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Jurnal SINTA 1

Profil Fraksi Sitotoksik terhadap Sel Murine Leukemia P-388 dari Ekstrak Biji Honje (Etlingera elatior)

VALENSI · Vol. ume No. 1 (2017) · hlm. 79–87

DOI
10.15408/jkv.v3i1.3640
ISSN
2548-3013, 2460-6065
Terbit
2017-05-31
Penerbit
Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University
Bahasa
eng

Abstrak

The research characterization of cytotoxic fraction against P-388 leukemia murine cells from the extract honje (Etlingera elatior) seed have been reported. This research lead to isolated and characterization of cytotoxic compounds against P-388 leukemia murine cells from the extract E. elantior seed. The extract of E. elantior seed was maserated by methanol, n-hexane, and ethyl acetate, respectively and estimated their cytotoxic activity against P-388 leukemia murine cell with 3- (4, 5-dimetiltiazol-2-yl) -2,5-difeniltetrazolium bromide (MTT) assay guided toxicity test against of shrimp Artemia salina Leach. Brine shirmp Lethality Test (BSLT) method. The active extracts will be separated by fractionation using column chromatography, radial chromatography, and for analyzing the purity of isolate will estimate by HPLC. The chemical structure of pure isolate will be identified by spectroscopies data UV Vis, FTIR, NMR and MS. The ethyl acetate extract from honje seed have cytotoxic activity by leukemia P-388 cell with IC50 19.21 µg/mL. The compound toxic as cytotoxicagainst P-388 leukemia murine cells is flavonoid compouds their is resveratrol, lapachol, apigenin, methylated chrysin, 6,2’-dihydroxyflavanone, 3-hydroxy-3,4’-dymethoxyflavone and 4’-hydroxy-5,7-dimethoxyflavanone.DOI: http://dx.doi.org/10.15408/jkv.v0i0.3640

