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Eudesman-Type Sesquiterpenoids from Stem Bark Dysoxylum gaudichaudianum and Cytotoxic Evaluation Against Human HeLa Cervical Cancer

VALENSI · Vol. ume No. 2 (2025) · hlm. 200–207

DOI
10.15408/jkv.v11i2.46788
ISSN
2548-3013, 2460-6065
Terbit
2025-11-30
Penerbit
Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Two eudesmane-type sesquiterpenoids were isolated from the stem bark of Dysoxylum gaudichaudianum: 6α-hydroxy-eudesm-4(15)-en-1-one (1) and eudesm-4(15),7-dien-1β-ol (2). This study represents the first report of these compounds not only from D. gaudichaudianum but also from the genus Dysoxylum. The cytotoxic potential of two sesquiterpenoids was assessed against human cervical carcinoma (HeLa) cells employing the Resazurin-based PrestoBlue assay. Using cisplatin as a positive control, compound 1 exhibited moderate cytotoxicity with an IC₅₀ of 28.04 µM, whereas compound 2 showed comparatively weaker activity, with an IC₅₀ of 58.37 µM. Their structures were elucidated through comprehensive spectroscopic analyses, including HR-ESI-MS, ¹H NMR, and ¹³C NMR. Structure–activity relationship analysis indicates that hydroxylation at C-6 enhances cytotoxic activity, whereas the C-6/C-7 olefinic moiety reduces potency, likely due to increased molecular rigidity, highlighting key structural features for activity modulation in the eudesmane scaffold.

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Rekan penulisOrganisasiArtikel bersama
Nurlelasari NurlelasariPadjadjaran University48
Desi HarnetiPadjadjaran University42
Rani MaharaniPadjadjaran University35
Yoshihito ShionoYamagata University26
Ace Tatang HidayatPadjadjaran University22
Darwati DarwatiPadjadjaran University20
Mohamad Nurul AzmiUniversiti Sains Malaysia18
Erina HilmayantiPadjadjaran University12
Dewa Gede KatjaSam Ratulangi University11
Harizon HarizonUniversitas Jambi10
Tati HerlinaPadjadjaran University9
Hadi KuncoroMulawarman University9
Risyandi AnwarUniversitas Muhammadiyah Semarang9
Sandra Amalia RiyadiPadjadjaran University9
Ferry Ferdiansyah SofianPadjadjaran University9
Wahyu SafriansyahPadjadjaran University7
Euis JulaehaPadjadjaran University7
Fajar Fauzi AbdullahPadjadjaran University7
Desi Harneti Putri HuspaPadjadjaran University7
Muhammad HanafiNational Research and Innovation Agency6
Mohamad Azlan NafiahSultan Idris Education University6
Khalijah AwangUniversity of Malaya5
Ricson P. HutagaolUniversitas Nusa Bangsa5
Agus SafariPadjadjaran University5
Aprilia Permata SariPadjadjaran University5
Tjandrawati MozefIndonesian Institute of Sciences4
Gian PrimahanaNational Research and Innovation Agency4
Ronny LesmanaPadjadjaran University4
Raihan Fathurrahman HasbillaPadjadjaran University3
Susianti SusiantiPadjadjaran University3
Akhmad DarmawanIndonesian Institute of Sciences3
Sari PurbayaUniversitas Jenderal Achmad Yani2
Arif Rahman HakimPadjadjaran University2

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.uinjkt.ac.id/index.php/valensi/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Eudesman-Type Sesquiterpenoids from Stem Bark Dysoxylum gaudichaudianum and Cytotoxic Evaluation Against Human HeLa Cervical Cancer</dc:title>
	<dc:creator xml:lang="en">Maira, Faizah </dc:creator>
	<dc:creator xml:lang="en">Naini, Al Arofatus </dc:creator>
	<dc:creator xml:lang="en">Mayanti, Tri </dc:creator>
	<dc:creator xml:lang="en">Farabi, Kindi</dc:creator>
	<dc:creator xml:lang="en">Fajriah, Sofa</dc:creator>
	<dc:creator xml:lang="en">Retnowati, Rurini</dc:creator>
	<dc:creator xml:lang="en">Supratman, Unang</dc:creator>
	<dc:subject xml:lang="en">Dysoxylum gaudichaudianum</dc:subject>
	<dc:subject xml:lang="en">eudesmane-type sesquiterpenoids</dc:subject>
	<dc:subject xml:lang="en">hela cancer cell</dc:subject>
	<dc:subject xml:lang="en">Meliaceae</dc:subject>
	<dc:description xml:lang="en">Two eudesmane-type sesquiterpenoids were isolated from the stem bark of Dysoxylum gaudichaudianum: 6α-hydroxy-eudesm-4(15)-en-1-one (1) and eudesm-4(15),7-dien-1β-ol (2). This study represents the first report of these compounds not only from D. gaudichaudianum but also from the genus Dysoxylum. The cytotoxic potential of two sesquiterpenoids was assessed against human cervical carcinoma (HeLa) cells employing the Resazurin-based PrestoBlue assay. Using cisplatin as a positive control, compound 1 exhibited moderate cytotoxicity with an IC₅₀ of 28.04 µM, whereas compound 2 showed comparatively weaker activity, with an IC₅₀ of 58.37 µM. Their structures were elucidated through comprehensive spectroscopic analyses, including HR-ESI-MS, ¹H NMR, and ¹³C NMR. Structure–activity relationship analysis indicates that hydroxylation at C-6 enhances cytotoxic activity, whereas the C-6/C-7 olefinic moiety reduces potency, likely due to increased molecular rigidity, highlighting key structural features for activity modulation in the eudesmane scaffold.</dc:description>
	<dc:publisher xml:lang="en">Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University</dc:publisher>
	<dc:date>2025-11-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinjkt.ac.id/index.php/valensi/article/view/46788</dc:identifier>
	<dc:identifier>10.15408/jkv.v11i2.46788</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kimia Valensi; Jurnal Kimia VALENSI,  Volume 11, No. 2, November 2025; 200-207</dc:source>
	<dc:source>2548-3013</dc:source>
	<dc:source>2460-6065</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/46788/18424</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2025 Faizah  Maira, Al Arofatus  Naini, Tri  Mayanti, Kindi Farabi, Sofa Fajriah, Rurini Retnowati, Unang Supratman</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>