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Body mass index increases CD4+ count in HIV/AIDS patients on first-line therapy

Universa Medicina · Vol. 39 No. 2 (2020) · hlm. 121–127

DOI
10.18051/UnivMed.2020.v39.121-127
ISSN
2407-2230, 1907-3062
Terbit
2020-08-13
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng

Abstrak

BackgroundThe body mass index (BMI) may contribute somewhat to drug metabolism, thus affecting the efficacy of antiretroviral therapy (ART). CD4+ counts in people infected with HIV are essential in determining the stage of the disease, initiation of antiretroviral therapy, opportunistic infections and evaluating treatment outcomes. The aim of this study was to determine the association of BMI and clinical stage with CD4+ counts in HIV patients seeking treatment using first-line antiretroviral therapy (ART).MethodsAn analytic study with a cross-sectional approach was conducted involving 251 HIV/AIDS patients who had received first-line antiretrovirals over six months. BMI, clinical staging according to WHO and CD4 + were collected. Multiple linear regression was used to evaluate the relationship between BMI, clinical stage and CD4+.ResultsAmong the enrolled patients, the median age was 36 years, 135 (55%) of the patients was female, 102 (40.6%) was overweight/obese, 161 (64.1%) was in stage 3 of the disease, and the median CD4+ count was 389 cells/mm3. Multiple linear regression test showed two variables with a significant effect on CD4+ count, namely BMI (B=69.247; 95 % CI: 42.886-95.608) and clinical stage (B=61.590; 28.910-94.270). BMI was the most influencing factor for CD4+ count (β=0.307) compared to clinical stage (β=0.216). ConclusionsBody mass index was the most influencing factor for CD4 + counts of HIV/AIDS patients. Regular ART can increase CD4+ counts and maintain the health of HIV/AIDS patients.

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  • Kementerian Kesehatan Republik Indonesia
  • UIN Sunan Ampel Surabaya
  • Universitas Airlangga
  • Indonesian Institute of Sciences
  • National Research and Innovation Agency
  • Cenderawasih University
  • Universitas Widya Kartika
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Rekan penulisOrganisasiArtikel bersama
Dedy SuprayogiUIN Sunan Ampel Surabaya5
Muhammad Yusuf AlamudiAfiliasi tidak diketahui3
Holy Arif WibowoKementerian Kesehatan Republik Indonesia2
Eva FitrianaAfiliasi tidak diketahui2
Yustinus MaladanAfiliasi tidak diketahui2
Antonius OktavianCenderawasih University2
Hotma HutapeaAfiliasi tidak diketahui1
Semuel SandiAfiliasi tidak diketahui1
Muhammad Falikhul Musyaffa'UIN Sunan Ampel Surabaya1
Kartika DewiIndonesian Institute of Sciences1
Nanang SupriatnaIndonesian Institute of Sciences1
Hotma Martogi Lorensi HutapeaNational Research and Innovation Agency1
Yunita MirinoAfiliasi tidak diketahui1
Khuliyah Candraning DiyanahUniversitas Airlangga1
Izza MahendraUniversitas Airlangga1
Sigit Ari SaputroUniversitas Airlangga1
Syahrul Afifa Ratna SariKementerian Kesehatan Republik Indonesia1
Teguh Taruna UtamaUIN Sunan Ampel Surabaya1
Tri Sunan AgungUniversitas Widya Kartika1
Ziadatur RizqiyahInstitut Teknologi Sepuluh Nopember1
Yudied Agung MirasaKementerian Kesehatan Republik Indonesia1
Soedjajadi KemanUniversitas Airlangga1
Haidar Rafli Putra SuhardiUIN Sunan Ampel Surabaya1
Atiqoh ZummahUIN Sunan Ampel Surabaya1
Clara ImaniarAfiliasi tidak diketahui1
Tri WibawaUniversitas Gadjah Mada1
Reynold Rizal UbraAfiliasi tidak diketahui1
Hanna S. I. KawulurAfiliasi tidak diketahui1
Semuel SandyNational Research and Innovation Agency1
Iman H S SastoAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Body mass index increases CD4+ count in HIV/AIDS patients on first-line therapy</dc:title>
	<dc:creator xml:lang="en">Widiyanti, Mirna</dc:creator>
	<dc:creator xml:lang="en">Hadi, Moch Irfan</dc:creator>
	<dc:creator xml:lang="en">Kumalasari, Mei Lina Fitri</dc:creator>
	<dc:creator xml:lang="en">Natalia, Evi Iriani</dc:creator>
	<dc:creator xml:lang="en">Purba, Dedi Ananta</dc:creator>
	<dc:creator xml:lang="en">Adiningsih, Setyo</dc:creator>
	<dc:subject xml:lang="en">CD4   count</dc:subject>
	<dc:subject xml:lang="en">body mass index</dc:subject>
	<dc:subject xml:lang="en">clinical staging</dc:subject>
	<dc:subject xml:lang="en">HIV patients</dc:subject>
	<dc:subject xml:lang="en">CD4   count</dc:subject>
	<dc:description xml:lang="en">BackgroundThe body mass index (BMI) may contribute somewhat to drug metabolism, thus affecting the efficacy of antiretroviral therapy (ART). CD4+ counts   in people infected with HIV are essential in determining the stage of the disease, initiation of antiretroviral therapy, opportunistic infections and evaluating treatment outcomes. The aim of this study was to determine the association of BMI and clinical stage with CD4+ counts in HIV patients seeking treatment using first-line antiretroviral therapy (ART).MethodsAn analytic study with a cross-sectional approach was conducted involving 251 HIV/AIDS patients who had received first-line antiretrovirals over six months. BMI, clinical staging according to WHO and CD4 + were collected. Multiple linear regression was used to evaluate the relationship between BMI, clinical stage and CD4+.ResultsAmong the enrolled patients, the median age was 36 years, 135 (55%) of the patients was female, 102 (40.6%) was overweight/obese, 161 (64.1%) was in stage 3 of the disease, and the median CD4+ count was 389 cells/mm3. Multiple linear regression test showed two variables with a significant effect on CD4+ count, namely BMI (B=69.247; 95 % CI : 42.886-95.608) and clinical stage (B=61.590; 28.910-94.270). BMI was the most influencing factor for CD4+ count (β=0.307) compared to clinical stage (β=0.216). ConclusionsBody mass index was the most influencing factor for CD4 + counts of HIV/AIDS patients. Regular ART can increase CD4+ counts and maintain the health of HIV/AIDS patients.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2020-08-13</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/1018</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2020.v39.121-127</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 39 No. 2 (2020); 121-127</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:source>10.18051/UnivMed.2020.v39.i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/1018/593</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2020 Mirna Widiyanti, Moch Irfan Hadi, Mei Lina Fitri, Evi Iriani Natalia, Dedi Ananta Purba, Setyo Adiningsih</dc:rights>
</oai_dc:dc>