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Jurnal

KAJIAN IN VITRO KHASIAT EKSTRAK ETANOL DARI MINUMAN TEH LANSAU KHAS SUKU MUNA

Jurnal Sains dan Teknologi Pangan · Vol. 5 No. 3 (2020)

DOI
10.33772/jstp.v5i3.13114
ISSN
2527-6271
Published
2020-07-26
Publisher
JURUSAN ILMU DAN TEKNOLOGI PANGAN, UNIVERSITAS HALU OLEO
Language
eng

Abstract

ABSTRACTLansau is a traditional medicinal herb of the Muna tribe consisting of 44 types of medicinal plants. Application of Lansau in the Muna community empirically can overcome various degenerative diseases such as diabetes, hypertension, improvement of kidney function, and other degenerative diseases. This study aimed to analyze the safety of Lansau medicinal herb using an acute toxicity test for ethanol extract of Lansau medicinal herb through the calculation of LD50 (Lethal dose 50) value and histopathological observation of the lung, liver, and kidney of the male Wistar strain. Twenty-five male Wistar rats were divided into five groups namely KN group (0.5% NaCMC), LS1 group (28.6 mg/kgbw), LS2 group (57.2 mg/kgbw), LS3 group (114.4 mg/kgbw), and LS4 group (228.8 mg/kgbw). The Lansau extract was given through a single oral route and then the behavior and motoric activity of rats were observed from days 0-14. The results show that no animals died until 14-day of all dosage groups; thus, the LD50 (Lethal dose 50) value could not be concluded yet. Observation of behavior and motoric activity shows some decrease in the activity of rats (grooming, looking up and down, hanging, urinating, defying, etc.). Histopathological data of the lungs show that the lungs were still normal while histopathological data of the liver show necrosis in the LS4 group. The histopathological data of the kidney show normal conditions.Keywords: Acute Toxicity Test, Lansau, LD50.ABSTRAKLansau adalah ramuan obat tradisional khas suku Muna yang terdiri dari 44 jenis tanaman obat. Penggunaan Lansau dimasyarakat Muna secara empiris mampu mengatasi berbagai penyakit degeneratif seperti Diabetes Militus, Hipertensi, Perbaikan fungsi Ginjal dan penyakit degeneratif lainnya. Untuk mengetahui keamaman penggunaan ramuan obat Lansau maka dilakukan uji toksisitas akut ekstrak etanol ramuan obat Lansau melalui perhitungan nilai LD50 (Lethal dose 50) dan pengamatan histopatologi organ paru-paru, hati dan ginjal tikus putih jantan galur wistar. Tikus jantan wistar yang digunakan berjumlah 25 ekor yang terbagi menjadi 5 kelompok yaitu kelompok KN (NaCMC 0,5%), kelompok LS 1 (28,6 mg/kgbb), kelompok LS 2 (57,2 mg/kgbb), kelompok LS 3 (114,4 mg/kgbb) dan kelompok LS 4 ( 228,8 mg/kgbb ). Pemberian sediaan ekstrak etanol Lansau diberikan melalui rute peroral dengan dosis tunggal kemudian diamati Perilaku dan aktivitas motorik tikus dari hari 0-14. Hasil penelitian menunjukan tidak ada hewan yang mati hingga hari ke-14 dari semua kelompok dosis sehingga nilai LD50 (Lethal dose 50) belum dapat disimpulkan. Pengamatan perilaku dan aktivitas motorik menunujukan beberapa penurunan respon keaktifan tikus (Grooming, menengok atas dan bawah, menggantung, urinasi, defikasi dan lain-lain). Data hasil histopatologi organ paru-paru menunjukan organ paru-paru masih normal, data histopatologi organ hati menunjukan terjadinya nekrosis pada kelompok LS 4, data hitopatologi organ ginjal menunjukan keadaan normal.Keyword: Lansau, LD50,Uji Toksisitas Akut

