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Study of Physical Characteristic and Equivalence between Generic and Branded Name of Phenylbutazone Tablet

Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan · Vol. 3 No. 2 (2017)

DOI
10.33772/pharmauho.v3i2.3537
ISSN
2715-4181
Published
2017-09-16
Publisher
Fakultas Farmasi Universitas Halu Oleo
Language
eng

Abstract

Physical characterization and equivalence testing of generic and branded names of phenylbutazone tablets have been done. The information about quality of generic drugs is expected to increase the use of generic drugs by health practitioners and public. Dissolution test carried out by in vitro had correlation with bioequivalence by in vivo test. Sample of dissolution testing were generic (G) and branded (A and B) names of 200 mg phenylbutazone tablets. Physical characteristic test performed by uniformity weight test, hardness and disintegration time. Dissolution test were conducted by using basket and spectrophotometry ultra violet method in 200-400 nm wavelength. The result of uniformity weight of generic drug and branded drug was 352,02 mg and 352,82 mg, the hardness of generic was 9,58 kgf and branded was 9,50 kgf, and disintegration test result of generic was 16,1 minutes and branded was 3 minutes. The result of dissolution testing were dissolution profile and dissolved concentration at 30 minutes that compared to qualify of USP XXXII. Relative bioavailability testing of generic to A brand was 101.580 and generic to B brand was 105.275. Based on statistical test, there was no significant different or pharmaceutical equivalent. The generic tablets were equivalent to A and B branded names tablets with similar factors 82.120 and 74.271.Keywords: Equivalence, Dissolution, Salbutamol tablet; generic name, branded name

Collaboration network of the authors

40 authors · 153 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Rini HamsidiAffiliation unknown3
Fery Indradewi ArmadanyAffiliation unknown3
Suryani SuryaniUniversitas Halu Oleo2
Sunandar IhsanUniversitas Halu Oleo2
Muhammad Handoyo SahumenaUniversitas Halu Oleo2
Rifa'atul MahmudahAffiliation unknown2
H HalikAffiliation unknown2
R RamlahAffiliation unknown2
Nurramadhani Armada SidaUniversitas Halu Oleo1
Yamin YaminUniversitas Halu Oleo1
Arfan ArfanUniversitas Halu Oleo1
Ardiyanti ArdiyantiAffiliation unknown1
Nurhayani HMAffiliation unknown1
Muhammad Juharisman SaputraAffiliation unknown1
Wa BaaneAffiliation unknown1
Novi NoviAffiliation unknown1
Ayu Sasta FiyanaAffiliation unknown1
Wahyuni WahyuniAffiliation unknown1
Henny KasmawatiUniversitas Halu Oleo1
S SabarudinAffiliation unknown1
W WahyuniAffiliation unknown1
Muhammad Hajrul MalakaAffiliation unknown1
Aty WidyawaruyantiAffiliation unknown1
Achmad Fuad HafidAffiliation unknown1
Wiwied EkasariAffiliation unknown1
Ari SartinahUniversitas Halu Oleo1
Andi Nafisah Tendri AdjengAffiliation unknown1
Muhammad ArbaAffiliation unknown1
Y YaminAffiliation unknown1
N NurhasanaAffiliation unknown1
Asniar PascayantriAffiliation unknown1
Wa FiaAffiliation unknown1
Sitti AdawiaAffiliation unknown1
N NovitasariAffiliation unknown1
R RahmasariAffiliation unknown1
Dhidi Dharmadi HasanuddinAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/pharmauho/oai, first harvested 30 Okt 2026, last seen 30 Okt 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Study of Physical Characteristic and Equivalence between Generic and Branded Name of Phenylbutazone Tablet</dc:title>
	<dc:creator>Akib, Nur Illiyyin</dc:creator>
	<dc:creator>Husnaeni, Husnaeni</dc:creator>
	<dc:creator>Zubaydah, Wa Ode Sitti</dc:creator>
	<dc:creator>Mallarangeng, Andi Nafisah Tendri Adjeng</dc:creator>
	<dc:description xml:lang="en-US">Physical characterization and equivalence testing of generic and branded names of phenylbutazone tablets have been done. The information about quality of generic drugs is expected to increase the use of generic drugs by health practitioners and public. Dissolution test carried out by in vitro had correlation with bioequivalence by in vivo test. Sample of dissolution testing were generic (G) and branded (A and B) names of 200 mg phenylbutazone tablets. Physical characteristic test performed by uniformity weight test, hardness and disintegration time. Dissolution test were conducted by using basket and spectrophotometry ultra violet method in 200-400 nm wavelength. The result of uniformity weight of generic drug and branded drug was 352,02 mg and 352,82 mg, the hardness of generic was 9,58 kgf and branded was 9,50 kgf, and disintegration test result of generic was 16,1 minutes and branded was 3 minutes. The result of dissolution testing were dissolution profile and dissolved concentration at 30 minutes that compared to qualify of USP XXXII. Relative bioavailability testing of generic to A brand was 101.580 and generic to B brand was 105.275. Based on statistical test, there was no significant different or pharmaceutical equivalent. The generic tablets were equivalent to A and B branded names tablets with similar factors 82.120 and 74.271.Keywords: Equivalence, Dissolution, Salbutamol tablet; generic name, branded name</dc:description>
	<dc:publisher xml:lang="en-US">Fakultas Farmasi Universitas Halu Oleo</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2017-09-16</dc:date>
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	<dc:identifier>https://ojs.uho.ac.id/index.php/pharmauho/article/view/3537</dc:identifier>
	<dc:identifier>10.33772/pharmauho.v3i2.3537</dc:identifier>
	<dc:source xml:lang="en-US">Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan; Vol 3, No 2 (2017): Pharmauho</dc:source>
	<dc:source>2715-4181</dc:source>
	<dc:source>10.33772/pharmauho.v3i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/pharmauho/article/view/3537/2672</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Pharmauho</dc:rights>
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