Smoking tends to decrease glutathione and increase malondialdehyde levels in medical students

Safyudin, Safyudin; Subandrate, Subandrate

doi:10.18051/UnivMed.2016.v35.89-95

Jurnal SINTA 1

Smoking tends to decrease glutathione and increase malondialdehyde levels in medical students

Universa Medicina · Vol. 35 No. 2 (2016) · hlm. 89–95

DOI: 10.18051/UnivMed.2016.v35.89-95
ISSN: 2407-2230, 1907-3062
Terbit: 2016-08-08
Penerbit: Faculty of Medicine, Universitas Trisakti
Bahasa: eng

Abstrak

BackgroundSmoking is the act of introducing toxic substances into the body. Cigarette smoke contains chemicals that may cause several disorders, including cardiovascular disease, cancer, and chronic obstructive pulmonary disease. Toxic substances in cigarette smoke have the potential to increase free radicals, malondialdehyde (MDA) levels and to decrease endogenous antioxidant (glutathione/GSH) levels. This study aims to determine the relationship of smoking with plasma GSH and MDA levels in medical students.MethodsThis study was analytical observational with cross-sectional approach. The study was conducted from April to December 2015. The subjects in this study were medical students, consisting of 20 smokers and 20 nonsmokers. Plasma GSH and MDA levels were determined biochemically using Sigma GSH Assay Kit and Sigma MDA Assay Kit. Data was analyzed using the independent t test. ResultsThe results showed that there was no significant difference between mean GSH in smokers (1.74 ± 0.91 mmol/L) and nonsmokers (2.42 ± 1.19 µmol/L) (p=0.441). Mean smokers MDA level of 2.06 ± 1.39 nmol/mL was not significantly different compared with mean nonsmokers MDA level (1.32 ± 0.90 nmol/mL) (p=0.092).ConclusionsSmoking tends to decrease plasma GSH levels and increase plasma MDA levels in medical students. Smoking history could be evidence of oxidative stress and an impaired oxidant defense system. In particular, young smokers should quit promptly before health problems arise, so as to have the optimal benefits of cessation.

Kata kunci

Jaringan kolaborasi para penulis

11 penulis · 28 tautan kepenulisan bersama · 10 lintas organisasi

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

Sriwijaya University
University of Indonesia
Afiliasi tidak diketahui

Organisasi berbeda
Organisasi sama
Afiliasi tidak diketahui
Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel

Tampilkan sebagai tabel

Rekan penulis	Organisasi	Artikel bersama
Mgs. M. Irsan Saleh	Sriwijaya University	1
Mohamad Sadikin	University of Indonesia	1
Dwirini Retno Gunarti	University of Indonesia	1
Hermansyah Hermansyah	Sriwijaya University	1
Zen Hafy	Sriwijaya University	1
Yudianita Kesuma	Sriwijaya University	1
Mia Esta Poetri Afdal Faisal	Afiliasi tidak diketahui	1
Nurul Windi Anggraini	Sriwijaya University	1
Sadakata Sinulingga	Sriwijaya University	1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.

Metadata asli (oai_dc)

<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Smoking tends to decrease glutathione and increase malondialdehyde levels in medical students</dc:title>
	<dc:creator xml:lang="en">Safyudin, Safyudin</dc:creator>
	<dc:creator xml:lang="en">Subandrate, Subandrate</dc:creator>
	<dc:subject xml:lang="en">Free radicals</dc:subject>
	<dc:subject xml:lang="en">GSH</dc:subject>
	<dc:subject xml:lang="en">MDA</dc:subject>
	<dc:subject xml:lang="en">smoking</dc:subject>
	<dc:subject xml:lang="en">medical students</dc:subject>
	<dc:description xml:lang="en">BackgroundSmoking is the act of introducing toxic substances into the body. Cigarette smoke contains chemicals that may cause several disorders, including cardiovascular disease, cancer, and chronic obstructive pulmonary disease. Toxic substances in cigarette smoke have the potential to increase free radicals, malondialdehyde (MDA) levels and to decrease endogenous antioxidant (glutathione/GSH) levels. This study aims to determine the relationship of smoking with plasma GSH and MDA levels in medical students.MethodsThis study was analytical observational with cross-sectional approach. The study was conducted from April to December 2015. The subjects in this study were medical students, consisting of 20 smokers and 20 nonsmokers. Plasma GSH and MDA levels were determined biochemically using Sigma GSH Assay Kit and Sigma MDA Assay Kit. Data was analyzed using the independent t test. ResultsThe results showed that there was no significant difference between mean GSH in smokers (1.74 ± 0.91 mmol/L) and nonsmokers (2.42 ± 1.19 µmol/L) (p=0.441). Mean smokers MDA level of 2.06 ± 1.39 nmol/mL was not significantly different compared with mean nonsmokers MDA level (1.32 ± 0.90 nmol/mL) (p=0.092).ConclusionsSmoking tends to decrease plasma GSH levels and increase plasma MDA levels in medical students. Smoking history could be evidence of oxidative stress and an impaired oxidant defense system. In particular, young smokers should quit promptly before health problems arise, so as to have the optimal benefits of cessation.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2016-08-08</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:format>application/pdf</dc:format>
	<dc:format>application/pdf</dc:format>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/326</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2016.v35.89-95</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 35 No. 2 (2016); 89-95</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:source>10.18051/UnivMed.2016.v35.i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/326/391</dc:relation>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/326/623</dc:relation>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/326/625</dc:relation>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/326/626</dc:relation>
	<dc:relation>10.18051/univmed.v35i2.326</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2016 Safyudin Safyudin, Subandrate Subandrate</dc:rights>
</oai_dc:dc>