Collaboration network of the authors

40 authors · 169 co-authorship links · showing the 40 most connected

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Sunandar IhsanUniversitas Halu Oleo8
Nurull HikmahUniversitas Halu Oleo8
La Ode Muhammad FitrawanUniversitas Halu Oleo8
Sabarudin SabarudinUniversitas Halu Oleo7
Yamin YaminUniversitas Halu Oleo5
Nurramadhani Armada SidaUniversitas Halu Oleo5
Aswani AswaniUniversitas Halu Oleo5
Aswani AswaniAffiliation unknown4
Nur Illiyyin AkibAffiliation unknown4
S SabarudinAffiliation unknown3
Rini HamsidiAffiliation unknown3
Mentarry BafadalAffiliation unknown3
Wahyuni WahyuniAffiliation unknown3
La AbaUniversitas Halu Oleo2
Fahyuddin FahyuddinAffiliation unknown2
Abraham RahmanAffiliation unknown2
La HarimuAffiliation unknown2
Muhammad ArbaAffiliation unknown2
Sahidin SahidinAffiliation unknown2
Adryan FristiohadyAffiliation unknown2
Rina AndrianiAffiliation unknown2
Suryani SuryaniUniversitas Halu Oleo2
Muhammad Hajrul MalakaAffiliation unknown2
Andi Nafisah Tendri AdjengAffiliation unknown2
Halimahtussaddiyah RitongaAffiliation unknown2
Rina AndriyaniAffiliation unknown1
Syahabudin SyahabudinAffiliation unknown1
Syahbudin SyahbudinUniversitas Halu Oleo1
Nanik HindaryatiningsihUniversitas Halu Oleo1
La Ode NggawuUniversitas Halu Oleo1
Rifa’atul MahmuddahUniversitas Halu Oleo1
Fifi Nirmala GUniversitas Halu Oleo1
Sari Sukmawati KapotaUniversitas Halu Oleo1
Hasyim AbdillahUniversitas Halu Oleo1
Irmanaya SariAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ojs.uho.ac.id/index.php/jstp/oai, first harvested 31 Okt 2026, last seen 31 Okt 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">KAJIAN IN VITRO KHASIAT EKSTRAK ETANOL DARI MINUMAN TEH LANSAU KHAS SUKU MUNA</dc:title>
	<dc:creator>Suryani, Suryani</dc:creator>
	<dc:creator>Kasmawati, Henny</dc:creator>
	<dc:creator>Ruslin, Ruslin</dc:creator>
	<dc:creator>Wardana, Gede Yogi Prana</dc:creator>
	<dc:creator>Aspadiah, Vica</dc:creator>
	<dc:description xml:lang="en-US">ABSTRACTLansau is a traditional medicinal herb of the Muna tribe consisting of 44 types of medicinal plants. Application of Lansau in the Muna community empirically can overcome various degenerative diseases such as diabetes, hypertension, improvement of kidney function, and other degenerative diseases. This study aimed to analyze the safety of Lansau medicinal herb using an acute toxicity test for ethanol extract of Lansau medicinal herb through the calculation of LD50 (Lethal dose 50) value and histopathological observation of the lung, liver, and kidney of the male Wistar strain. Twenty-five male Wistar rats were divided into five groups namely KN group (0.5% NaCMC), LS1 group (28.6 mg/kgbw), LS2 group (57.2 mg/kgbw), LS3 group (114.4 mg/kgbw), and LS4 group (228.8 mg/kgbw). The Lansau extract was given through a single oral route and then the behavior and motoric activity of rats were observed from days 0-14. The results show that no animals died until 14-day of all dosage groups; thus, the LD50 (Lethal dose 50) value could not be concluded yet. Observation of behavior and motoric activity shows some decrease in the activity of rats (grooming, looking up and down, hanging, urinating, defying, etc.). Histopathological data of the lungs show that the lungs were still normal while histopathological data of the liver show necrosis in the LS4 group. The histopathological data of the kidney show normal conditions.Keywords: Acute Toxicity Test, Lansau, LD50.ABSTRAKLansau adalah ramuan obat tradisional khas suku Muna yang terdiri dari 44 jenis tanaman obat. Penggunaan Lansau dimasyarakat Muna secara empiris mampu mengatasi berbagai penyakit degeneratif seperti Diabetes Militus, Hipertensi, Perbaikan fungsi Ginjal dan penyakit degeneratif lainnya. Untuk mengetahui keamaman penggunaan ramuan obat Lansau maka dilakukan uji toksisitas akut ekstrak etanol ramuan obat Lansau melalui perhitungan nilai LD50 (Lethal dose 50) dan pengamatan histopatologi organ paru-paru, hati dan ginjal tikus putih jantan galur wistar. Tikus jantan wistar yang digunakan berjumlah 25 ekor yang terbagi menjadi 5 kelompok yaitu kelompok KN (NaCMC 0,5%), kelompok LS 1 (28,6 mg/kgbb), kelompok LS 2 (57,2 mg/kgbb), kelompok LS 3 (114,4 mg/kgbb) dan kelompok LS 4 ( 228,8 mg/kgbb ). Pemberian sediaan ekstrak etanol Lansau diberikan melalui rute peroral dengan dosis tunggal kemudian diamati Perilaku dan aktivitas motorik tikus dari hari 0-14. Hasil penelitian menunjukan tidak ada hewan yang mati hingga hari ke-14 dari semua kelompok dosis sehingga nilai LD50 (Lethal dose 50) belum dapat disimpulkan. Pengamatan perilaku dan aktivitas motorik menunujukan beberapa penurunan respon keaktifan tikus (Grooming, menengok atas dan bawah, menggantung, urinasi, defikasi dan lain-lain). Data hasil histopatologi organ paru-paru menunjukan organ paru-paru masih normal, data histopatologi organ hati menunjukan terjadinya nekrosis pada kelompok LS 4, data hitopatologi organ ginjal menunjukan keadaan normal.Keyword: Lansau, LD50,Uji Toksisitas Akut</dc:description>
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	<dc:date>2020-07-26</dc:date>
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	<dc:source xml:lang="en-US">Jurnal Sains dan Teknologi Pangan; Vol 5, No 3 (2020): Jurnal Sains dan Teknologi Pangan</dc:source>
	<dc:source>2527-6271</dc:source>
	<dc:source>10.33772/jstp.v5i3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ojs.uho.ac.id/index.php/jstp/article/view/13114/9095</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Jurnal Sains dan Teknologi Pangan</dc:rights>
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