Akses terbuka Jurnal SINTA 1
Microwave-Assisted Method for Synthesizing UV-Protective Methoxy-Benzylidene Cyclohexanone Derivatives Using Green Solvents
VALENSI · Vol. ume No. 1 (2026) · hlm. 97–109
- ISSN
- 2548-3013, 2460-6065
- Terbit
- 2026-05-31
- Penerbit
- Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University
- Bahasa
- eng
Abstrak
Benzylidene cyclohexanone derivatives are known for their significant biological activities; however, traditional synthesis methods often involve non-eco-friendly processes and solvents. This research aims to identify the optimal solvent for maximum yield and to evaluate the UV-protection activity. The synthesis was conducted through a Claisen-Schmidt condensation reaction under NaOH catalysis with microwave irradiation for 60 seconds. Solvents tested included H2O, H2O/MeOH (1:1 v/v), H2O/EtOH (1:1 v/v), MeOH, and EtOH. Reaction purity was assessed using TLC scanning. The product with the highest purity was recrystallized from EtOH and characterized by melting point, UV-Vis, FT-IR, ¹H-NMR, and GC-MS analysis. The UV-protection activity was evaluated in vitro. The results indicate the successful synthesis of two benzylidene cyclohexanone derivatives: (2E,6E)-bis(4-methoxybenzylidene) cyclohexanone (yellow needles) and (E)-2-(4-methoxybenzylidene) cyclohexanone (orange). The H2O/MeOH (1:1 v/v) solvent provided the highest yields of 58.49% and 62.71%, respectively. The (2E,6E)-bis(4-methoxybenzylidene) cyclohexanone demonstrated a high SPF value of 9.908, offering maximum protection at 50 ppm concentration, while the mixed compound, (E)-2-(4-methoxybenzylidene) cyclohexanone, achieved an SPF of 15.324, categorized as ultra protection.
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- State University of Semarang
- University of Brawijaya
- Universitas Airlangga
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Tampilkan sebagai tabel
| Rekan penulis | Organisasi | Artikel bersama |
|---|---|---|
| Mohamad Syaefudin | State University of Semarang | 2 |
| Mohamad Syaefudin | State University of Semarang | 2 |
| Sudarwoto Sudarwoto | State University of Semarang | 2 |
| Diah Vitri Widayanti | State University of Semarang | 2 |
| Neli Purwani | State University of Semarang | 2 |
| Ani Budi Astuti | University of Brawijaya | 1 |
| Suci Astutik | University of Brawijaya | 1 |
| Nur Silviyah Rahmi | University of Brawijaya | 1 |
| Alifiandi Rafi Muhammad | University of Brawijaya | 1 |
| Ulfah Maisaroh | University of Brawijaya | 1 |
| Kismi Mubarokah | Afiliasi tidak diketahui | 1 |
| Harianingsih Harianingsih | Afiliasi tidak diketahui | 1 |
| Maharani Kusumaningrum | Afiliasi tidak diketahui | 1 |
| Vera Noviana Sulistyawan | Afiliasi tidak diketahui | 1 |
| Savira Rinda Erliana | Afiliasi tidak diketahui | 1 |
| Isnina Noor Ubay | Afiliasi tidak diketahui | 1 |
| Indra Sakti Pangestu | Afiliasi tidak diketahui | 1 |
| Taffitia Risnanti Yusuf | State University of Semarang | 1 |
| Miftah Fatimah | Afiliasi tidak diketahui | 1 |
| Sudarwoto - | Afiliasi tidak diketahui | 1 |
| Kiki Novitasari | Afiliasi tidak diketahui | 1 |
| Dewi Wulandari | Universitas Airlangga | 1 |
| Dwi Astuti | State University of Semarang | 1 |
| Umi Mufidah | Afiliasi tidak diketahui | 1 |
| Yulia Tricahyaningtyas | State University of Semarang | 1 |
| Bening Pranesthi | State University of Semarang | 1 |
| Eka Ayu Susanti | State University of Semarang | 1 |
| Tri Eko Agustiningrum | Afiliasi tidak diketahui | 1 |
| Maulida Arum Sari | Afiliasi tidak diketahui | 1 |
| Nur Aini Muharramah | Afiliasi tidak diketahui | 1 |
| Dwi Astuti | State University of Semarang | 1 |
| Hidayah Hidayah | State University of Semarang | 1 |
| Jihan Ayu Safira | State University of Semarang | 1 |
| Putri Dwi Astuti | State University of Semarang | 1 |
| Durrotum Millatina | Afiliasi tidak diketahui | 1 |
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