV), germinal vesicle breakdown (GVBD), metaphase I and metaphase II. Data were analyzed by one-way Anova with á=0.05, followed by Tukey’s HSD test.RESULTSOne-way Anova showed significant differences in oocyte  maturation in all groups. Tukey’s HSD test showed that for GV, the differing groups were control and I, control and II, I and III. For GVBD, the differing groups were control and I, I andII, I and III. For metaphase I, the differing groups were control with I, II, and III, I and II, I and III. For metaphase II, the differing groups were control versus I, II, and III, I and II, I and III.CONCLUSIONLow dose of nicotine is capable of affecting oocyte maturation in Rattus norvegicus.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2013-08-14</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/68</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2013.v32.92-98</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 32 No. 2 (2013); 92-98</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/68/82</dc:relation>
	<dc:relation>10.18051/univmed.v32i2.68</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2015 Meitria Syahadatina Noor, H.M Bahkriansyah, Widjiati Widjiati, Budi Santoso</dc:rights>
</oai_dc:dc>