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Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines

VALENSI · Vol. ume No. 2 (2020) · hlm. 133–139

DOI
10.15408/jkv.v6i2.15976
ISSN
2548-3013, 2460-6065
Terbit
2020-12-01
Penerbit
Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University
Bahasa
eng

Abstrak

Three steroids, 3α-hydroxystigmast-5(6), 22-diene-7-one (1), stigmasterol (2) and 3-hydroxy-7β-methoxystigmast-5(6)-ene (3), were isolated from the stem bark of Dysoxylum nutans. The chemical structures were identified by spectroscopic data, which includes IR, 1D-NMR, 2D-NMR, and HR-TOFMS as well as by comparing previously reported spectral data. Compounds 1-3 were tested for cytotoxic effect against MCF-7 breast cancer cell lines and compound 1 showed the strongest cytotoxic activity with an IC50 value of 20.13 ± 0.06 μM.

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Nurlelasari NurlelasariPadjadjaran University39
Kindi FarabiPadjadjaran University37
Desi HarnetiPadjadjaran University34
Al Arofatus NainiPadjadjaran University29
Rani MaharaniPadjadjaran University28
Ace Tatang HidayatPadjadjaran University21
Mohamad Nurul AzmiUniversiti Sains Malaysia16
Darwati DarwatiPadjadjaran University15
Erina HilmayantiPadjadjaran University12
Tati HerlinaPadjadjaran University7
Ricson P. HutagaolUniversitas Nusa Bangsa7
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Hadi KuncoroMulawarman University6
Khalijah AwangUniversity of Malaya6
Risyandi AnwarUniversitas Muhammadiyah Semarang6
Sandra Amalia RiyadiPadjadjaran University6
Desi Harneti Putri HuspaPadjadjaran University6
Wahyu SafriansyahPadjadjaran University5
Euis JulaehaPadjadjaran University5
Tjandrawati MozefIndonesian Institute of Sciences5
Gian PrimahanaNational Research and Innovation Agency5
Akhmad DarmawanIndonesian Institute of Sciences5
Fajar Fauzi AbdullahPadjadjaran University4
Agus SafariPadjadjaran University4
Muhammad HanafiNational Research and Innovation Agency4
Aprilia Permata SariPadjadjaran University4
Ronny LesmanaPadjadjaran University3
Dudi RunadiPadjadjaran University3
Purnama PurnamaPadjadjaran University3
Raihan Fathurrahman HasbillaPadjadjaran University2
Susianti SusiantiPadjadjaran University2
Sari PurbayaUniversitas Jenderal Achmad Yani2

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.uinjkt.ac.id/index.php/valensi/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines</dc:title>
	<dc:creator xml:lang="en">Mayanti, Tri</dc:creator>
	<dc:creator xml:lang="en">Amir, Nur Insani</dc:creator>
	<dc:creator xml:lang="en">Katja, Dewa Gede</dc:creator>
	<dc:creator xml:lang="en">Fajriah, Sofa</dc:creator>
	<dc:creator xml:lang="en">Darmawan, Ahmad</dc:creator>
	<dc:creator xml:lang="en">Supratman, Unang</dc:creator>
	<dc:creator xml:lang="en">Awang, Khlaijah</dc:creator>
	<dc:creator xml:lang="en">Shiono, Yoshihito</dc:creator>
	<dc:subject xml:lang="en">cytotoxic activity</dc:subject>
	<dc:subject xml:lang="en">Dysoxylum nutans</dc:subject>
	<dc:subject xml:lang="en">MCF-7 breast cancer cells</dc:subject>
	<dc:subject xml:lang="en">Meliaceae</dc:subject>
	<dc:subject xml:lang="en">stigmastane-type steroids</dc:subject>
	<dc:description xml:lang="en">Three steroids, 3α-hydroxystigmast-5(6), 22-diene-7-one (1), stigmasterol (2) and 3-hydroxy-7β-methoxystigmast-5(6)-ene (3), were isolated from the stem bark of Dysoxylum nutans. The chemical structures were identified by spectroscopic data, which includes IR, 1D-NMR, 2D-NMR, and HR-TOFMS as well as by comparing previously reported spectral data. Compounds 1-3 were tested for cytotoxic effect against MCF-7 breast cancer cell lines and compound 1 showed the strongest cytotoxic activity with an IC50 value of 20.13 ± 0.06 μM.</dc:description>
	<dc:publisher xml:lang="en">Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University</dc:publisher>
	<dc:date>2020-12-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinjkt.ac.id/index.php/valensi/article/view/15976</dc:identifier>
	<dc:identifier>10.15408/jkv.v6i2.15976</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kimia Valensi; Jurnal Kimia VALENSI Volume 6, No. 2, November 2020; 133-139</dc:source>
	<dc:source>2548-3013</dc:source>
	<dc:source>2460-6065</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/15976/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2020 Tri Mayanti</dc:rights>
</oai_dc:dc>