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Preparasi Teofilin dalam Pembawa Vesikular Etosom untuk Penggunaan Transdermal

Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan · Vol. 5 No. 1 (2019) · pp. 25–28

DOI
10.33772/pharmauho.v5i1.8998
ISSN
2715-4181
Published
2019-04-16
Publisher
Fakultas Farmasi Universitas Halu Oleo
Language
eng

Abstract

Theophylline is a methyl xanthine of alkaloid derivative compound has been used as a bronchodilator in the treatment of chronic lung disorders, especially asthma. Oral administration of theophylline causes inconvenient for patients including bitter taste, narrow therapeutic range, and indigestion due to increased of gastric acid secretion. Therefore, other administration of theophylline has been developed as transdermal delivery system. This study disscused about preparation of theophylline in ethosome as vesicular carrier. Preparation of ethosome was used hot method (40oC) and cool method (30oC). Characterization of ethosomes includes observation of shape and size of vesicles by microscopic method and the vesicles were fractionated by centrifugation then entrapment efficiency (% EE) were measured by spectrophotometric method. Then optimazed theophylline that entrapped in ethosome. Based on the results, ethosomes preparation by hot method were produced Small Unilamellar Vesicle (SUV), the size were 0,0522-0,100 µm, and the highest value of % EE was 98.95%, while ethosomes preparation by cold method were produced Small Unilamellar Vesicle (SUV), the size were 0.0522-0.100 μm, and the highest value of % EE was 99.80%. The optimum concentration of theophylline was entrapped in etosom was 0.1%. It was concluded that cold method was the appropriate method for preparation of theophylline in ethosome as vesicular carrier.Keywords: Etosome, theophylline, vesicular, transdermal

Collaboration network of the authors

40 authors · 155 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Rini HamsidiAffiliation unknown3
Suryani SuryaniUniversitas Halu Oleo3
Wa Ode Sitti ZubaydahUniversitas Halu Oleo2
Muhammad Handoyo SahumenaUniversitas Halu Oleo2
Ardiyanti ArdiyantiAffiliation unknown1
Nurhayani HMAffiliation unknown1
Muhammad Juharisman SaputraAffiliation unknown1
Wa BaaneAffiliation unknown1
Wahyuni WahyuniAffiliation unknown1
Fery Indradewi ArmadanyAffiliation unknown1
Rifa'atul MahmudahAffiliation unknown1
H HalikAffiliation unknown1
R RamlahAffiliation unknown1
Andi Nafisah Tendri Adjeng MallarangengAffiliation unknown1
Husnaeni HusnaeniAffiliation unknown1
Henny KasmawatiUniversitas Halu Oleo1
S SabarudinAffiliation unknown1
W WahyuniAffiliation unknown1
Muhammad Hajrul MalakaAffiliation unknown1
Aty WidyawaruyantiAffiliation unknown1
Achmad Fuad HafidAffiliation unknown1
Wiwied EkasariAffiliation unknown1
Ari SartinahUniversitas Halu Oleo1
Andi Nafisah Tendri AdjengAffiliation unknown1
Muhammad ArbaAffiliation unknown1
Y YaminAffiliation unknown1
N NurhasanaAffiliation unknown1
Asniar PascayantriAffiliation unknown1
Indria HafizahAffiliation unknown1
Halimahtussaddiyah RitongaAffiliation unknown1
Yunita DawuAffiliation unknown1
Vica AspadiahAffiliation unknown1
Halimahtussaddiyah R Halimahtussaddiyah RAffiliation unknown1
Niken PrawestiAffiliation unknown1
Andi Eka Purnama PutriAffiliation unknown1
Mariani TriwatamiAffiliation unknown1
Sunandar IhsanUniversitas Halu Oleo1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/pharmauho/oai, first harvested 30 Okt 2026, last seen 30 Okt 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Preparasi Teofilin dalam Pembawa Vesikular Etosom untuk Penggunaan Transdermal</dc:title>
	<dc:creator>Akib, Nur Illiyyin</dc:creator>
	<dc:creator>Ritonga, Halimatussadiyah</dc:creator>
	<dc:creator>Mahfuz, Muhammad</dc:creator>
	<dc:description xml:lang="en-US">Theophylline is a methyl xanthine of alkaloid derivative compound has been used as a bronchodilator in the treatment of chronic lung disorders, especially asthma. Oral administration of theophylline causes inconvenient for patients including bitter taste, narrow therapeutic range, and indigestion due to increased of gastric acid secretion. Therefore, other administration of theophylline has been developed as transdermal delivery system. This study disscused about preparation of theophylline in ethosome as vesicular carrier. Preparation of ethosome was used hot method (40oC) and cool method (30oC). Characterization of ethosomes includes observation of shape and size of vesicles by microscopic method and the vesicles were fractionated by centrifugation then entrapment efficiency (% EE) were measured by spectrophotometric method. Then optimazed theophylline that entrapped in ethosome. Based on the results, ethosomes preparation by hot method were produced Small Unilamellar Vesicle (SUV), the size were 0,0522-0,100 µm, and the highest value of % EE was 98.95%, while ethosomes preparation by cold method were produced Small Unilamellar Vesicle (SUV), the size were 0.0522-0.100 μm, and the highest value of % EE was 99.80%. The optimum concentration of theophylline was entrapped in etosom was 0.1%. It was concluded that cold method was the appropriate method for preparation of theophylline in ethosome as vesicular carrier.Keywords: Etosome, theophylline, vesicular, transdermal</dc:description>
	<dc:publisher xml:lang="en-US">Fakultas Farmasi Universitas Halu Oleo</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2019-04-16</dc:date>
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	<dc:identifier>https://ojs.uho.ac.id/index.php/pharmauho/article/view/8998</dc:identifier>
	<dc:identifier>10.33772/pharmauho.v5i1.8998</dc:identifier>
	<dc:source xml:lang="en-US">Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan; Vol 5, No 1 (2019): Pharmauho; 25-28</dc:source>
	<dc:source>2715-4181</dc:source>
	<dc:source>10.33772/pharmauho.v5i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/pharmauho/article/view/8998/8767</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 Pharmauho</dc:rights>
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