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Hepatoprotective activity of Averrhoa bilimbi L. fruit extract on carbon tetrachloride-induced acute liver faiure in Wistar rats

Universa Medicina · Vol. 42 No. 1 (2023) · hlm. 61–69

DOI
10.18051/UnivMed.2023.v42.61-69
ISSN
2407-2230, 1907-3062
Terbit
2023-04-10
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

Background Acute liver failure (ALF) is a state of rapid and progressive deterioration of liver function. Continuous exposure to chemicals and viruses can increase reactive oxygen species (ROS) which leads to prolonged inflammation due to the production of tumor necrosis factor-alpha (TNF-á) thus inhibiting the production of platelet-derived growth factor (PDGF). The objective of this study was to evaluate the effect of administration of Averrhoa bilimbi L. fruit extract on PDGF levels and TNF-á levels in carbon tetrachloride (CCl4)-induced ALF rats. MethodsThis study used a post-test-only control group design involving 20 Wistar rats. They were randomized into 4 groups, namely sham, control, T1, and T2. Group T1 was exposed to CCl4 with the administration of A. bilimbi fruit extract at a dose of 500mg/kgBW, while, group T2 was exposed to CCl4 and given A. bilimbi fruit extract of 750 mg/kgBW. On the 15th day, the serum was analyzed to determine the levels of PDGF and TNF-á using ELISA. ResultsThe highest mean PDGF level in the control group was 146.60±15.36 pg/mL, while the highest mean TNF-á level in group T1 was 40.11±4.44 pg/mL. The One-way ANOVA test showed that there were significant differences in TNF-á (p=0.002) and PDGF (p=0.000) levels between the study groups. ConclusionThe administration of A.bilimbi L. fruit extract affected PDGF and TNF-á levels in CCl4-induced ALF rats. The present study revealed that A. bilimbi fruits have significant hepatoprotective activity in experimental Wistar rats.

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  • Sultan Agung Islamic University
  • Universitas Sumatera Utara
  • State University of Semarang
  • Soegijapranata Catholic University
  • University of Mataram
  • Diponegoro University
  • Universitas Prima Indonesia
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Rekan penulisOrganisasiArtikel bersama
Nur Dina AmalinaState University of Semarang4
Setyo TrisnadiSultan Agung Islamic University4
Salma Yasmine AzzaharaSultan Agung Islamic University4
Risky Chandra Satria IrawanSultan Agung Islamic University4
Nurul HidayahSultan Agung Islamic University3
Iffan AlifSultan Agung Islamic University3
Bayu Tirta DirjaUniversity of Mataram3
Sugeng IbrahimSoegijapranata Catholic University3
Adi Muradi MuharUniversitas Sumatera Utara2
Alisia Martha DewiSultan Agung Islamic University2
Setyo TrisnasiSultan Agung Islamic University2
Hadi SarosaSultan Agung Islamic University2
Sri Priyantini MulyaniSultan Agung Islamic University2
Riska RachmaniaSultan Agung Islamic University2
Sofian Azalia HusainAfiliasi tidak diketahui2
Ade Indra MuktiUniversitas Prima Indonesia2
Reynaldi SuryajayaAfiliasi tidak diketahui2
Ratnawati RatnawatiSultan Agung Islamic University1
Atina HussaanaSultan Agung Islamic University1
Faizal MukharimSultan Agung Islamic University1
Dedy HermansyahUniversitas Sumatera Utara1
Yan Wisnu PrajokoDiponegoro University1
Pangesti DrawinaSultan Agung Islamic University1
Taufiqurrachman NasihunSultan Agung Islamic University1
Nur Anna Chalimah Sa'dyahAfiliasi tidak diketahui1
Chodidjah ChodidjahSultan Agung Islamic University1
Hadi SunartoSultan Agung Islamic University1
Arya TjiptaUniversitas Sumatera Utara1
Joko WahyuwibowoSultan Agung Islamic University1
Arrizki Azka PratamaSultan Agung Islamic University1
Sahara MaharaniSultan Agung Islamic University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Hepatoprotective activity of Averrhoa bilimbi L. fruit  extract on carbon tetrachloride-induced  acute liver faiure in Wistar rats</dc:title>
	<dc:creator xml:lang="en">Sihaloho , Rachellicya Ristioni </dc:creator>
	<dc:creator xml:lang="en">Chodijah, Chodijah</dc:creator>
	<dc:creator xml:lang="en">Sumarawati, Titiek </dc:creator>
	<dc:creator xml:lang="en">Wibowo, Joko Wahyu </dc:creator>
	<dc:creator xml:lang="en">Zulaikhah, Siti Thomas</dc:creator>
	<dc:creator xml:lang="en">Putra, Agung</dc:creator>
	<dc:creator xml:lang="en">Hidayah, Nurul</dc:creator>
	<dc:creator xml:lang="en">Ghaissani, Shabrina Syifa</dc:creator>
	<dc:creator xml:lang="en">Nazar, Mohammad Ariq </dc:creator>
	<dc:subject xml:lang="en">Acute liver failure</dc:subject>
	<dc:subject xml:lang="en">Averrhoa bilimbi L.</dc:subject>
	<dc:subject xml:lang="en">reactive oxygen species</dc:subject>
	<dc:subject xml:lang="en">rat</dc:subject>
	<dc:description xml:lang="en">Background Acute liver failure (ALF) is a state of rapid and progressive deterioration of liver function. Continuous exposure to chemicals and viruses can increase reactive oxygen species (ROS) which leads to prolonged inflammation due to the production of tumor necrosis factor-alpha (TNF-á) thus inhibiting the production of platelet-derived growth factor (PDGF). The objective of this study was to evaluate the effect of administration of Averrhoa bilimbi L. fruit extract on PDGF levels and TNF-á levels in carbon tetrachloride (CCl4)-induced ALF rats.
MethodsThis study used a post-test-only control group design involving 20 Wistar rats. They were randomized into 4 groups, namely sham, control, T1, and T2. Group T1 was exposed to CCl4 with the administration of A. bilimbi fruit extract at a dose of 500mg/kgBW, while, group T2 was exposed to CCl4 and given A. bilimbi fruit extract of 750 mg/kgBW. On the 15th day, the serum was analyzed to determine the levels of PDGF and TNF-á using ELISA.
ResultsThe highest mean PDGF level in the control group was 146.60±15.36 pg/mL, while the highest mean TNF-á level in group T1 was 40.11±4.44 pg/mL. The One-way ANOVA test showed that there were significant differences in TNF-á (p=0.002) and PDGF (p=0.000) levels between the study groups.
ConclusionThe administration of A.bilimbi L. fruit extract affected PDGF and TNF-á levels in CCl4-induced ALF rats. The present study revealed that A. bilimbi fruits have significant hepatoprotective activity in experimental Wistar rats.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2023-04-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/1370</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2023.v42.61-69</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 42 No. 1 (2023); 61-69</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:source>10.18051/UnivMed.2023.v42.i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/1370/733</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2023 Rachellicya Ristioni  Sihaloho , Chodijah Chodijah, Titiek  Sumarawati, Joko Wahyu  Wibowo, Siti Thomas Zulaikhah, Agung Putra, Nurul Hidayah, Shabrina Syifa Ghaissani, Mohammad Ariq  Nazar</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>