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Formulasi Sediaan Krim Anti Jerawat Ekstrak Etanol Biji Pepaya Muda (Carica papaya L.) Serta Uji Aktivitasnya Terhadap Bakteri Pseudomonas aeruginosaATCC 27825 dan Staphylococcus aureusATCC 25923 (Anti Acne Cream Formulation for Young Papaya Seed (Carica papaya L.) Ethanol Extract and Activity Test Against Pseudomonas aeruginosa ATCC 27825 and Staphylococcus aureus ATCC 25923)

MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) · Vol. 7 No. 1 (2020)

DOI
10.46496/medula.v7i1.11493
ISSN
2443-0218, 2339-1006
Published
2020-04-26
Publisher
Halu Oleo University
Language
eng

Abstract

Background: Young papaya seeds (Carica papaya L.) contained terpenoids, alkaloids karpain and flavonoids that have been examined has antibacterial activity. Purpose: This study aims to obtain anti-acne cream from extract of young papaya seeds (Carica papaya L.) that possess antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27825. Methods: Extract of young papaya seeds (Carica papaya L.) was obtained by maceration process using ethanol 96% and the antibacterial activity of extract conducted by well diffusion method. then the extract formulated into anti acne cream dosage and then tested to characteristic properties including pH test, dispersive power test, organoleptic test, homogeneity test, viscosity test and irritation test. Result: The results showed anti acne creams of extract young papaya seeds (Carica papaya L.) produced qualified standard and did not cause irritation. Conclusion: Anti acne cream containing extract concentration of 10% can inhibited bacteria of S. aureus ATCC 25923 with inhibition zone of 17,5 mm and P. aeruginosa ATCC 27825 with inhibition zone of 19,3 mm.Keyword: seeds of papaya (Carica papaya L.), anti acne creamLatar Belakang: Biji pepaya muda (Carica papaya L) mengandung terpenoid, alkaloid karpain dan flavonoid, yang telah diteliti memiliki aktivitas antibakteri. Tujuan: Penelitian ini bertujuan untuk memperoleh sediaan krim anti jerawat dari ekstrak biji pepaya muda (Carica papaya L) yang memiliki aktivitas anti bakteri terhadap bakteri Staphylococcus aureus ATCC 25923 dan Pseudomonas aureginosa ATCC 27825. Metode: Ekstrak biji pepaya muda (Carica papaya L) diperoleh melalui proses maserasi menggunakan pelarut etanol 96%, serta uji aktivitas antibakteri ekstrak dilakukan dengan metode sumuran. Ekstrak selanjutnya diformulasikan menjadi sediaan krim anti jerawat dan dilakukan uji karakterisasi meliputi uji pH, uji daya sebar, uji organoleptik, uji homogenitas, uji viskositas dan uji iritasi. Hasil: Hasil pengamatan menunjukkan sediaan krim anti jerawat ekstrak biji pepaya muda (Carica papaya L) yang dihasilkan memenuhi syarat standar nilai pH, daya sebar dan viskositas. Hasil uji iritasi memperlihatkan formula krim tidak menimbulkan iritasi. Simpulan: Sediaan krim anti jerawat dengan konsentrasi ekstrak 10% dapat menghambat bakteri S.aureus ATCC 25923 dengan hambatan sebesar 17,5 mm dan P. aeruginosa ATCC 27825 dengan hambatan sebesar 19,3 mm.Kata Kunci: biji pepaya muda (Carica papaya L), krim anti jerawat

