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Typhonium flagelliforme decreases tyrosine kinase and Ki67 expression in mice

Universa Medicina · Vol. 32 No. 3 (2013) · hlm. 146–154

DOI
10.18051/UnivMed.2013.v32.146-154
ISSN
2407-2230, 1907-3062
Terbit
2013-12-07
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng

Abstrak

Background Worldwide, breast cancer is the most frequent cancer in women after lung cancer. Treatments include surgery, radiation, immunotherapy and chemotherapy, but are not effective. Tyrosine kinase and Ki67 protein are markers of proliferation. Typhonium flagelliforme ethanol extract (TFEE) has been shown to inhibit proliferation of Michigan Cancer Foundation-7 (MCF7) cells in culture. The aim of the present study was to examine the effect of administration of TFEE on tyrosine kinase and Ki67 expression in mice. Methods This experimental study using post test randomized design with control group was conducted in 24 tumor-bearing CH3 mice. They were randomly divided into 4 groups, consisting of one control and 3 treatment groups (TI, T2, T3) treated daily for 30 days with 0.2 ml TFEE at dosages of 200, 400, and 800 mg/kgBW, respectively. On day 31 the tumor tissues were collected and their tyrosine kinase and Ki67 expression were levels assessed using ELISA and immunohistochemical staining, respectively. Tyrosine kinase and Ki67 expression levels were analyzed, respectively using Kruskal Wallis test and one-way Anova followed by Bonferroni post hoc test. Results Mean tyrosine kinase level was highest in the control group, followed by T3, T2 and T1 (p=0.019). Mean level of Ki 67 expression was highest in the control group, followed by T2, T3 and T1 (p=0.000). Conclussions Oral administration of TFEE at a dose of 200 mg/kgBW decreases tyrosine kinase levels and Ki 67 expression.

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  • Diponegoro University
  • Sultan Agung Islamic University
  • Eijkman Institute for Molecular Biology
  • Satya Wacana Christian University
  • Siliwangi University
  • Universitas Jambi
  • RSUD Prof. Dr. Saiful Anwar Malang
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Miftahul AdnanDiponegoro University1
Diana Nur AfifahDiponegoro University1
Gemala AnjaniDiponegoro University1
Etika Ratna NoerDiponegoro University1
Sumardi WidodoDiponegoro University1
Suharyo HadisaputroDiponegoro University1
Ai Sri KosnayaniSiliwangi University1
Ignatius RiwantoDiponegoro University1
Rebriarina HapsariDiponegoro University1
Jonathan Alvin Nugraha HalimDiponegoro University1
Stefanie Natalia HalimDiponegoro University1
Dionisius DenisEijkman Institute for Molecular Biology1
Sotianingsih HaryantoUniversitas Jambi1
R. Tedjo SasmonoEijkman Institute for Molecular Biology1
Benediktus YohanEijkman Institute for Molecular Biology1
Hamzah HamzahAfiliasi tidak diketahui1
Thomas Erwin Christian Junus HuwaeRSUD Prof. Dr. Saiful Anwar Malang1
Nur Anna Chalimah Sa'dyahAfiliasi tidak diketahui1
Agung Brastama PutraSultan Agung Islamic University1
Setyo TrisnadiSultan Agung Islamic University1
Hadi SunartoSultan Agung Islamic University1
Arya TjiptaUniversitas Sumatera Utara1
Eko SetiawanSultan Agung Islamic University1
Fanni YuniarSultan Agung Islamic University1
Suhartono SuhartonoDiponegoro University1
Sultana MH FaradzDiponegoro University1
Noor PramonoDiponegoro University1
Banundari RachmawatiDiponegoro University1
Mochammad Besari Adi PramonoDiponegoro University1
Harvina Dwi AprilianaSultan Agung Islamic University1
Eko SetiawanSultan Agung Islamic University1
Maria Dyah KurniasariSatya Wacana Christian University1
Hussein GasemSatya Wacana Christian University1
Taufiqurrahman NasihunSultan Agung Islamic University1
Eni WidayatiSultan Agung Islamic University1
Nugrahaningsih NugrahaningsihState University of Semarang1

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Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Typhonium flagelliforme decreases tyrosine kinase  and Ki67 expression in mice</dc:title>
	<dc:creator xml:lang="en">Chodidjah, Chodidjah</dc:creator>
	<dc:creator xml:lang="en">Dharmana, Edi</dc:creator>
	<dc:creator xml:lang="en">Susanto, Hardhono</dc:creator>
	<dc:creator xml:lang="en">Sarjadi, Sarjadi</dc:creator>
	<dc:subject xml:lang="en">Typhonium flagelliforme</dc:subject>
	<dc:subject xml:lang="en">tyrosine kinase</dc:subject>
	<dc:subject xml:lang="en">Ki67 expression</dc:subject>
	<dc:subject xml:lang="en">mammary adenocarcinoma</dc:subject>
	<dc:subject xml:lang="en">mice</dc:subject>
	<dc:description xml:lang="en">Background Worldwide, breast cancer is the most frequent cancer in women after lung cancer. Treatments include surgery, radiation, immunotherapy and chemotherapy, but are not effective. Tyrosine kinase and Ki67 protein are markers of proliferation. Typhonium flagelliforme ethanol extract (TFEE) has been shown to inhibit proliferation of Michigan Cancer Foundation-7 (MCF7) cells in culture. The aim of the present study was to examine the effect of administration of TFEE on tyrosine kinase and Ki67 expression in mice. Methods This experimental study using post test randomized design with control group was conducted in 24 tumor-bearing CH3 mice. They were randomly divided into 4 groups, consisting of one control and 3 treatment groups (TI, T2, T3) treated daily for 30 days with 0.2 ml TFEE at dosages of 200, 400, and 800 mg/kgBW, respectively. On day 31 the tumor tissues were collected and their tyrosine kinase and Ki67 expression were levels assessed using ELISA and immunohistochemical staining, respectively. Tyrosine kinase and Ki67 expression levels were analyzed, respectively using Kruskal Wallis test and one-way Anova followed by Bonferroni post hoc test. Results Mean tyrosine kinase level was highest in the control group, followed by T3, T2 and T1 (p=0.019). Mean level of Ki 67 expression was highest in the control group, followed by T2, T3 and T1 (p=0.000). Conclussions Oral administration of TFEE at a dose of 200 mg/kgBW decreases tyrosine kinase levels and Ki 67 expression.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2013-12-07</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/88</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2013.v32.146-154</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 32 No. 3 (2013); 146-154</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/88/99</dc:relation>
	<dc:relation>10.18051/univmed.v32i3.88</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2015 Chodidjah Chodidjah, Edi Dharmana, Hardhono Susanto, Sarjadi Sarjadi</dc:rights>
</oai_dc:dc>