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Assessment of microarchitecture and crystal structure of hydroxyapatite in osteoporosis

Universa Medicina · Vol. 30 No. 1 (2011) · hlm. 29–35

DOI
10.18051/UnivMed.2011.v30.29-35
ISSN
2407-2230, 1907-3062
Terbit
2011-04-23
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng

Abstrak

Osteoporosis is characterized by lower bone mineral density (BMD) and microarchitectural degeneration, which tends to increase bone fragility and fracture risk. Bone microstructure depends on interactions between the mineral atoms, which may perform substitution or incorporation into bone crystals, and may dynamically take over the function of calcium or may become a complementary part. The mineral atoms may also become a composite in the hydroxyapatite crystals. The aim of this study was to find an association between the bone microstructure and hydoxyapatite crystal structure in osteoporosis, in comparison to normal bone. The subjects of this study were surgery patients at the Department of Orthopedics of Ulin General Hospital in Banjarmasin and other centers. Inclusion criteria consisted of the presence of fracture of trabecular bone, normal or osteoporotic BMD values, and no past history of chronic disease. Bone was obtained from fracture patients during surgery. The characteristics of the hydroxyapatite crystals were analyzed by X-ray diffraction (XRD) and the microarchitecture by scanning electron microscopy (SEM). SEM showed degeneration of the microarchitecture of osteoporotic bone, in comparison with normal bone. On XRD there was a peak of hydoxyapatite crystals only and no other crystal phases. Diffraction patterns showed a larger crystal size in osteoporotic bone as compared to normal bone, indicating higher porosity. It may be concluded that there is a difference in crystal size and morphologic distribution of hydoxyapatite in osteoporotic bone, determining bone microarchitecture.

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  • University of Brawijaya
  • State University of Malang
  • Lambung Mangkurat University
  • Universitas Islam Negeri Maulana Malik Ibrahim
  • Institut Teknologi Sepuluh Nopember
  • Diponegoro University
  • Dr. Hasan Sadikin General Hospital
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Rekan penulisOrganisasiArtikel bersama
A Aulanni’amUniversity of Brawijaya2
Wildana WargadinataUniversitas Islam Negeri Maulana Malik Ibrahim1
Abdul RohmanUniversitas Islam Negeri Maulana Malik Ibrahim1
Ali MaksumUniversity of Brawijaya1
Sunaryono SunaryonoState University of Malang1
Edy Giri Rachman PutraNational Nuclear Energy Agency of Indonesia1
Nurul HidayatState University of Malang1
Atsushi OkazawaThe University of Tokyo1
Isao WatanabeRIKEN1
Nobuhiko KojimaToyota Physical and Chemical Research Institute1
Suminar PratapaInstitut Teknologi Sepuluh Nopember1
Darminto DarmintoInstitut Teknologi Sepuluh Nopember1
. WIDJIATIAfiliasi tidak diketahui1
Arief BoedionoIPB University1
Aucky HintingUniversitas Airlangga1
Trinil SusilowatiUniversity of Brawijaya1
Luchman HakimUniversity of Brawijaya1
Abdul Hamid A. TohaUniversitas Papua1
Widodo WidodoState University of Jakarta1
Ambariyanto AmbariyantoDiponegoro University1
Agustina L. N. AmininDiponegoro University1
Hendra SusantoState University of Malang1
Moch SholehUniversity of Brawijaya1
Agustina Tri EndhartiUniversity of Brawijaya1
Nik Ahmad Nizam Nik MalekUniversity of Technology Malaysia1
Sa’diyatul Rizqie Amaliyah FirdausUniversity of Brawijaya1
Adeodatus Yuda HandayaRumah Sakit Umum Pusat Dr. Sardjito1
Markus DiantoroState University of Malang1
Lisa Ainun NajihahState University of Malang1
Abdulloh FuadState University of Malang1
Arif HidayatState University of Malang1
S SubaktiState University of Malang1
Ratna SetyaningrumLambung Mangkurat University1
Husda OktaviannoorLambung Mangkurat University1
Dina MaulinaLampung University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc)
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	<dc:title xml:lang="en">Assessment of microarchitecture and crystal structure of hydroxyapatite in osteoporosis</dc:title>
	<dc:creator xml:lang="en">Noor, Zairin</dc:creator>
	<dc:creator xml:lang="en">Sumitro, Sutiman B</dc:creator>
	<dc:creator xml:lang="en">Hidayat, Mohammad</dc:creator>
	<dc:creator xml:lang="en">Rahim, Agus Hadian</dc:creator>
	<dc:creator xml:lang="en">Taufiq, Ahmad</dc:creator>
	<dc:subject xml:lang="en">Microarchitecture</dc:subject>
	<dc:subject xml:lang="en">hydroxyapatite</dc:subject>
	<dc:subject xml:lang="en">osteoporosis</dc:subject>
	<dc:description xml:lang="en">Osteoporosis is characterized by lower bone mineral density (BMD) and microarchitectural degeneration, which tends to increase bone fragility and fracture risk. Bone microstructure depends on interactions between the mineral atoms, which may perform substitution or incorporation into bone crystals, and may dynamically take over the function of calcium or may become a complementary part. The mineral atoms may also become a composite in the hydroxyapatite crystals. The aim of this study was to find an association between the bone microstructure and hydoxyapatite crystal structure in osteoporosis, in comparison to normal bone. The subjects of this study were surgery patients at the Department of Orthopedics of Ulin General Hospital in Banjarmasin and other centers. Inclusion criteria consisted of the presence of fracture of trabecular bone, normal or osteoporotic BMD values, and no past history of chronic disease. Bone was obtained from fracture patients during surgery. The characteristics of the hydroxyapatite crystals were analyzed by X-ray diffraction (XRD) and the microarchitecture by scanning electron microscopy (SEM). SEM showed degeneration of the microarchitecture of osteoporotic bone, in comparison with normal bone. On XRD there was a peak of hydoxyapatite crystals only and no other crystal phases. Diffraction patterns showed a larger crystal size in osteoporotic bone as compared to normal bone, indicating higher porosity. It may be concluded that there is a difference in crystal size and morphologic distribution of hydoxyapatite in osteoporotic bone, determining bone microarchitecture.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2011-04-23</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/188</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2011.v30.29-35</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 30 No. 1 (2011); 29-35</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/188/159</dc:relation>
	<dc:relation>10.18051/univmed.v30i1.188</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2016 Zairin Noor, Sutiman B Sumitro, Mohammad Hidayat, Agus Hadian Rahim, Ahmad Taufiq</dc:rights>
</oai_dc:dc>