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The Test of Improvement Activity on Kidney Function by Etanolic Extract of Lansau from Muna Regency on Male Wistar Rat

Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan · Vol. 6 No. 1 (2020) · pp. 33–41

DOI
10.33772/pharmauho.v6i1.11655
ISSN
2715-4181
Published
2020-04-22
Publisher
Fakultas Farmasi Universitas Halu Oleo
Language
eng
License
creativecommons.org/licenses/by-sa/4.0

Abstract

Lansau is one of the traditional ingredients that consist of 44 types of plants that are believed by the local society as a nutritious herb to treat various diseases that exist in the society of Muna Southeast Sulawesi Province that has been used for hundreds of years for generations. The study was conducted to determine the effect of ethanol extract of Lansau on the improvement activity of kidney function that induced gentamicin-piroxicam. A total of 24 rats were used in which 20 ratswere modeled with damage of renal function using gentamicin-piroxicam drug which was then grouped into 5 groups. The first group was treated using a Lansau extract with doseI, the second group was treated with aLansauextract dose II, the third group was treated with the Lansau extract dose III, the fourth group was treated with ketosteryl, the fifth group was no treatment only given Na. 1% CMC and the sixth group is the normal group. The Modeling was performed for 7 days and on the eighth day blood sampling was taken to measure creatinine and urea levels. As for therapy performed for 4 weeks and every end of the week also made blood taking for measurement of creatinine and urea. The highest percentage of creatinin decrease for each group was negative group -8.92%,positive group control was 84.21%,dose group I 74.75%, dose group II 80.07%, and dose group III 84.08%. For the highest percentage of decrease of ureum level for each group that is negative group -31.l49%,positive control group 49.59%,dose group I 40.53%, dose group II 26.79%, and dose group III 43.32%. The results showed that Lansau ethanol extract has the potential and effectiveness in the repair of kidney function damage.

Keywords

Collaboration network of the authors

40 authors · 181 co-authorship links · 2 across different organisations · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Universitas Halu Oleo
  • Institut Teknologi dan Kesehatan Avicenna
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Sabarudin SabarudinUniversitas Halu Oleo9
Ruslin RuslinUniversitas Halu Oleo8
Suryani SuryaniUniversitas Halu Oleo6
S SabarudinAffiliation unknown5
La Ode Muhammad FitrawanUniversitas Halu Oleo4
Nurull HikmahUniversitas Halu Oleo3
Yamin YaminUniversitas Halu Oleo3
Mesi LeoritaAffiliation unknown3
Vica AspadiahAffiliation unknown3
Nurramadhani Armada SidaUniversitas Halu Oleo2
Aswani AswaniUniversitas Halu Oleo2
Arfan ArfanUniversitas Halu Oleo2
Aswani AswaniAffiliation unknown2
Rini HamsidiAffiliation unknown2
Fifi NirmalaUniversitas Halu Oleo2
N NuralifahAffiliation unknown2
Rusliati DamuAffiliation unknown2
Aswan SudimanAffiliation unknown2
Asmaidah JamsirAffiliation unknown2
Wa Ode HasniarAffiliation unknown2
Wanda SeptiyanaAffiliation unknown2
Nur Illiyyin AkibAffiliation unknown2
Andi Nafisah Tendri AdjengAffiliation unknown2
Suryani SuryaniUniversitas Halu Oleo1
Wa Ode Sitti ZubaydahUniversitas Halu Oleo1
Muhammad Handoyo SahumenaUniversitas Halu Oleo1
Alfian AlfianAffiliation unknown1
Ridho Fajriyah JamriAffiliation unknown1
Ari SartinahUniversitas Halu Oleo1
Nur Fitriana Muhammad AliInstitut Teknologi dan Kesehatan Avicenna1
Andi Nafisah Tendri AdjengAffiliation unknown1
Sania HairahAffiliation unknown1
Syahlan HermanAffiliation unknown1
Adryan FristiohadyAffiliation unknown1
Elfira HaringiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/pharmauho/oai, first harvested 30 Okt 2026, last seen 1 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">The Test of Improvement Activity on Kidney Function by Etanolic Extract of Lansau from Muna Regency on Male Wistar Rat</dc:title>
	<dc:creator>Ruslin, R</dc:creator>
	<dc:creator>Kasmawati, Henny</dc:creator>
	<dc:creator>Suryani, S</dc:creator>
	<dc:creator>Ihsan, Sunandar</dc:creator>
	<dc:creator>Soleman, Imelda Sarda</dc:creator>
	<dc:subject xml:lang="en-US">Lansau, Creatinine, Ureum, Gentamicin-Piroxicam</dc:subject>
	<dc:description xml:lang="en-US">Lansau is one of the traditional ingredients that consist of 44 types of plants that are believed by the local society as a nutritious herb to treat various diseases that exist in the society of Muna Southeast Sulawesi Province that has been used for hundreds of years for generations. The study was conducted to determine the effect of ethanol extract of Lansau on the improvement activity of kidney function that induced gentamicin-piroxicam. A total of 24 rats were used in which 20 ratswere modeled with damage of renal function using gentamicin-piroxicam drug which was then grouped into 5 groups. The first group was treated using a Lansau extract with doseI , the second group was treated with aLansauextract dose II, the third group was treated with the Lansau extract dose III, the fourth group was treated with ketosteryl, the fifth group was no treatment only given Na. 1% CMC and the sixth group is the normal group. The Modeling was performed for 7 days and on the eighth day blood sampling was taken to measure creatinine and urea levels. As for therapy performed for 4 weeks and every end of the week also made blood taking for measurement of creatinine and urea. The highest percentage of creatinin decrease for each group was negative group -8.92%,positive group control was 84.21%,dose group I 74.75%, dose group II 80.07%, and dose group III 84.08%. For the highest percentage of decrease of ureum level for each group that is negative group -31.l49%,positive control group 49.59%,dose group I 40.53%, dose group II 26.79%, and dose group III 43.32%. The results showed that Lansau ethanol extract has the potential and effectiveness in the repair of kidney function damage.</dc:description>
	<dc:publisher xml:lang="en-US">Fakultas Farmasi Universitas Halu Oleo</dc:publisher>
	<dc:contributor xml:lang="en-US">Universitas Halu Oleo</dc:contributor>
	<dc:date>2020-04-22</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
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	<dc:identifier>https://ojs.uho.ac.id/index.php/pharmauho/article/view/11655</dc:identifier>
	<dc:identifier>10.33772/pharmauho.v6i1.11655</dc:identifier>
	<dc:source xml:lang="en-US">Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan; Vol 6, No 1 (2020): Pharmauho; 33-41</dc:source>
	<dc:source>2715-4181</dc:source>
	<dc:source>10.33772/pharmauho.v6i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/pharmauho/article/view/11655/8750</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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