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Activity Antidiabetic Of The Ethanol Extract Green Gedi Leaves Medical) On Mice (Mus musculus

MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) · Vol. 6 No. 3 (2019)

DOI
10.46496/medula.v6i3.9653
ISSN
2443-0218, 2339-1006
Published
2019-11-28
Publisher
Halu Oleo University
Language
eng

Abstract

ABSTRACTBackground: Green gedi leaves (Abelmoschus manihot (L.) Medik) is one plant that has efficacy in treating various diseases one of which is antidiabetic. The nature of the active substance green gedi leaves that capable lower blood glucose levels are flavonoids. Purpose: The purpose of this study was to determine the effective concentration of the extract of green gedi leaves (Abelmoschus manihot (L.) Medik) to lower the blood glucose levels on mice Induced by Streptozotocin. Method: This type of research is experimental research that consists of 5 treatments with 3 variations dose and 2 controls. The study was conducted by measuring the blo od glucose levels in mice, blood glucose levels after induction to return normal blood glucose levels after oral administration with a suspension of Na. CMC as a control, and the suspension glibenclamid as a comparison with the extract of green gedi leaves concentration of 30 mg/KgBB, 60 mg/KgBB and 90 mg/KgBB with a time of observation for seven days. Result: The data obtained were analyzed using ANOVA and LSD. Conclusion: From this study that the green gedi leaf extract (Abelmoschus manihot (L.) Medik) at a concentration of 90 mg/kgBB is more effectife to give antidiabetic effect with the average reduction in blood glucose levels reach 68,67 mg/dL to mice.Keywords: antidiabetic, abelmoschus manihot (L.) Medik, green gedi leaves, Streptozotocin

Collaboration network of the authors

27 authors · 58 co-authorship links

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  • Institut Agama Islam Negeri Kendari
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
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Co-authorOrganisationJoint articles
Nuralifah NuralifahAffiliation unknown5
Andi Noor KholidhaAffiliation unknown2
Nurlliyin AkibAffiliation unknown1
Geong AntrieAffiliation unknown1
I Putu SudayasaAffiliation unknown1
Misdayanti TakdirAffiliation unknown1
Amiruddin EAffiliation unknown1
Muh. Ikhsan Fadli NanlohyAffiliation unknown1
La RangkiAffiliation unknown1
Junuda JunudaAffiliation unknown1
Mutmainna MutmainnaAffiliation unknown1
Yenti PurnamasariAffiliation unknown1
Feri IndradewiAffiliation unknown1
Satriana NasrunAffiliation unknown1
Hartati HartatiInstitut Agama Islam Negeri Kendari1
Lista Yul ZamrulAffiliation unknown1
Muhammad Ilyas YusufAffiliation unknown1
Sifak GiatnaAffiliation unknown1
Wahyuni WahyuniAffiliation unknown1
Zakiyatul MahmudahAffiliation unknown1
Wa Ode Sitti Asfiah UduAffiliation unknown1
Indah PurnamasariAffiliation unknown1
Annisa SyasnaAffiliation unknown1
Dian MunasariAffiliation unknown1
L.O.M. FitrawanAffiliation unknown1
Sari Melyana MuslihinAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/medula/oai, first harvested 31 Okt 2026, last seen 1 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">Activity Antidiabetic Of The Ethanol Extract Green Gedi Leaves Medical) On Mice (Mus musculus</dc:title>
	<dc:creator>Parawansah, Parawansah</dc:creator>
	<dc:description xml:lang="en-US">ABSTRACTBackground: Green  gedi leaves  (Abelmoschus manihot (L.)  Medik)  is one plant that has efficacy in treating various diseases one of which is antidiabetic. The nature of the active substance green gedi leaves that capable lower blood glucose levels are flavonoids. Purpose: The purpose of this  study  was  to  determine  the effective  concentration  of  the  extract  of  green  gedi  leaves (Abelmoschus  manihot  (L.)  Medik)  to  lower  the  blood  glucose  levels on  mice  Induced  by Streptozotocin. Method: This type of research is experimental research that consists of 5 treatments with 3 variations dose and 2 controls. The study was conducted by measuring the blo od glucose levels in mice, blood glucose levels after induction to return normal blood glucose levels after oral administration with a suspension of Na. CMC as a control, and the suspension glibenclamid as a comparison with the extract of green gedi leaves concentration of 30 mg/KgBB, 60 mg/KgBB and 90 mg/KgBB with a time of observation for seven days. Result: The data obtained were analyzed using ANOVA and LSD. Conclusion: From this study that the green gedi leaf extract (Abelmoschus manihot (L.) Medik) at a concentration of 90 mg/kgBB is more effectife to give antidiabetic effect with the average reduction in blood glucose levels reach 68,67 mg/dL to mice.Keywords: antidiabetic, abelmoschus manihot (L.) Medik, green gedi leaves, Streptozotocin</dc:description>
	<dc:publisher xml:lang="en-US">Halu Oleo University</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2019-11-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ojs.uho.ac.id/index.php/medula/article/view/9653</dc:identifier>
	<dc:identifier>10.46496/medula.v6i3.9653</dc:identifier>
	<dc:source xml:lang="en-US">MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO); Vol 6, No 3 (2019): Edisi Suplemen</dc:source>
	<dc:source>2443-0218</dc:source>
	<dc:source>2339-1006</dc:source>
	<dc:source>10.46496/medula.v6i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/medula/article/view/9653/6838</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 MEDULA</dc:rights>
</oai_dc:dc>