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α-Glucosidase Inhibitory Activity of Triglycerides and Methyl Linoleate of Murraya koenigii Spreng from Malaysia

VALENSI · Vol. ume No. 1 (2026) · hlm. 163–169

DOI
10.15408/jkv.v12i1.51030
ISSN
2548-3013, 2460-6065
Terbit
2026-06-10
Penerbit
Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

This study was designed to examine the α-glucosidase inhibitory activity of triglycerides and methyl linoleate isolated from the root extract of Murraya koenigii Spreng in Malaysia. Although M. koenigii has been widely reported for its medicinal properties, few studies have examined the α-glucosidase inhibitory activity of its isolated lipid compounds, particularly triglycerides and methyl linoleate. The chemical compounds were obtained by cold extraction with various solvents and purified by chromatographic techniques, including NMR, MS, and IR analyses. Antidiabetic activity was evaluated using an α-glucosidase inhibitory assay. The results of these studies indicated that triglyceride (1) (IC50 = 33.6 ± 0.05 µg/mL) from the hexane crude extract and methyl linoleate (2) (IC50 = 13.9 ± 0.19 µg/mL) from the methanol crude extract exhibited potent inhibitory activity in the α-glucosidase inhibitory assay. The results showed that root extracts of M. koenigii exhibit significant antidiabetic activity, which may help identify new chemical classes of natural antidiabetic substances.

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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.uinjkt.ac.id/index.php/valensi/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">α-Glucosidase Inhibitory Activity of Triglycerides and Methyl Linoleate of Murraya koenigii Spreng from Malaysia</dc:title>
	<dc:creator xml:lang="en">Ibrahım, Noor Hazlina </dc:creator>
	<dc:creator xml:lang="en">Nafiah, Mohd Azlan </dc:creator>
	<dc:creator xml:lang="en">Hasnan, Muhammad Hafiz Husna </dc:creator>
	<dc:creator xml:lang="en">Salam, Supriatno</dc:creator>
	<dc:creator xml:lang="en">Tan, Siow-Ping </dc:creator>
	<dc:creator xml:lang="en">Rudiana, Tarso</dc:creator>
	<dc:subject xml:lang="en">α-glucosidase inhibitory activity</dc:subject>
	<dc:subject xml:lang="en">antidiabetic activity</dc:subject>
	<dc:subject xml:lang="en">methyl linoleate</dc:subject>
	<dc:subject xml:lang="en">Murraya koenigii</dc:subject>
	<dc:subject xml:lang="en">triglycerides</dc:subject>
	<dc:description xml:lang="en">This study was designed to examine the α-glucosidase inhibitory activity of triglycerides and methyl linoleate isolated from the root extract of Murraya koenigii Spreng in Malaysia. Although M. koenigii has been widely reported for its medicinal properties, few studies have examined the α-glucosidase inhibitory activity of its isolated lipid compounds, particularly triglycerides and methyl linoleate. The chemical compounds were obtained by cold extraction with various solvents and purified by chromatographic techniques, including NMR, MS, and IR analyses. Antidiabetic activity was evaluated using an α-glucosidase inhibitory assay. The results of these studies indicated that triglyceride (1) (IC50 = 33.6 ± 0.05 µg/mL) from the hexane crude extract and methyl linoleate (2) (IC50 = 13.9 ± 0.19 µg/mL) from the methanol crude extract exhibited potent inhibitory activity in the α-glucosidase inhibitory assay. The results showed that root extracts of M. koenigii exhibit significant antidiabetic activity, which may help identify new chemical classes of natural antidiabetic substances.</dc:description>
	<dc:publisher xml:lang="en">Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University</dc:publisher>
	<dc:date>2026-06-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.uinjkt.ac.id/index.php/valensi/article/view/51030</dc:identifier>
	<dc:identifier>10.15408/jkv.v12i1.51030</dc:identifier>
	<dc:source xml:lang="en">Jurnal Kimia Valensi; Jurnal Kimia VALENSI,  Volume 12, No. 1, May 2026; 163-169</dc:source>
	<dc:source>2548-3013</dc:source>
	<dc:source>2460-6065</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.uinjkt.ac.id/index.php/valensi/article/view/51030/19309</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Noor Hazlina  Ibrahım, Mohd Azlan  Nafiah, Muhammad Hafiz Husna  Hasnan, Supriatno Salam, Siow-Ping  Tan, Tarso Rudiana</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>