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Nimonol from Chisocheton macrophyllus (Meliaceae) Seeds and Their Cytotoxic Activity against P-388 Leukaemia Cells

VALENSI · Vol. ume No. 2 (2022) · hlm. 263–268

DOI
10.15408/jkv.v8i2.27782
ISSN
2548-3013, 2460-6065
Terbit
2022-11-29
Penerbit
Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University
Bahasa
eng

Abstrak

The Chisocheton genus belongs to the Meliaceae family which produces various structures and activities of compounds, such as antimalarial, antimicrobial, antitumor, anti-inflammatory, and cytotoxic. This plant has 53 species that are spread in tropical and sub-tropical forests, including Indonesia. Chisocheton plants have been known as plants that produce limonoids, namely triterpenoid compounds that have been modified to lose four terminal carbons (tetranortriterpenoids). One of the species whose phytochemical reports are still few and interesting for research on limonoid content is Chisocheton macrophyllus. Chisocheton macrophyllus is a tall plant that grows in the rainforest in the northern part of the island of Sulawesi, Indonesia, has the regional name ma aa, gula, pasak lingga, gending, ta suea, bekak, or pithraj tree. This paper will describe a limonoid compound, namely nimonol which has been isolated from Chisocheton macrophyllus. Nimonol is known to have the molecular formula C28H36O5 from a group of havanensin. The structure was determined by spectroscopic methods UV, IR, 1D-NMR (1H-NMR, 13C-NMR, and DEPT), 2D-NMR (1H-1H COSY, HMQC, and HMBC), and mass spectroscopy.

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.uinjkt.ac.id/index.php/valensi/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Nimonol from Chisocheton macrophyllus (Meliaceae) Seeds and Their Cytotoxic Activity against P-388 Leukaemia Cells</dc:title>
	<dc:creator xml:lang="en">Nurlelasari, Nurlelasari</dc:creator>
	<dc:creator xml:lang="en">Huspa, Desi Harneti P.</dc:creator>
	<dc:creator xml:lang="en">Maharani, Rani</dc:creator>
	<dc:creator xml:lang="en">Darwati, Darwati</dc:creator>
	<dc:creator xml:lang="en">Mayanti, Tri</dc:creator>
	<dc:creator xml:lang="en">Farabi, Kindi</dc:creator>
	<dc:creator xml:lang="en">Hanafi, Muhammad</dc:creator>
	<dc:creator xml:lang="en">Supratman, Unang</dc:creator>
	<dc:subject xml:lang="en">C. macrophyllus</dc:subject>
	<dc:subject xml:lang="en">havanensin</dc:subject>
	<dc:subject xml:lang="en">limonoid</dc:subject>
	<dc:subject xml:lang="en">Meliaceae</dc:subject>
	<dc:description xml:lang="en">The Chisocheton genus belongs to the Meliaceae family which produces various structures and activities of compounds, such as antimalarial, antimicrobial, antitumor, anti-inflammatory, and cytotoxic. This plant has 53 species that are spread in tropical and sub-tropical forests, including Indonesia. Chisocheton plants have been known as plants that produce limonoids, namely triterpenoid compounds that have been modified to lose four terminal carbons (tetranortriterpenoids). One of the species whose phytochemical reports are still few and interesting for research on limonoid content is Chisocheton macrophyllus. Chisocheton macrophyllus is a tall plant that grows in the rainforest in the northern part of the island of Sulawesi, Indonesia, has the regional name ma aa, gula, pasak lingga, gending, ta suea, bekak, or pithraj tree. This paper will describe a limonoid compound, namely nimonol which has been isolated from Chisocheton macrophyllus. Nimonol is known to have the molecular formula C28H36O5 from a group of havanensin. The structure was determined by spectroscopic methods UV, IR, 1D-NMR (1H-NMR, 13C-NMR, and DEPT), 2D-NMR (1H-1H COSY, HMQC, and HMBC), and mass spectroscopy.</dc:description>
	<dc:publisher xml:lang="en">Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University</dc:publisher>
	<dc:date>2022-11-29</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:identifier>https://journal.uinjkt.ac.id/index.php/valensi/article/view/27782</dc:identifier>
	<dc:identifier>10.15408/jkv.v8i2.27782</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kimia Valensi; Jurnal Kimia VALENSI Volume 8, No. 2, November 2022; 263-268</dc:source>
	<dc:source>2548-3013</dc:source>
	<dc:source>2460-6065</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/27782/pdf</dc:relation>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/27782/16930</dc:relation>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/27782/17005</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2022 Nurlelasari . Nurlelasari, Desi Harneti P.H, Rani . Maharani, Darwati . ., Tri . Mayanti, Kindi . Farabi, Muhammad . Hanafi, Unang . Supratman</dc:rights>
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