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Tea Constituent in Protecting Glyphosate Effect on Human Breast Cancers Cells (MCF-7) Growth

VALENSI · Vol. ume No. 2 (2023) · hlm. 271–279

DOI
10.15408/jkv.v9i2.33229
ISSN
2548-3013, 2460-6065
Terbit
2023-12-22
Penerbit
Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University
Bahasa
eng

Abstrak

Glyphosate, which has been documented as a contaminant in tea, promotes the proliferation of human breast cancer cells (MCF-7). Tea, on the other hand, includes various antioxidants, including epigallocatechin gallate (EGCG), which may protect against cancer cell proliferation. The purpose of this research is to determine the preventive effect of concentrated brewed green tea on MCF-7 development caused by glyphosate. The glyphosate concentration that promotes MCF-7 development was determined using a serial concentration of glyphosate. Glyphosate concentrations of up to 64 mg/L were shown to have no effect on MCF-7 cell proliferation. Concentrated brewed tea and EGCG 200 mg/L have the potential to suppress MCF-7 cell proliferation in the presence of glyphosate up to 512 mg/L. The combination of glyphosate and concentrated brewed tea or EGCG protects against glyphosate toxicity via altering the expression of tumor suppressor protein (p53).

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  • IPB University
  • National Research and Innovation Agency
  • Indonesian Oil Palm Research Institute
  • University of Hawaiʻi at Mānoa
  • Syarif Hidayatullah State Islamic University Jakarta
  • Nara Institute of Science and Technology
  • Bandung Institute of Technology
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Rekan penulisOrganisasiArtikel bersama
Setyanto Tri WahyudiIPB University3
Utami Dyah SyafitriIPB University2
Nampiah SukarnoIPB University2
Latifah Kosim DarusmanIPB University2
Mashuri WaiteUniversity of Hawaiʻi at Mānoa2
. YulianaAfiliasi tidak diketahui2
Huda Shalahudin DarusmanIPB University2
Muhammad Eka PrastyaNational Research and Innovation Agency2
Shadila Fira AsokaIPB University2
Raendi RayendraSyarif Hidayatullah State Islamic University Jakarta2
Fikry AwaluddinIPB University2
Bambang Pontjo PriosoeryantoIPB University2
Eka Winarni SapitriIPB University1
I Nyoman Pugeg AryanthaBandung Institute of Technology1
Utut WidyastutiIPB University1
Rohani Cinta Badia GintingIPB University1
Sihegiko KanayaNara Institute of Science and Technology1
Sintho Wahyuning ArdieIPB University1
Soekisman TjitrosoedirdjoSoutheast Asian Regional Centre for Tropical Biology1
Za’aziza Ridha JuliaIPB University1
Irma Herawati SupartoIPB University1
Uus SaepulohIPB University1
Rizki Aulia AnsariIPB University1
Rachmitasari NovianaIPB University1
Sri ListiyowatiIPB University1
Rika Indri AstutiIPB University1
Nadila Fany AshafaniIPB University1
Vera PermatasariNational Research and Innovation Agency1
Dwi RetnowatiAfiliasi tidak diketahui1
Tjandrawati MozefIndonesian Institute of Sciences1
Indri YatiNational Research and Innovation Agency1
Erma SuryantiSumatera Institute of Technology1
Novita ArianiNational Research and Innovation Agency1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.uinjkt.ac.id/index.php/valensi/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Tea Constituent in Protecting Glyphosate Effect on Human Breast Cancers Cells (MCF-7) Growth</dc:title>
	<dc:creator xml:lang="en">Batubara, Irmanida</dc:creator>
	<dc:creator xml:lang="en">Suprihatini, Rohayati</dc:creator>
	<dc:creator xml:lang="en">Mariya, Silmi</dc:creator>
	<dc:creator xml:lang="en">Achmadi, Suminar Setiati</dc:creator>
	<dc:creator xml:lang="en">Sokoastri, Valentina</dc:creator>
	<dc:creator xml:lang="en">Mulyatni, Agustin Sri</dc:creator>
	<dc:creator xml:lang="en">Hakim, Arif Rakhman</dc:creator>
	<dc:subject xml:lang="en">glyphosate</dc:subject>
	<dc:subject xml:lang="en">EGCG</dc:subject>
	<dc:subject xml:lang="en">tea</dc:subject>
	<dc:subject xml:lang="en">human breast cancer cell</dc:subject>
	<dc:subject xml:lang="en">p53</dc:subject>
	<dc:description xml:lang="en">Glyphosate, which has been documented as a contaminant in tea, promotes the proliferation of human breast cancer cells (MCF-7). Tea, on the other hand, includes various antioxidants, including epigallocatechin gallate (EGCG), which may protect against cancer cell proliferation. The purpose of this research is to determine the preventive effect of concentrated brewed green tea on MCF-7 development caused by glyphosate. The glyphosate concentration that promotes MCF-7 development was determined using a serial concentration of glyphosate. Glyphosate concentrations of up to 64 mg/L were shown to have no effect on MCF-7 cell proliferation. Concentrated brewed tea and EGCG 200 mg/L have the potential to suppress MCF-7 cell proliferation in the presence of glyphosate up to 512 mg/L. The combination of glyphosate and concentrated brewed tea or EGCG protects against glyphosate toxicity via altering the expression of tumor suppressor protein (p53).</dc:description>
	<dc:publisher xml:lang="en">Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University</dc:publisher>
	<dc:date>2023-12-22</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinjkt.ac.id/index.php/valensi/article/view/33229</dc:identifier>
	<dc:identifier>10.15408/jkv.v9i2.33229</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kimia Valensi; Jurnal Kimia VALENSI Volume 9, No. 2, November 2023; 271-279</dc:source>
	<dc:source>2548-3013</dc:source>
	<dc:source>2460-6065</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/33229/pdf_1</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2023 Irmanida Batubara, Rohayati Suprihatini, Silmi Mariya, Suminar Setiati Achmadi, Valentina Sokoastri, Agustin Sri Mulyatni, Arif Rakhman Hakim</dc:rights>
</oai_dc:dc>