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Bone microstructure and atomic periodic disharmonization in osteoporosis

Universa Medicina · Vol. 31 No. 2 (2012) · hlm. 96–104

DOI
10.18051/UnivMed.2012.v31.96-104
ISSN
2407-2230, 1907-3062
Terbit
2012-08-14
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng

Abstrak

BackgroundBoth cortical and cancellous bone display a complex, porous microstructure whose properties depend on the macrostructure of bone as well as age and health of the individual. The aim of this study was to compare the microstructure and characteristics of mineral atoms in osteoporotic and normal bone. MethodsA prospective laboratory experimental study was conducted from August to December 2010 at several hospitals in Banjarmasin. Twenty patients with osteoporosis and twenty six normal patients were involved in this study. Bone obtained from surgery was analyzed for microstructure by scanning electron microscopy (SEM), while mapping of mineral atoms was performed by means of SEM-Energy dispersive X-ray spectroscopy (SEM-EDAX) at the Brawijaya University, Malang. ResultsThe osteoporotic subjects with mean age of 64.65 ± 16.41 years were older than the normal bone subjects with mean age of 39.38 ± 17.16 years. The body mass index was similar in both groups of subjects. From SEM-EDAX results, three patterns of mineral atoms were apparent in osteoporotic and normal bone. In osteoporotic bone, these patterns were indicative of a disordered substitution or incorporation process. SEM results showed degeneration of microarchitecture (resorption cavities, perforations, and prominent granules) in osteoporotic but not in normal bone. There was a significant difference in microstructure between osteoporotic and normal bone, which was caused by differences in atomic properties. ConclusionsMicrostructural abnormalities of bone and disharmonization of mineral atoms in the periodic system were found in osteoporosis.

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  • University of Brawijaya
  • Lambung Mangkurat University
  • Maranatha Christian University
  • Diponegoro University
  • Dr. Hasan Sadikin General Hospital
  • IPB University
  • Universitas Airlangga
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Rekan penulisOrganisasiArtikel bersama
A Aulanni’amUniversity of Brawijaya2
. WIDJIATIAfiliasi tidak diketahui1
Arief BoedionoIPB University1
Aucky HintingUniversitas Airlangga1
Trinil SusilowatiUniversity of Brawijaya1
Luchman HakimUniversity of Brawijaya1
Abdul Hamid A. TohaUniversitas Papua1
Widodo WidodoState University of Jakarta1
Ambariyanto AmbariyantoDiponegoro University1
Agustina L. N. AmininDiponegoro University1
Ratna SetyaningrumLambung Mangkurat University1
Husda OktaviannoorLambung Mangkurat University1
Sri Rahayu LestariState University of Malang1
Dina MaulinaLampung University1
Dominikus Djago DjoaUniversitas Flores1
Dwi Davidson RihibihaAfiliasi tidak diketahui1
Annisa AmaliaBandung Institute of Technology1
Wahyu WidowatiMaranatha Christian University1
Ervi AfifahAfiliasi tidak diketahui1
Rizal RizalUniversity of Indonesia1
Diana Krisanti JasaputraMaranatha Christian University1
Hanna Sari Widya KusumaAfiliasi tidak diketahui1
Philips OnggowidjajaMaranatha Christian University1
Harry MurtiAfiliasi tidak diketahui1
Indra BachtiarAfiliasi tidak diketahui1
Mochammad Aris WidodoUniversity of Brawijaya1
Gatot CiptadiUniversity of Brawijaya1
Nurul Jadid MubarakatiUniversitas Islam Malang1
Aulanni’am Aulanni’amUniversity of Brawijaya1
Hidayat SujutiUniversity of Brawijaya1
Yuda Heru FibriantoUniversitas Gadjah Mada1
Bintang SoetjahjoUniversity of Brawijaya1
Simon Bambang WidjanarkoUniversity of Brawijaya1
Dionysius Joseph Djoko Herry SantjojoUniversity of Brawijaya1
Hostalige HutasoitUniversity of Brawijaya1
Natasya Adiba ZahrahUniversity of Brawijaya1

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Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc)
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	<dc:title xml:lang="en">Bone microstructure and atomic periodic disharmonization in osteoporosis</dc:title>
	<dc:creator xml:lang="en">Noor, Zairin</dc:creator>
	<dc:creator xml:lang="en">Hidayat, Mohammad</dc:creator>
	<dc:creator xml:lang="en">Rahim, Agus Hadian</dc:creator>
	<dc:creator xml:lang="en">Sumitro, Sutiman B.</dc:creator>
	<dc:subject xml:lang="en">Mineral atoms</dc:subject>
	<dc:subject xml:lang="en">composite</dc:subject>
	<dc:subject xml:lang="en">microstructure</dc:subject>
	<dc:subject xml:lang="en">osteoporosis</dc:subject>
	<dc:description xml:lang="en">BackgroundBoth cortical and cancellous bone display a complex, porous microstructure whose properties depend on the macrostructure of bone as well as age and health of the individual. The aim of this study was to compare the microstructure and characteristics of mineral atoms in osteoporotic and normal bone. MethodsA prospective laboratory experimental study was conducted from August to December 2010 at several hospitals in Banjarmasin. Twenty patients with osteoporosis and twenty six normal patients were involved in this study. Bone obtained from surgery was analyzed for microstructure by scanning electron microscopy (SEM), while mapping of mineral atoms was performed by means of SEM-Energy dispersive X-ray spectroscopy (SEM-EDAX) at the Brawijaya University, Malang.     ResultsThe osteoporotic subjects with mean age of 64.65 ± 16.41 years were older than the normal bone subjects with mean age of 39.38 ± 17.16 years. The body mass index was similar in both groups of subjects. From SEM-EDAX results, three patterns of mineral atoms were apparent in osteoporotic and normal bone. In osteoporotic bone, these patterns were indicative of a disordered substitution or incorporation process. SEM results showed degeneration of microarchitecture (resorption cavities, perforations, and prominent granules) in osteoporotic but not in normal bone. There was a significant difference in microstructure between osteoporotic and normal bone, which was caused by differences in atomic properties.    ConclusionsMicrostructural abnormalities of bone and disharmonization of mineral atoms in the periodic system were found in osteoporosis.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2012-08-14</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/101</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2012.v31.96-104</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 31 No. 2 (2012); 96-104</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/101/112</dc:relation>
	<dc:relation>10.18051/univmed.v31i2.101</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2015 Zairin Noor, Mohammad Hidayat, Agus Hadian Rahim, Sutiman B. Sumitro</dc:rights>
</oai_dc:dc>