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Uji Antidiabetik Ekstrak Buah Pare (Momordica charantia L.) terhadap Penurunan Kadar Glukosa Darah pada Mencit yang Diinduksi Streptozotocin

MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) · Vol. 5 No. 1 (2018)

DOI
10.46496/medula.v5i1.3889
ISSN
2443-0218, 2339-1006
Published
2018-04-12
Publisher
Halu Oleo University
Language
eng

Abstract

ABSTRACT Diabetes mellitus is a chronic disease in which the patient has excess glucose levels in the blood. Pare (Momordica charantia L.) is one of the plants that have efficacy in treating various diseases one of them is antidiabetes. Activity of active substances from the pare may play a role in lowering blood sugar levels. This research is done to know the effect of increasing concentration of pare extract to decrease blood glucose level in mice induced by streptozotocin.This study was experimental laboratory, the study was done by measured the initial blood sugar level in mice, sugar content after induction of steptozotosin, and after administration of 100 mg / kgBW extract test, 250 mg / kgBW and 400 mg / kgBW with observation time for 7 days, as well as gave metformin suspension as a positive control.The results showed that the optimum value of antidiabetic activity of ethanol extract of pare fruit at a concentration of 400 mg / kgBW and had an average decrease of 122 mg / dl.Keywords: Antidiabetes, Momordica charantia L., Streptozotocin

Collaboration network of the authors

40 authors · 88 co-authorship links

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  • Universitas Halu Oleo
  • Institut Agama Islam Negeri Kendari
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
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Co-authorOrganisationJoint articles
Tien TienAffiliation unknown2
Nurlliyin AkibAffiliation unknown2
Geong AntrieAffiliation unknown2
I Putu SudayasaAffiliation unknown2
Misdayanti TakdirAffiliation unknown2
Amiruddin EAffiliation unknown2
Feri IndradewiAffiliation unknown2
Satriana NasrunAffiliation unknown2
Wa Ode Sitti Asfiah UduAffiliation unknown2
Indah PurnamasariAffiliation unknown2
Annisa SyasnaAffiliation unknown2
Dian MunasariAffiliation unknown2
L.O.M. FitrawanAffiliation unknown2
Sari Melyana MuslihinAffiliation unknown2
Indriah HafizahAffiliation unknown1
Rahma WatiAffiliation unknown1
Sapto RaharjoAffiliation unknown1
Agus ChahyadiAffiliation unknown1
Aulia FadhilahAffiliation unknown1
Sjarif SubijaktoAffiliation unknown1
Muh. Ikhsan Fadli NanlohyAffiliation unknown1
La RangkiAffiliation unknown1
Junuda JunudaAffiliation unknown1
Mutmainna MutmainnaAffiliation unknown1
Yenti PurnamasariAffiliation unknown1
Fifi NirmalaUniversitas Halu Oleo1
Pranita AritrinaAffiliation unknown1
Hartati HartatiInstitut Agama Islam Negeri Kendari1
Lista Yul ZamrulAffiliation unknown1
Muhammad Ilyas YusufAffiliation unknown1
Sifak GiatnaAffiliation unknown1
Wahyuni WahyuniAffiliation unknown1
Zakiyatul MahmudahAffiliation unknown1
Erik Veri RamadaniAffiliation unknown1
Junuda RAFAffiliation unknown1
Agussalim AliAffiliation unknown1
Nabila ShaddadAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/medula/oai, first harvested 31 Okt 2026, last seen 1 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Uji Antidiabetik Ekstrak Buah Pare (Momordica charantia L.) terhadap Penurunan Kadar Glukosa Darah pada Mencit  yang Diinduksi Streptozotocin</dc:title>
	<dc:creator>Parawansah, Parawansah</dc:creator>
	<dc:creator>Nuralifah, Nuralifah</dc:creator>
	<dc:creator>Kholidha, Andi Noor</dc:creator>
	<dc:description xml:lang="en-US">ABSTRACT Diabetes mellitus is a chronic disease in which the patient has excess glucose levels in the blood. Pare (Momordica charantia L.) is one of the plants that have efficacy in treating various diseases one of them is antidiabetes. Activity of active substances from the pare may play a role in lowering blood sugar levels. This research is done to know the effect of increasing concentration of pare extract to decrease blood glucose level in mice induced by streptozotocin.This study was experimental laboratory, the study was done by measured  the initial blood sugar level in mice, sugar content after induction of steptozotosin, and after administration of 100 mg / kgBW extract test, 250 mg / kgBW and 400 mg / kgBW with observation time for 7 days , as well as gave metformin suspension as a positive control.The results showed that the optimum value of antidiabetic activity of ethanol extract of pare fruit at a concentration of 400 mg / kgBW and had an average decrease of 122 mg / dl.Keywords: Antidiabetes, Momordica charantia L., Streptozotocin</dc:description>
	<dc:publisher xml:lang="en-US">Halu Oleo University</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2018-04-12</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ojs.uho.ac.id/index.php/medula/article/view/3889</dc:identifier>
	<dc:identifier>10.46496/medula.v5i1.3889</dc:identifier>
	<dc:source xml:lang="en-US">MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO); Vol 5, No 1 (2017)</dc:source>
	<dc:source>2443-0218</dc:source>
	<dc:source>2339-1006</dc:source>
	<dc:source>10.46496/medula.v5i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/medula/article/view/3889/2969</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Medula</dc:rights>
</oai_dc:dc>