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PREPARASI FENILBUTAZON DALAM PEMBAWA VESIKULAR ETOSOM DENGAN BERBAGAI VARIASI KONSENTRASI FOSFATIDILKOLIN DAN ETANOL

MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) · Vol. 2 No. 1 (2015)

DOI
10.46496/medula.v2i1.243
ISSN
2443-0218, 2339-1006
Published
2015-06-01
Publisher
Halu Oleo University
Language
eng

Abstract

Phenylbutazone is non steroidal anti-inflammatory drug (NSAID) used in treatment of joint inflammation such as rheumathoid arthritis. In order to minimize irritation effect on gastrointestinal tract, the dose of phenylbutazone is reduced or administered through transdermal pathways. Flux penetration of drugs across the membrane can be improved by using vesicular type of delivery system such as ethosome. This study aim to prepare phenylbutazone in ethosome vesicular system. Ethosome vesicular systems were prepared with various concentrations of phosphatidylcholine (2% and 3%) and ethanol (30%, 35%, and 40%). Vesicles that are formed further characterized by shape, size and entrapment efficiency. The shaped of ethosome produced is large unilamellar vesicle. The size of vesicle varies between 0.57 to 0.81 µm with the smallest size on Formula C. The highest entrapment efficiencies was also on the Formula C by 59.88% with 2% concentration of phosphatidylcholine and 40% of ethanol. Keywords: phenylbutazone, vesicle, ethosomes.

Collaboration network of the authors

40 authors · 131 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Henny KasmawatiUniversitas Halu Oleo6
Ruslin RuslinUniversitas Halu Oleo4
Rini HamsidiAffiliation unknown4
Nurull HikmahUniversitas Halu Oleo2
La Ode Muhammad FitrawanUniversitas Halu Oleo2
Wa Ode Sitti ZubaydahUniversitas Halu Oleo2
Wahyuni WahyuniAffiliation unknown2
Fery Indradewi ArmadanyAffiliation unknown2
Andi Eka Purnama PutriAffiliation unknown2
Ari SartinahUniversitas Halu Oleo2
Halimahtussaddiyah RitongaAffiliation unknown2
Vica AspadiahAffiliation unknown2
Sunandar IhsanUniversitas Halu Oleo2
Nurramadhani Armada SidaUniversitas Halu Oleo1
Aswani AswaniUniversitas Halu Oleo1
Nurlena IkawatiAffiliation unknown1
Ardiyanti ArdiyantiAffiliation unknown1
Nurhayani HMAffiliation unknown1
Muhammad Juharisman SaputraAffiliation unknown1
Wa BaaneAffiliation unknown1
Muhammad KamalAffiliation unknown1
Akhir PurwatiAffiliation unknown1
Wa Ode Sitti MusninaAffiliation unknown1
Aisyah Shaliha AntoAffiliation unknown1
Irnawati IrnawatiAffiliation unknown1
Irmanaya SariAffiliation unknown1
Rifa'atul MahmudahAffiliation unknown1
H HalikAffiliation unknown1
R RamlahAffiliation unknown1
Wa Ode Hastriani FitrihAffiliation unknown1
Andi Nafisah Tendri Adjeng MallarangengAffiliation unknown1
Husnaeni HusnaeniAffiliation unknown1
Muhammad Hajrul MalakaAffiliation unknown1
Aty WidyawaruyantiAffiliation unknown1
Achmad Fuad HafidAffiliation unknown1
Wiwied EkasariAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/medula/oai, first harvested 31 Okt 2026, last seen 1 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">PREPARASI FENILBUTAZON DALAM PEMBAWA VESIKULAR  ETOSOM DENGAN BERBAGAI VARIASI KONSENTRASI  FOSFATIDILKOLIN DAN ETANOL</dc:title>
	<dc:creator>Akib, Nur Illiyyin</dc:creator>
	<dc:creator>Suryani, Suryani</dc:creator>
	<dc:creator>Halimahtussaddiyah R, Halimahtussaddiyah R</dc:creator>
	<dc:creator>Prawesti, Niken</dc:creator>
	<dc:description xml:lang="en-US">Phenylbutazone is non steroidal anti-inflammatory drug (NSAID) used  in treatment of joint inflammation such  as  rheumathoid  arthritis.  In  order  to  minimize  irritation  effect  on  gastrointestinal  tract,  the  dose  of phenylbutazone is reduced or administered through transdermal pathways. Flux penetration of drugs across the membrane  can  be  improved  by  using  vesicular  type  of  delivery  system  such  as  ethosome.  This  study  aim  to prepare  phenylbutazone in  ethosome  vesicular  system.  Ethosome vesicular  systems  were prepared  with  various concentrations  of  phosphatidylcholine  (2%  and  3%)  and  ethanol  (30%,  35%,  and  40%).  Vesicles  that  are formed  further  characterized  by  shape,  size  and  entrapment  efficiency.  The  shaped  of  ethosome  produced  is large  unilamellar vesicle.  The size of vesicle  varies  between  0.57 to 0.81  µm  with  the smallest size  on Formula C.  The  highest  entrapment  efficiencies  was  also  on  the  Formula  C  by  59.88%  with  2%  concentration  of phosphatidylcholine and 40% of ethanol. Keywords: phenylbutazone, vesicle, ethosomes.</dc:description>
	<dc:publisher xml:lang="en-US">Halu Oleo University</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2015-06-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ojs.uho.ac.id/index.php/medula/article/view/243</dc:identifier>
	<dc:identifier>10.46496/medula.v2i1.243</dc:identifier>
	<dc:source xml:lang="en-US">MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO); Vol 2, No 1 (2014)</dc:source>
	<dc:source>2443-0218</dc:source>
	<dc:source>2339-1006</dc:source>
	<dc:source>10.46496/medula.v2i1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/medula/article/view/243/183</dc:relation>
</oai_dc:dc>