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  • Syarif Hidayatullah State Islamic University Jakarta
  • University of Indonesia
  • National Nuclear Energy Agency of Indonesia
  • Universitas Mathla'ul Anwar Banten
  • Badan Pengkajian dan Penerapan Teknologi
  • Universitas Halu Oleo
  • Sunan Kalijaga State Islamic University Yogyakarta
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Rekan penulisOrganisasiArtikel bersama
Agustino ZulysUniversity of Indonesia13
Nanda SaridewiSyarif Hidayatullah State Islamic University Jakarta9
Siti NurbaytiSyarif Hidayatullah State Islamic University Jakarta9
Sandra HermantoSyarif Hidayatullah State Islamic University Jakarta8
Nani RadiastutiSyarif Hidayatullah State Islamic University Jakarta5
Isalmi AzizSyarif Hidayatullah State Islamic University Jakarta5
Anna MuawanahSyarif Hidayatullah State Islamic University Jakarta5
Eka Rizki AmeliaSyarif Hidayatullah State Islamic University Jakarta4
Ahmad FathoniSyarif Hidayatullah State Islamic University Jakarta4
Nurhasni NurhasniSyarif Hidayatullah State Islamic University Jakarta4
La Ode SumarlinSyarif Hidayatullah State Islamic University Jakarta3
Muhammad Shofyan GunawanSyarif Hidayatullah State Islamic University Jakarta3
Sri KomalaSyarif Hidayatullah State Islamic University Jakarta3
Latifah TulhusnaSyarif Hidayatullah State Islamic University Jakarta3
Rizkha FadhillaSyarif Hidayatullah State Islamic University Jakarta3
Wulandari OktaviaSyarif Hidayatullah State Islamic University Jakarta2
Farhan Maulana AzharSyarif Hidayatullah State Islamic University Jakarta2
Risma Nur FitriaSyarif Hidayatullah State Islamic University Jakarta2
Jarnuzi GunlazuardiUniversity of Indonesia2
Muhammad Derry Luthfi YudhiUniversity of Indonesia2
Ira JayanegaraBadan Pengkajian dan Penerapan Teknologi2
Adeng HudayaSyarif Hidayatullah State Islamic University Jakarta2
Sri Yadial ChalidSyarif Hidayatullah State Islamic University Jakarta2
Lailatul BadriyahSyarif Hidayatullah State Islamic University Jakarta2
Wawan RustyawanPertamina (Indonesia)2
Uly Fitria BaleSyarif Hidayatullah State Islamic University Jakarta2
Rizka FadhillaSyarif Hidayatullah State Islamic University Jakarta2
Teguh WahyonoNational Nuclear Energy Agency of Indonesia1
Widhi KurniawanUniversitas Halu Oleo1
Rista Kurnia DewiSyarif Hidayatullah State Islamic University Jakarta1
Sihono SihonoNational Nuclear Energy Agency of Indonesia1
Fuady HaniefSyarif Hidayatullah State Islamic University Jakarta1
Lia PratiwiSyarif Hidayatullah State Islamic University Jakarta1
Asih Widi WisudawatiSunan Kalijaga State Islamic University Yogyakarta1
Muhammad Ihda H.L. ZeinSyarif Hidayatullah State Islamic University Jakarta1
Selviana RustantiSyarif Hidayatullah State Islamic University Jakarta1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.uinjkt.ac.id/index.php/valensi/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Profil Fraksi Sitotoksik terhadap Sel Murine Leukemia P-388 dari Ekstrak Biji Honje (Etlingera elatior)</dc:title>
	<dc:creator xml:lang="en">Rusanti, Alfindah</dc:creator>
	<dc:creator xml:lang="en">Sukandar, Dede</dc:creator>
	<dc:creator xml:lang="en">Rudiana, Tarso</dc:creator>
	<dc:creator xml:lang="en">Adawiah, Adawiah</dc:creator>
	<dc:subject xml:lang="en">Etlingera elatior</dc:subject>
	<dc:subject xml:lang="en">cytotoxic</dc:subject>
	<dc:subject xml:lang="en">P-388 leukemia murine cell</dc:subject>
	<dc:subject xml:lang="en">BSLT</dc:subject>
	<dc:description xml:lang="en">The research characterization of cytotoxic fraction against P-388 leukemia murine cells from the extract honje (Etlingera elatior) seed have been reported. This research lead to isolated and characterization of cytotoxic compounds against P-388 leukemia murine cells from the extract E. elantior seed. The extract of E. elantior seed was maserated by methanol, n-hexane, and ethyl acetate, respectively and estimated their cytotoxic activity against P-388 leukemia murine cell with 3- (4, 5-dimetiltiazol-2-yl) -2,5-difeniltetrazolium bromide (MTT) assay guided toxicity test against of shrimp Artemia salina Leach. Brine shirmp Lethality Test (BSLT) method. The active extracts will be separated by fractionation using column chromatography, radial chromatography, and for analyzing the purity of isolate will estimate by HPLC. The chemical structure of pure isolate will be identified by spectroscopies data UV Vis, FTIR, NMR and MS. The ethyl acetate extract from honje seed have cytotoxic activity by leukemia P-388 cell  with IC50 19.21 µg/mL. The compound toxic as cytotoxicagainst P-388 leukemia murine cells is flavonoid compouds their is resveratrol, lapachol, apigenin, methylated chrysin, 6,2’-dihydroxyflavanone, 3-hydroxy-3,4’-dymethoxyflavone and 4’-hydroxy-5,7-dimethoxyflavanone.DOI: http://dx.doi.org/10.15408/jkv.v0i0.3640</dc:description>
	<dc:publisher xml:lang="en">Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University</dc:publisher>
	<dc:date>2017-05-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinjkt.ac.id/index.php/valensi/article/view/3640</dc:identifier>
	<dc:identifier>10.15408/jkv.v3i1.3640</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kimia Valensi; Jurnal Kimia VALENSI Volume 3, No. 1, Mei 2017; 79-87</dc:source>
	<dc:source>2548-3013</dc:source>
	<dc:source>2460-6065</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/3640/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2019 Alfindah Rusanti, Dede Sukandar, Tarso Rudiana, Adawiah Adawiah</dc:rights>
</oai_dc:dc>