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Modified Bacterial Cellulose-Based Composite Profile for Drug Release of Tetracycline Hydrochloride

VALENSI · Vol. ume No. 1 (2024) · hlm. 76–85

DOI
10.15408/jkv.v10i1.37663
ISSN
2548-3013, 2460-6065
Terbit
2024-06-09
Penerbit
Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University
Bahasa
eng

Abstrak

Bacterial cellulose (BC) is a biodegradable natural polymer with high mechanical strength and non-toxicity. This biopolymer is widely used as a candidate in biomedical fields, such as drug delivery, wound healing, and filtration systems. However, BC lacks antibacterial activity which limits its use in biomedical applications. So, modification of BC-based composite is required. This study aims to examine the effects of modifying BC-based composites with fillers such as graphite (G) and polyvinyl alcohol (PVA) on the release of tetracycline hydrochloride (TCH) drugs. Adding fillers to BC can alter its physical and mechanical properties, reducing its porosity and swelling rate in acidic and alkaline mediums. The drug release of TCH from modified BC-based composites follows the Korsmeyer-Peppas and Hixson-Crowell kinetics models. Adding filler and TCH antibiotic to the composite enhances its antibacterial activity against Staphylococcus aureus with a significant inhibition zone. The results of the inhibition zone show that composites have the potential to be applied in biomedical fields, especially in transdermal patches.

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21 penulis · 58 tautan kepenulisan bersama · 30 lintas organisasi

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  • University of Mataram
  • National Research and Innovation Agency
  • Trường Đại học Kỹ thuật - Công nghệ Cần Thơ
  • Suranaree University of Technology
  • Indonesian Institute of Sciences
  • Sunan Gunung Djati State Islamic University Bandung
  • The University of Osaka
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  • Organisasi sama
  • Afiliasi tidak diketahui
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Rekan penulisOrganisasiArtikel bersama
Saprizal HadisaputraUniversity of Mataram3
Jufrizal SyahriUniversitas Muhammadiyah Riau3
Maria UlfaMuhammadiyah University of Yogyakarta3
I Gede Adhitya Wisnu WardhanaUniversity of Mataram1
Sarwa HitaUniversity of Mataram1
Nguyen Dang Hoa NghiemTrường Đại học Kỹ thuật - Công nghệ Cần Thơ1
Hendry Sakke TiraUniversity of Mataram1
Made WirawanUniversity of Mataram1
Samsul RahmanUniversity of Mataram1
Ekarong SukjitSuranaree University of Technology1
Rike YudiantiNational Research and Innovation Agency1
Yuyun IrmawatiIndonesian Institute of Sciences1
Shofia ManzaliniSunan Gunung Djati State Islamic University Bandung1
Bambang SugengNational Research and Innovation Agency1
Harayasu AsaharaThe University of Osaka1

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.uinjkt.ac.id/index.php/valensi/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Modified Bacterial Cellulose-Based Composite Profile for Drug Release of Tetracycline Hydrochloride</dc:title>
	<dc:creator xml:lang="en">Cahyani, Ni Wayan Chyntia Pramesti</dc:creator>
	<dc:creator xml:lang="en">Yuanita, Emmy</dc:creator>
	<dc:creator xml:lang="en">Dharmayani, Ni Komang Tri</dc:creator>
	<dc:creator xml:lang="en">Sudirman, Sudirman</dc:creator>
	<dc:creator xml:lang="en">Sudewianingsih, Ni Made</dc:creator>
	<dc:creator xml:lang="en">Ulfa, Maria</dc:creator>
	<dc:subject xml:lang="en">Bacterial cellulose</dc:subject>
	<dc:subject xml:lang="en">graphite</dc:subject>
	<dc:subject xml:lang="en">drug release</dc:subject>
	<dc:subject xml:lang="en">polyvinyl alcohol</dc:subject>
	<dc:subject xml:lang="en">tetracycline hydrochloride</dc:subject>
	<dc:description xml:lang="en">Bacterial cellulose (BC) is a biodegradable natural polymer with high mechanical strength and non-toxicity. This biopolymer is widely used as a candidate in biomedical fields, such as drug delivery, wound healing, and filtration systems. However, BC lacks antibacterial activity which limits its use in biomedical applications. So, modification of BC-based composite is required. This study aims to examine the effects of modifying BC-based composites with fillers such as graphite (G) and polyvinyl alcohol (PVA) on the release of tetracycline hydrochloride (TCH) drugs. Adding fillers to BC can alter its physical and mechanical properties, reducing its porosity and swelling rate in acidic and alkaline mediums. The drug release of TCH from modified BC-based composites follows the Korsmeyer-Peppas and Hixson-Crowell kinetics models. Adding filler and TCH antibiotic to the composite enhances its antibacterial activity against Staphylococcus aureus with a significant inhibition zone. The results of the inhibition zone show that composites have the potential to be applied in biomedical fields, especially in transdermal patches.</dc:description>
	<dc:publisher xml:lang="en">Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University</dc:publisher>
	<dc:date>2024-06-09</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:format>image/jpeg</dc:format>
	<dc:identifier>https://journal.uinjkt.ac.id/index.php/valensi/article/view/37663</dc:identifier>
	<dc:identifier>10.15408/jkv.v10i1.37663</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kimia Valensi; Jurnal Kimia VALENSI,  Volume 10, No. 1, May 2024; 76-85</dc:source>
	<dc:source>2548-3013</dc:source>
	<dc:source>2460-6065</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/37663/pdf</dc:relation>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/37663/17369</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Ni Wayan Chyntia Pramesti Cahyani Pramesti Cahyan, Emmy Yuanita, Ni Komang Tri Dharmayani, Sudirman Sudirman, Ni Made Sudewianingsih, Maria Ulfa</dc:rights>
</oai_dc:dc>