Melola Discovery

← Melola Discovery

Akses terbuka Jurnal SINTA 1

Comparison of natural versus artificial cycles for endometrial preparation prior to frozen embryo transfer

Universa Medicina · Vol. 43 No. 3 (2024) · hlm. 304–312

DOI
10.18051/UnivMed.2024.v43.304-312
ISSN
2407-2230, 1907-3062
Terbit
2024-11-25
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

BackgroundThe endometrial preparation phase preceding embryo transfer assumes pivotal significance in achieving optimal endometrial receptivity and ensuring the success of pregnancy. The natural cycle (NC) and artificial cycle (AC) are the preferred methods for many in vitro fertilization (IVF) specialists. The objective of this study was to compare the difference between NC and AC in women undergoing frozen-thawed embryo transfer (FET) after IVF. MethodsA cross-sectional study was conducted involving 150 adult women who underwent FET with a single autologous blastocyst stage embryo in a 5-year period (2014-2019). Bivariate analysis was conducted to discern implantation and pregnancy rates associated with NC and AC for endometrial preparation. Multiple logistic regression was used to assess the association between endometrial preparation and clinical outcomes while adjusting for potential confounders. ResultsOf the 150 subjects meeting study criteria, 19 underwent NC, while 131 underwent AC for endometrial preparation. Natural cycle exhibited a higher biochemical pregnancy rates compared to AC (89.5% vs. 53.4%; p=0.003). Artificial cycle is a significant determinant for biochemical pregnancy rates compared to NC (aOR: 0.132;95% CI: 0.028 – 0.623; p=0.010) ConclusionIn women undergoing FET, NC resulted in higher biochemical pregnancy rates compared to AC. However, clinical pregnancy rates and ongoing pregnancies rates did not exhibit significant disparities between NC and AC. Future studies will hopefully further illuminate which protocol is most suitable for the individual patient. Further multi-center randomized clinical trials are needed to confirm the relationship between biochemical pregnancy rates and NC.

Kata kunci

Jaringan kolaborasi para penulis

13 penulis · 51 tautan kepenulisan bersama

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Muhammad Rizkinov JumsaRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo1
Tricia Dewi AnggraeniRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo1
Tantri HellyantiRumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Comparison of natural versus artificial cycles for endometrial preparation prior to frozen embryo transfer</dc:title>
	<dc:creator xml:lang="en">Tyagitha, Galuh Anindya</dc:creator>
	<dc:creator xml:lang="en">Nuryanto, Kartiwa Hadi</dc:creator>
	<dc:creator xml:lang="en">Pratama, Gita</dc:creator>
	<dc:creator xml:lang="en">Maidarti, Mila</dc:creator>
	<dc:creator xml:lang="en">Harzif, Achmad Kemal</dc:creator>
	<dc:creator xml:lang="en">Sumapraja, Kanadi </dc:creator>
	<dc:creator xml:lang="en">Lestari, Silvia Werdhy </dc:creator>
	<dc:creator xml:lang="en">Ampri, Irfan Arieqal Hatta </dc:creator>
	<dc:creator xml:lang="en">Talya, Natasha</dc:creator>
	<dc:creator xml:lang="en">Yanfaunas, Atika Mahira</dc:creator>
	<dc:subject xml:lang="en">Infertility</dc:subject>
	<dc:subject xml:lang="en">IVF</dc:subject>
	<dc:subject xml:lang="en">frozen embryo transfer</dc:subject>
	<dc:subject xml:lang="en">natural</dc:subject>
	<dc:subject xml:lang="en">hormone replacement</dc:subject>
	<dc:subject xml:lang="en">biochemical pregnancy rates</dc:subject>
	<dc:description xml:lang="en">BackgroundThe endometrial preparation phase preceding embryo transfer assumes pivotal significance in achieving optimal endometrial receptivity and ensuring the success of pregnancy. The natural cycle (NC) and artificial cycle (AC) are the preferred methods for many in vitro fertilization (IVF) specialists. The objective of this study was to compare the difference between NC and AC in women undergoing frozen-thawed embryo transfer (FET) after IVF.
MethodsA cross-sectional study was conducted involving 150 adult women who underwent FET with a single autologous blastocyst stage embryo in a 5-year period (2014-2019). Bivariate analysis was conducted to discern implantation and pregnancy rates associated with NC and AC for endometrial preparation. Multiple logistic regression was used to assess the association between endometrial preparation and clinical outcomes while adjusting for potential confounders.
ResultsOf the 150 subjects meeting study criteria, 19 underwent NC, while 131 underwent AC for endometrial preparation. Natural cycle exhibited a higher biochemical pregnancy rates compared to AC (89.5% vs. 53.4%; p=0.003). Artificial cycle is a significant determinant for biochemical pregnancy rates compared to NC (aOR: 0.132;95% CI: 0.028 – 0.623; p=0.010)
ConclusionIn women undergoing FET, NC resulted in higher biochemical pregnancy rates compared to AC. However, clinical pregnancy rates and ongoing pregnancies rates did not exhibit significant disparities between NC and AC. Future studies will hopefully further illuminate which protocol is most suitable for the individual patient. Further multi-center randomized clinical trials are needed to confirm the relationship between biochemical pregnancy rates and NC.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2024-11-25</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/1622</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2024.v43.304-312</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 43 No. 3 (2024); 304-312</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/1622/801</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Galuh Anindya Tyagitha, Kartiwa Hadi Nuryanto, Gita Pratama, Mila Maidarti, Achmad Kemal Harzif, Kanadi  Sumapraja, Silvia Werdhy  Lestari, Irfan Arieqal Hatta  Ampri, Natasha Talya, Atika Mahira Yanfaunas</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>