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Lignan (+)-Piperitol-γ,γ-Dimethylallylether from Stem Bark of Zanthoxylum rhetsa (Roxb.) DC (Rutaceae)

VALENSI · Vol. ume No. 2 (2022) · hlm. 171–177

DOI
10.15408/jkv.v8i2.26964
ISSN
2548-3013, 2460-6065
Terbit
2022-11-15
Penerbit
Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University
Bahasa
eng

Abstrak

Lignans are a group of phenylpropanoid dimers in which the phenylpropane units are linked by their propyl side chains' central carbon (C8). Lignans have various biological activities, including antiviral, anticancer, cancer preventive, and cytotoxic. Zanthoxylum rhetsa (Roxb.) DC is a tree with prickly branchlets belonging to the Zanthoxylum genus, commonly known as panggal buaya in Indonesia. Asian tribes have used this plant as traditional medicine. In this study, (+)-piperitol-γ,γ-dimethylallylether, a furofuran lignan, was successfully isolated. The chemical structure of compound 1 was determined based on spectroscopic data, including 1D- and 2D-NMR, mass spectroscopy, and by comparing with previous spectral data. In addition, compound 1 was tested for its cytotoxic activity against MCF-7 breast cancer cell lines in vitro and showed weak activity with the IC50 value of 261.37 µg/mL.

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Rekan penulisOrganisasiArtikel bersama
Kindi FarabiPadjadjaran University26
Nurlelasari NurlelasariPadjadjaran University22
Tri MayantiPadjadjaran University22
Desi HarnetiPadjadjaran University21
Sofa FajriahNational Research and Innovation Agency18
Rani MaharaniPadjadjaran University15
Yoshihito ShionoYamagata University13
Ace Tatang HidayatPadjadjaran University12
Mohamad Nurul AzmiUniversiti Sains Malaysia9
Darwati DarwatiPadjadjaran University8
Euis JulaehaPadjadjaran University6
Fajar Fauzi AbdullahPadjadjaran University6
Dewa Gede KatjaSam Ratulangi University5
Erina HilmayantiPadjadjaran University5
Risyandi AnwarUniversitas Muhammadiyah Semarang5
Harizon HarizonUniversitas Jambi5
Sandra Amalia RiyadiPadjadjaran University5
Wahyu SafriansyahPadjadjaran University4
Hadi KuncoroMulawarman University4
Khalijah AwangUniversity of Malaya3
Desi Harneti Putri HuspaPadjadjaran University3
Riza AprianiUniversitas Garut3
Shabarni GaffarPadjadjaran University3
Ronny LesmanaPadjadjaran University3
Sari PurbayaUniversitas Jenderal Achmad Yani3
Fera KurniadewiState University of Jakarta2
Ade DanovaBandung Institute of Technology2
Elvira HermawatiBandung Institute of Technology2
Warinthorn ChavasiriChulalongkorn University2
Raihan Fathurrahman HasbillaPadjadjaran University2
Susianti SusiantiPadjadjaran University2
Agus SafariPadjadjaran University2
Ricson P. HutagaolUniversitas Nusa Bangsa2
Muhammad HanafiNational Research and Innovation Agency2
Asri Peni WulandariPadjadjaran University2

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.uinjkt.ac.id/index.php/valensi/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Lignan (+)-Piperitol-γ,γ-Dimethylallylether from Stem Bark of Zanthoxylum rhetsa (Roxb.) DC (Rutaceae)</dc:title>
	<dc:creator xml:lang="en">Ruchiyat, Ruchiyat</dc:creator>
	<dc:creator xml:lang="en">Naini, Al Arofatus</dc:creator>
	<dc:creator xml:lang="en">Herlina, Tati</dc:creator>
	<dc:creator xml:lang="en">Musthapa, Iqbal</dc:creator>
	<dc:creator xml:lang="en">Supratman, Unang</dc:creator>
	<dc:subject xml:lang="en">Furofuran lignan</dc:subject>
	<dc:subject xml:lang="en">MCF-7</dc:subject>
	<dc:subject xml:lang="en">( ) piperitol-γ</dc:subject>
	<dc:subject xml:lang="en">γ-dimethylallylether</dc:subject>
	<dc:subject xml:lang="en">Rutaceae</dc:subject>
	<dc:subject xml:lang="en">Zanthoxylum rhetsa</dc:subject>
	<dc:subject xml:lang="en">( ) piperitol-γ</dc:subject>
	<dc:description xml:lang="en">Lignans are a group of phenylpropanoid dimers in which the phenylpropane units are linked by their propyl side chains' central carbon (C8). Lignans have various biological activities, including antiviral, anticancer, cancer preventive, and cytotoxic. Zanthoxylum rhetsa (Roxb.) DC is a tree with prickly branchlets belonging to the Zanthoxylum genus, commonly known as panggal buaya in Indonesia. Asian tribes have used this plant as traditional medicine. In this study, (+)-piperitol-γ,γ-dimethylallylether, a furofuran lignan, was successfully isolated. The chemical structure of compound 1 was determined based on spectroscopic data, including 1D- and 2D-NMR, mass spectroscopy, and by comparing with previous spectral data. In addition, compound 1 was tested for its cytotoxic activity against MCF-7 breast cancer cell lines in vitro and showed weak activity with the IC50 value of 261.37 µg/mL.</dc:description>
	<dc:publisher xml:lang="en">Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University</dc:publisher>
	<dc:date>2022-11-15</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinjkt.ac.id/index.php/valensi/article/view/26964</dc:identifier>
	<dc:identifier>10.15408/jkv.v8i2.26964</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kimia Valensi; Jurnal Kimia VALENSI Volume 8, No. 2, November 2022; 171-177</dc:source>
	<dc:source>2548-3013</dc:source>
	<dc:source>2460-6065</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/26964/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2022 Unang Supratman</dc:rights>
</oai_dc:dc>