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Umbilical cord mesenchymal stem cells and their secretome: a new frontier in orthopedic medicine

Universa Medicina · Vol. 45 No. 1 (2026) · hlm. 135–152

DOI
10.18051/UnivMed.2026.v45.135-152
ISSN
2407-2230, 1907-3062
Terbit
2026-04-22
Penerbit
Faculty of Medicine, Universitas Trisakti
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

Umbilical cord mesenchymal stem cells (UC-MSCs) have gained significant attention in regenerative medicine due to their unique biological properties, including high proliferation capacity, low immunogenicity, and potent immunomodulatory effects. These characteristics make UC-MSCs particularly promising for orthopedic applications, where the repair and regeneration of musculoskeletal tissues such as bone, cartilage, tendons, ligaments, and nerves are critical for restoring function. The secretome of UC-MSCs—comprising bioactive molecules such as exosomes, cytokines, and growth factors—offers a powerful, cell-free therapeutic option through paracrine signaling, further enhancing their therapeutic potential. A literature search was conducted in major databases (PubMed, ScienceDirect, SpringerLink, Google Scholar) for English articles from 2010–2025 using keywords related to UC‑MSCs and orthopedic regeneration. This review explores the role of UC-MSCs and their secretome in orthopedic tissue repair, focusing on their application in bone healing, cartilage regeneration, tendon-ligament repair, and nerve regeneration with their innovative delivery. Despite the promising potential of UC-MSC therapies, several challenges remain, including regulatory hurdles, long-term safety concerns, and the scalability of cell-based and secretome-based therapies for widespread clinical use. Although umbilical cord MSCs are not yet widely applied in clinical practice, increasing evidence suggests that they offer significant therapeutic potential, especially in the treatment of autoimmune and neurodegenerative diseases. The UC-MSCs and their secretome represent a transformative approach in orthopedics, offering new avenues for treating complex musculoskeletal injuries and degenerative diseases. Ongoing advancements in this field will likely unlock their full potential, making them viable options for clinical use in the near future.

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  • Sebelas Maret University
  • RSO Soeharso Surakarta
  • Universitas Gadjah Mada
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
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Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Pamudji UtomoRSO Soeharso Surakarta4
M qathar Rf Tulandi TulandiSebelas Maret University3
Fajar Ivan EffendiSebelas Maret University1
Rieva ErnawanAfiliasi tidak diketahui1
Ismail MariyantoAfiliasi tidak diketahui1
Bayu Sakti JiwandonoAfiliasi tidak diketahui1
Agus WahyudiAfiliasi tidak diketahui1
Rahmad RianSebelas Maret University1
Seti Aji HadinotoRSO Soeharso Surakarta1
Arie KAfiliasi tidak diketahui1
Leli SabariyahAfiliasi tidak diketahui1
Yuni Prasetyo KurniatiAfiliasi tidak diketahui1
Karina Pratiwi PutriAfiliasi tidak diketahui1
Rike RayantiAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://univmed.org/ejurnal/index.php/medicina/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Umbilical cord mesenchymal stem cells and their secretome: a new frontier in orthopedic medicine</dc:title>
	<dc:creator xml:lang="en">Sumarwoto, Tito</dc:creator>
	<dc:creator xml:lang="en">Romaniyanto</dc:creator>
	<dc:creator xml:lang="en">Rhamtomy, Sholahuddin</dc:creator>
	<dc:creator xml:lang="en">Idulhaq, Mujaddid</dc:creator>
	<dc:creator xml:lang="en">Santoso, Asep</dc:creator>
	<dc:subject xml:lang="en">Umbilical cord-mesenchymal stem cells (UC-MSCs)</dc:subject>
	<dc:subject xml:lang="en">secretome</dc:subject>
	<dc:subject xml:lang="en">orthopedics</dc:subject>
	<dc:subject xml:lang="en">neurodegenerative diseases</dc:subject>
	<dc:description xml:lang="en">Umbilical cord mesenchymal stem cells (UC-MSCs) have gained significant attention in regenerative medicine due to their unique biological properties, including high proliferation capacity, low immunogenicity, and potent immunomodulatory effects. These characteristics make UC-MSCs particularly promising for orthopedic applications, where the repair and regeneration of musculoskeletal tissues such as bone, cartilage, tendons, ligaments, and nerves are critical for restoring function. The secretome of UC-MSCs—comprising bioactive molecules such as exosomes, cytokines, and growth factors—offers a powerful, cell-free therapeutic option through paracrine signaling, further enhancing their therapeutic potential. A literature search was conducted in major databases (PubMed, ScienceDirect, SpringerLink, Google Scholar) for English articles from 2010–2025 using keywords related to UC‑MSCs and orthopedic regeneration. This review explores the role of UC-MSCs and their secretome in orthopedic tissue repair, focusing on their application in bone healing, cartilage regeneration, tendon-ligament repair, and nerve regeneration with their innovative delivery. Despite the promising potential of UC-MSC therapies, several challenges remain, including regulatory hurdles, long-term safety concerns, and the scalability of cell-based and secretome-based therapies for widespread clinical use. Although umbilical cord MSCs are not yet widely applied in clinical practice, increasing evidence suggests that they offer significant therapeutic potential, especially in the treatment of autoimmune and neurodegenerative diseases. The UC-MSCs and their secretome represent a transformative approach in orthopedics, offering new avenues for treating complex musculoskeletal injuries and degenerative diseases. Ongoing advancements in this field will likely unlock their full potential, making them viable options for clinical use in the near future.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Medicine, Universitas Trisakti</dc:publisher>
	<dc:date>2026-04-22</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://univmed.org/ejurnal/index.php/medicina/article/view/1844</dc:identifier>
	<dc:identifier>10.18051/UnivMed.2026.v45.135-152</dc:identifier>
	<dc:source xml:lang="en">Universa Medicina; Vol. 45 No. 1 (2026); 135-152</dc:source>
	<dc:source>2407-2230</dc:source>
	<dc:source>1907-3062</dc:source>
	<dc:source>10.18051/UnivMed.2026.v45.i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://univmed.org/ejurnal/index.php/medicina/article/view/1844/865</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Tito Sumarwoto, Romaniyanto, Sholahuddin Rhamtomy, Mujaddid Idulhaq, Asep Santoso</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>