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Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections

Universa Medicina · Vol. 35 No. 3 (2016) · hlm. 206–212

DOI
10.18051/UnivMed.2016.v35.206-212
ISSN
2407-2230, 1907-3062
Terbit
2016-12-06
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng

Abstrak

BackgroundSoil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute the effect of STH treatment on serum zinc concentration in elementary school children in Jakarta. MethodsA pre-experimental study (one group pre and post) was conducted on 3rd - 5th grade students in one elementary school in North Jakarta. FLOTAC examination was used to determine infection status and STH intensity, while serum zinc concentrations were measured by atomic absorption spectrometry. All children were given albendazole 400 mg for three consecutive days. Stool and blood samples were collected before and three weeks after treatment with albendazole. A paired t test was used to analyze the data. ResultsThe STH prevalence was 63.4%; these were mainly Ascaris lumbricoides and Trichuris trichiura infections. Before treatment, children infected with A.lumbricoides and T.trichiura had significantly higher serum zinc concentrations (p=0.028; p=0.014). After treatment, children with A.lumbricoides had significantly lower serum zinc concentrations (p=0.039), while children with T.trichiura had slightly lower serum zinc concentrations (p=0.659) than before treatment. ConclusionsAlbendazole treatment produces lower serum zinc concentration in elementary school children with A.lumbricoides infections. A profound understanding of the interaction between helminth infections and zinc may assist in guiding integrated and sustainable intervention strategies among affected children throughout the world.

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  • University of Indonesia
  • Universitas Trisakti
  • Tarumanagara University
  • Sekolah Tinggi Ilmu Kesehatan Yogyakarta
  • Universitas Airlangga
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Rekan penulisOrganisasiArtikel bersama
Tri Yunis Miko WahyonoUniversity of Indonesia1
Kholisotul HikmahUniversity of Indonesia1
Ikrimah NafilataSekolah Tinggi Ilmu Kesehatan Yogyakarta1
Nurhayati Adnan PrihartonoUniversity of Indonesia1
Yuli Puspita DeviUniversitas Airlangga1
Heri WibowoUniversity of Indonesia1
Suriyani TanUniversitas Trisakti1

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Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Albendazole therapy reduces serum zinc in elementary school children with Ascaris lumbricoides infections</dc:title>
	<dc:creator xml:lang="en">Buana, Ria</dc:creator>
	<dc:creator xml:lang="en">Kalumpiu, Jane Florida</dc:creator>
	<dc:creator xml:lang="en">Djuardi, Yenny</dc:creator>
	<dc:creator xml:lang="en">Supali, Taniawati</dc:creator>
	<dc:subject xml:lang="en">Serum zinc</dc:subject>
	<dc:subject xml:lang="en">albendazole</dc:subject>
	<dc:subject xml:lang="en">STH</dc:subject>
	<dc:subject xml:lang="en">children</dc:subject>
	<dc:description xml:lang="en">BackgroundSoil-transmitted helminth (STH) infection can cause malnutrition and vice versa, and decrease serum zinc concentrations. No previous studies were found on the effect of STH treatment on serum zinc concentrations in elementary school children. The objective of this study was to evalaute the effect of STH treatment on serum zinc concentration in elementary school children in Jakarta. MethodsA pre-experimental study (one group pre and post) was conducted on 3rd - 5th grade students in one elementary school in North Jakarta. FLOTAC examination was used to determine infection status and STH intensity, while serum zinc concentrations were measured by atomic absorption spectrometry. All children were given albendazole 400 mg for three consecutive days. Stool and blood samples were collected before and three weeks after treatment with albendazole. A paired t test was used to analyze the data. ResultsThe STH prevalence was 63.4%; these were mainly Ascaris lumbricoides and Trichuris trichiura infections. Before treatment, children infected with A.lumbricoides and T.trichiura had significantly higher serum zinc concentrations (p=0.028; p=0.014). After treatment, children with A.lumbricoides had significantly lower serum zinc concentrations (p=0.039), while children with T.trichiura had slightly lower serum zinc concentrations (p=0.659) than before treatment. ConclusionsAlbendazole treatment produces lower serum zinc concentration in elementary school children with A.lumbricoides infections. A profound understanding of the interaction between helminth infections and zinc may assist in guiding integrated and sustainable intervention strategies among affected children throughout the world.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2016-12-06</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/254</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2016.v35.206-212</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 35 No. 3 (2016); 206-212</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:source>10.18051/UnivMed.2016.v35.i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/254/378</dc:relation>
	<dc:relation>10.18051/univmed.v35i3.254</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2016 Ria Buana, Jane Florida Kalumpiu, Yenny Djuardi, Taniawati Supali</dc:rights>
</oai_dc:dc>