Collaboration network of the authors

27 authors · 58 co-authorship links

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  • Institut Agama Islam Negeri Kendari
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Andi Noor KholidhaAffiliation unknown3
Nurlliyin AkibAffiliation unknown2
Geong AntrieAffiliation unknown2
Wa Ode Sitti Asfiah UduAffiliation unknown2
Indah PurnamasariAffiliation unknown2
Annisa SyasnaAffiliation unknown2
Dian MunasariAffiliation unknown2
L.O.M. FitrawanAffiliation unknown2
Sari Melyana MuslihinAffiliation unknown2
I Putu SudayasaAffiliation unknown1
Misdayanti TakdirAffiliation unknown1
Amiruddin EAffiliation unknown1
Muh. Ikhsan Fadli NanlohyAffiliation unknown1
La RangkiAffiliation unknown1
Junuda JunudaAffiliation unknown1
Mutmainna MutmainnaAffiliation unknown1
Yenti PurnamasariAffiliation unknown1
Hartati HartatiInstitut Agama Islam Negeri Kendari1
Lista Yul ZamrulAffiliation unknown1
Muhammad Ilyas YusufAffiliation unknown1
Sifak GiatnaAffiliation unknown1
Wahyuni WahyuniAffiliation unknown1
Zakiyatul MahmudahAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/medula/oai, first harvested 31 Okt 2026, last seen 1 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Formulasi Sediaan Krim Anti Jerawat Ekstrak Etanol Biji Pepaya Muda (Carica papaya L.) Serta Uji Aktivitasnya Terhadap Bakteri Pseudomonas aeruginosaATCC 27825 dan Staphylococcus aureusATCC 25923  (Anti Acne Cream Formulation for Young Papaya Seed (Carica papaya L.) Ethanol Extract and Activity Test Against Pseudomonas aeruginosa ATCC 27825 and Staphylococcus aureus ATCC 25923)</dc:title>
	<dc:creator>Nuralifah, Nuralifah</dc:creator>
	<dc:creator>Indradewi, Feri</dc:creator>
	<dc:creator>Parawansah, Parawansah</dc:creator>
	<dc:creator>Nasrun, Satriana</dc:creator>
	<dc:description xml:lang="en-US">Background: Young papaya seeds (Carica papaya L.) contained terpenoids, alkaloids karpain and flavonoids that have been examined has antibacterial activity. Purpose: This study aims to obtain anti-acne cream from extract of young papaya seeds (Carica papaya L.) that possess antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27825. Methods: Extract of young papaya seeds (Carica papaya L.) was obtained by maceration process using ethanol 96% and the antibacterial activity of extract conducted by well diffusion method. then the extract formulated into anti acne cream dosage and then tested to characteristic properties including pH test, dispersive power test, organoleptic test, homogeneity test, viscosity test and irritation test. Result: The results showed anti acne creams of extract young papaya seeds (Carica papaya L.) produced qualified standard and did not cause irritation. Conclusion: Anti acne cream containing extract concentration of 10% can inhibited bacteria of S. aureus ATCC 25923 with inhibition zone of 17,5 mm and P. aeruginosa ATCC 27825 with inhibition zone of 19,3 mm.Keyword: seeds of papaya (Carica papaya L.), anti acne creamLatar Belakang: Biji pepaya muda (Carica papaya L) mengandung terpenoid, alkaloid karpain dan flavonoid, yang telah diteliti memiliki aktivitas antibakteri. Tujuan: Penelitian ini bertujuan untuk memperoleh sediaan krim anti jerawat dari ekstrak biji pepaya muda (Carica papaya L) yang memiliki aktivitas anti bakteri terhadap bakteri Staphylococcus aureus ATCC 25923 dan Pseudomonas aureginosa ATCC 27825. Metode: Ekstrak biji pepaya muda (Carica papaya L) diperoleh melalui proses maserasi menggunakan pelarut etanol 96%, serta uji aktivitas antibakteri ekstrak dilakukan dengan metode sumuran. Ekstrak selanjutnya diformulasikan menjadi sediaan krim anti jerawat dan dilakukan uji karakterisasi meliputi uji pH, uji daya sebar, uji organoleptik, uji homogenitas, uji viskositas dan uji iritasi. Hasil: Hasil pengamatan menunjukkan sediaan krim anti jerawat ekstrak biji pepaya muda (Carica papaya L) yang dihasilkan memenuhi syarat standar nilai pH, daya sebar dan viskositas. Hasil uji iritasi memperlihatkan formula krim tidak menimbulkan iritasi. Simpulan: Sediaan krim anti jerawat dengan konsentrasi ekstrak 10% dapat menghambat bakteri S.aureus ATCC 25923 dengan hambatan sebesar 17,5 mm dan P. aeruginosa ATCC 27825 dengan hambatan sebesar 19,3 mm.Kata Kunci: biji pepaya muda (Carica papaya L), krim anti jerawat</dc:description>
	<dc:publisher xml:lang="en-US">Halu Oleo University</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2020-04-26</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ojs.uho.ac.id/index.php/medula/article/view/11493</dc:identifier>
	<dc:identifier>10.46496/medula.v7i1.11493</dc:identifier>
	<dc:source xml:lang="en-US">MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO); Vol 7, No 1 (2019)</dc:source>
	<dc:source>2443-0218</dc:source>
	<dc:source>2339-1006</dc:source>
	<dc:source>10.46496/medula.v7i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/medula/article/view/11493/8054</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 MEDULA</dc:rights>
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