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UJI DAYA HAMBAT EKSTRAK DAUN SIRSAK (Annona muricata L.) DAN DAUN SIRIH (Piper betle L.) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli

MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) · Vol. 1 No. 2 (2015)

DOI
10.46496/medula.v1i2.197
ISSN
2443-0218, 2339-1006
Published
2015-03-31
Publisher
Halu Oleo University
Language
eng

Abstract

Soursop (A. muricata L.) and betel (P. betle L.) are common plants that traditionally used as a medicine. The aims of this study are to determine the Minimum Inhibitory Concentration (MIC) of soursop leaves benefits and betel leaves extract that can inhibit the growth of E. coli one of the cause of diarrhea and the most potentially extract between that plants. Methode of this research used post test control only design and cotrimoxazole (as a control). This study consists of three phases: (1)sample preparation, (2)extraction by maceration with methanol and obtained as much as 14.97 g of leaf extract of A. muricata.L and 2.88 g of P. betle L. after evaporated, (3)MIC using the disc diffusion method. The concentration of each extract are 80,000 ppm, 40,000 ppm, 20,000 ppm, 10,000 ppm, 5000 ppm, 2500 ppm, and 1250 ppm. Ten μL of each extracts was taken and saturated to a paper disc. The results of this study showed that the A. muricata L leaf extract begin to show inhibition at concentration 2500 ppm and P. betle.L is at concentration 5.000 ppm. The conclusion of this study is the MIC of A. muricata L. and P. betle L.leaf extract are 2500 ppm and 5000 ppm sequentially.Key words: A. muricata L., P. betle L., Minimum Inhibitory concentration, E. coli

Collaboration network of the authors

18 authors · 32 co-authorship links

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  • Universitas Halu Oleo
  • Institut Agama Islam Negeri Kendari
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Indria HafizahAffiliation unknown3
Lezdyana Nur IslamiAffiliation unknown2
Riszki RiszkiAffiliation unknown1
Fine Farhani MuliatiAffiliation unknown1
Fifit ErvithaAffiliation unknown1
Wa Ode Sitti Asfiah UduAffiliation unknown1
Wa Ode Sitti Asfiah UduAffiliation unknown1
I Putu SudayasaAffiliation unknown1
Muhamad Rifki HidayatAffiliation unknown1
Ummi KalsumInstitut Agama Islam Negeri Kendari1
Pranita AritrinaAffiliation unknown1
Natalis RansiUniversitas Halu Oleo1
Arman ArmanUniversitas Halu Oleo1
Edi CahyonoUniversitas Halu Oleo1
Ambo Wonua NusantaraAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/medula/oai, first harvested 31 Okt 2026, last seen 1 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">UJI DAYA HAMBAT EKSTRAK DAUN SIRSAK (Annona muricata L.) DAN DAUN SIRIH (Piper betle L.) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli</dc:title>
	<dc:creator>Fitria, Eka Suci</dc:creator>
	<dc:creator>Imran, Imran</dc:creator>
	<dc:creator>Sulastrianah, Sulastrianah</dc:creator>
	<dc:description xml:lang="en-US">Soursop (A. muricata L.) and betel (P. betle L.) are common plants that traditionally used as a medicine. The aims of this study are to determine the Minimum Inhibitory Concentration (MIC) of soursop leaves benefits and betel leaves extract that can inhibit the growth of E. coli one of the cause of diarrhea and the most potentially extract between that plants. Methode of this research used post test control only design and cotrimoxazole (as a control). This study consists of three phases : (1)sample preparation, (2)extraction by maceration with methanol and obtained as much as 14.97 g of leaf extract of A. muricata.L and 2.88 g of P. betle L. after evaporated, (3)MIC using the disc diffusion method. The concentration of each extract are 80,000 ppm, 40,000 ppm, 20,000 ppm, 10,000 ppm, 5000 ppm, 2500 ppm, and 1250 ppm. Ten μL of each extracts was taken and saturated to a paper disc. The results of this study showed that the A. muricata L leaf extract begin to show inhibition at concentration 2500 ppm and P. betle.L is at concentration 5.000 ppm. The conclusion of this study is the MIC of A. muricata L. and P. betle L.leaf extract are 2500 ppm and 5000 ppm sequentially.Key words: A. muricata L., P. betle L., Minimum Inhibitory concentration, E. coli</dc:description>
	<dc:publisher xml:lang="en-US">Halu Oleo University</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2015-03-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ojs.uho.ac.id/index.php/medula/article/view/197</dc:identifier>
	<dc:identifier>10.46496/medula.v1i2.197</dc:identifier>
	<dc:source xml:lang="en-US">MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO); Vol 1, No 2 (2014)</dc:source>
	<dc:source>2443-0218</dc:source>
	<dc:source>2339-1006</dc:source>
	<dc:source>10.46496/medula.v1i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/medula/article/view/197/137</dc:relation>
</oai_dc:dc>