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Sesquiterpenoids from the stem bark of Aglaia pachyphylla Miq (Meliaceae) and cytotoxic activity against MCF-7 Cancer Cell Line

VALENSI · Vol. ume No. 2 (2023) · hlm. 300–305

DOI
10.15408/jkv.v9i2.32782
ISSN
2548-3013, 2460-6065
Terbit
2023-12-28
Penerbit
Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University
Bahasa
eng

Abstrak

Sesquiterpenoids are terpenoid-derived compounds formed from three isoprene units with diverse pharmacological activities. Sesquiterpenoids can be obtained from higher plants, such as the genus Aglaia from the Meliaceae family. This study aims to isolate and characterize the structure of sesquiterpenoidsfrom the n-hexane extract of Aglaia pachyphylla Miq stem bark and to determine their cytotoxic activity against MCF-7 breast cancer cells. The n-hexane extract was separated and purified by various chromatography techniques such as vacuum liquid chromatography, normal-phase chromatography, and reversed-phase chromatography to obtain three sesquiterpenoids. The chemical structures of sesquiterpenoids were identified by various spectroscopic analyses such as IR, MS, 1D-NMR, and 2D-NMR and compared with previously reported spectrum data. Three sesquiterpenoids were identified as β-caryophyllene oxide (1), 1β-Hydroxy-4(15),5-eudesmadiene (2), and spathulenol (3). The three compounds were tested against MCF-7 breast cancer cells using the PrestoBlue method. Compound 2 showed the highest cytotoxic activity with an IC50 value of 262,25 µM.

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Tri MayantiPadjadjaran University52
Sofa FajriahNational Research and Innovation Agency37
Al Arofatus NainiPadjadjaran University37
Yoshihito ShionoYamagata University34
Ace Tatang HidayatPadjadjaran University32
Darwati DarwatiPadjadjaran University26
Erina HilmayantiPadjadjaran University14
Tati HerlinaPadjadjaran University11
Dewa Gede KatjaSam Ratulangi University11
Desi Harneti Putri HuspaPadjadjaran University10
Euis JulaehaPadjadjaran University9
Risyandi AnwarUniversitas Muhammadiyah Semarang9
Muhammad HanafiNational Research and Innovation Agency9
Mohamad Azlan NafiahSultan Idris Education University9
Ferry Ferdiansyah SofianPadjadjaran University9
Khalijah AwangUniversity of Malaya8
Agus SafariPadjadjaran University7
Sandra Amalia RiyadiPadjadjaran University5
Ronny LesmanaPadjadjaran University5
Aprilia Permata SariPadjadjaran University5
Febbry RomundzaUniversitas Jambi4
Raihan Fathurrahman HasbillaPadjadjaran University4
Susianti SusiantiPadjadjaran University4
Ricson P. HutagaolUniversitas Nusa Bangsa4
Sari PurbayaUniversitas Jenderal Achmad Yani3
Rurini RetnowatiUniversity of Brawijaya3
Arif Rahman HakimPadjadjaran University3
Aulia SanovaUniversitas Jambi2
Haryanto HaryantoUniversitas Jambi2

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.uinjkt.ac.id/index.php/valensi/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Sesquiterpenoids from the stem bark of Aglaia pachyphylla Miq (Meliaceae) and cytotoxic activity against MCF-7 Cancer Cell Line</dc:title>
	<dc:creator xml:lang="en">Safriansyah, Wahyu</dc:creator>
	<dc:creator xml:lang="en">Abdullah, Fajar Fauzi</dc:creator>
	<dc:creator xml:lang="en">Juliansyah, Endang</dc:creator>
	<dc:creator xml:lang="en">Farabi, Kindi</dc:creator>
	<dc:creator xml:lang="en">Harizon, Harizon</dc:creator>
	<dc:creator xml:lang="en">Kuncoro, Hadi</dc:creator>
	<dc:creator xml:lang="en">Nurlelasari, Nurlelasari</dc:creator>
	<dc:creator xml:lang="en">Maharani, Rani</dc:creator>
	<dc:creator xml:lang="en">Taib, Mohamad Nurul Azmi Mohamad</dc:creator>
	<dc:creator xml:lang="en">Supratman, Unang</dc:creator>
	<dc:creator xml:lang="en">Harneti, Desi</dc:creator>
	<dc:subject xml:lang="en">Aglaia pachyphylla</dc:subject>
	<dc:subject xml:lang="en">sesquiterpenoid</dc:subject>
	<dc:subject xml:lang="en">MCF-7</dc:subject>
	<dc:subject xml:lang="en">cytotoxic activity</dc:subject>
	<dc:description xml:lang="en">Sesquiterpenoids are terpenoid-derived compounds formed from three isoprene units with diverse pharmacological activities. Sesquiterpenoids can be obtained from higher plants, such as the genus Aglaia from the Meliaceae family. This study aims to isolate and characterize the structure of sesquiterpenoidsfrom the n-hexane extract of Aglaia pachyphylla Miq stem bark and to determine their cytotoxic activity against MCF-7 breast cancer cells. The n-hexane extract was separated and purified by various chromatography techniques such as vacuum liquid chromatography, normal-phase chromatography, and reversed-phase chromatography to obtain three sesquiterpenoids. The chemical structures of sesquiterpenoids were identified by various spectroscopic analyses such as IR, MS, 1D-NMR, and 2D-NMR and compared with previously reported spectrum data. Three sesquiterpenoids were identified as β-caryophyllene oxide (1), 1β-Hydroxy-4(15),5-eudesmadiene (2), and spathulenol (3). The three compounds were tested against MCF-7 breast cancer cells using the PrestoBlue method. Compound 2 showed the highest cytotoxic activity with an IC50 value of 262,25 µM.</dc:description>
	<dc:publisher xml:lang="en">Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University</dc:publisher>
	<dc:date>2023-12-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
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	<dc:identifier>https://journal.uinjkt.ac.id/index.php/valensi/article/view/32782</dc:identifier>
	<dc:identifier>10.15408/jkv.v9i2.32782</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kimia Valensi; Jurnal Kimia VALENSI Volume 9, No. 2, November 2023; 300-305</dc:source>
	<dc:source>2548-3013</dc:source>
	<dc:source>2460-6065</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/32782/pdf_1</dc:relation>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/32782/17206</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2023 Wahyu Safriansyah, Fajar Fauzi Abdullah, Endang Juliansyah, Kindi Farabi, Harizon Harizon, Hadi Kuncoro, Nurlelasari Nurlelasari, Rani Maharani, Mohamad Nurul Azmi Mohamad Taib, Unang Supratman, Desi Harneti</dc:rights>
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