Indoor air quality affects the human health conditions who are in the room, such as the emergence of a complaint Sick Building Syndrome (SBS). The term is used for health problems related to indoor air quality that can be caused by various factors such as physical, including biological chemistry in this case the air microbiology. This research aims to determine the indoor air quality in the administration room of Hasanuddin University Makassar. This study was an observational study design. This study uses 15 faculties and Rectorat building consisting of 21 rooms as sample points. The result of the research shows that there are 2 rooms with total number of germs above the threshold ( 700 Colonies / m3) with total germs of 897 and 769, respectively 9 with temperatures not qualified because they have room temperature at 18 ° C, 26 ° C and there are 8 rooms with room humidity not eligible for having 60% or 40% moisture. There are 7 rooms identified pathogens such as Staphylococcus aureus bacteria, Pseudomonas aeruginosa, Pseudomonas aeruginosa, P.aeruginosa, and candida sp
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