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Analisis Pertumbuhan Kartilago Epifisialis Os Tibia Fetus Mencit (Mus musculus L.) Swiss Webster Setelah Induksi Ochratoxin A Selama Periode Organogenesis

JURNAL BIOLOGI PAPUA · Vol. 4 No. 1 (2018) · hlm. 25–31

DOI
10.31957/jbp.532
ISSN
2503-0450, 2086-3314
Terbit
2018-10-14
Penerbit
Jurusan Biologi FMIPA Universitas Cenderawasih
Bahasa
eng

Abstrak

The aims of this study were determined the effects of Ochratoxin A (OTA) on growth of fetus tibia epiphyseal cartilage during organogenesis period. Twenty four pregnant mice were divided randomly into 4 groups of 6. Ochratoxin A was dissolved in sodium bicarbonateand administered orally on seventh to fourteenth days of gestation at dosage of 0.5, 1.0, 1.5 mg/kg bw, respectively. The remaining were used as control. The fetal tibia was taken after the 18 th day of pregnancy. The growth of tibia epiphyseal cartilages were observed histologically using Erlich’s Haematoxylin-Eosin Stain. The result of this study indicated that OTA caused decreased thickness of the rest zone, proliferative zone, maturation zone and calsification zone of the fetus tibial growth plate significantly. Key words: Ochratoxin A, tibia, cartilage, and thickness.

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  • Universitas Gadjah Mada
  • Sriwijaya University
  • Sebelas Maret University
  • IPB University
  • Muhammadiyah University of Yogyakarta
  • Universitas Airlangga
  • Riau University
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Rekan penulisOrganisasiArtikel bersama
Michael Haryadi WibowoUniversitas Gadjah Mada4
Wayan Tunas ArtamaUniversitas Gadjah Mada4
Laila HanumSriwijaya University3
Marsetyawan H. N. E. SoesatyoUniversitas Gadjah Mada2
Indra YustianSriwijaya University2
Triyanto TriyantoUniversitas Gadjah Mada2
Nursyirwani NursyirwaniRiau University2
A. E. T. H. WahyuniUniversitas Gadjah Mada2
Jaka WidadaUniversitas Gadjah Mada2
Alimuddin AlimuddinIPB University2
Sebastian MarginoUniversitas Gadjah Mada2
Widodo WidodoIPB University2
Sri DarmawatiUniversitas Muhammadiyah Semarang2
Langkah SembiringUniversitas Gadjah Mada2
Tri UntariAfiliasi tidak diketahui2
Elfita ElfitaSriwijaya University2
Pinandi Sri PudyaniUniversitas Gadjah Mada1
Ika Dewi AnaUniversitas Gadjah Mada1
Tita Ratya UtariMuhammadiyah University of Yogyakarta1
Siti SunarintyasUniversitas Gadjah Mada1
Juni HandajaniUniversitas Gadjah Mada1
Yulita KristantiUniversitas Gadjah Mada1
Risya CilmiatySebelas Maret University1
Mandojo RukmoUniversitas Airlangga1
Afiono Agung PrasetyoSebelas Maret University1
Khilyat Ulin Nur ZainiSebelas Maret University1
Suhartono Taat PutraUniversitas Airlangga1
Banun KusumawardaniUniversitas Jember1
Djaswadi DasukiUniversitas Gadjah Mada1
Al Supartinah SantosoUniversitas Gadjah Mada1
Regina TC. TandelilinUniversitas Gadjah Mada1
Abdul Salam M. SofroYarsi University1
Widjijono WidjijonoUniversitas Gadjah Mada1
Nuryono NuryonoUniversitas Gadjah Mada1
Dwi Aji NugrohoMuhammadiyah University of Yogyakarta1
Wijayanti Dwi AastutiUniversitas Gadjah Mada1

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Sumber metadata: OAI-PMH (metadata jurnal) https://ejournal.uncen.ac.id/index.php/JBP/oai, pertama di-harvest 1 Nov 2026, terakhir terlihat 8 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Analisis Pertumbuhan Kartilago Epifisialis Os Tibia Fetus Mencit (Mus musculus L.) Swiss Webster Setelah Induksi Ochratoxin A Selama Periode Organogenesis</dc:title>
	<dc:creator>Setiawan, Arum</dc:creator>
	<dc:creator>Sagi, Mammed</dc:creator>
	<dc:creator>Asmara, Widya</dc:creator>
	<dc:creator>Istriyati, Istriyati</dc:creator>
	<dc:description xml:lang="en-US">The aims of this study were determined the effects of Ochratoxin A (OTA) on growth of fetus tibia epiphyseal cartilage during organogenesis period. Twenty four pregnant mice were divided randomly into 4 groups of 6. Ochratoxin A was dissolved in sodium bicarbonateand administered orally on seventh to fourteenth days of gestation at dosage of 0.5, 1.0, 1.5 mg/kg bw, respectively. The remaining were used as control. The fetal tibia was taken after the 18 th day of pregnancy. The growth of tibia epiphyseal cartilages were observed histologically using Erlich’s Haematoxylin-Eosin Stain. The result of this study indicated that OTA caused decreased thickness of the rest zone, proliferative zone, maturation zone and calsification zone of the fetus tibial growth plate significantly. Key words: Ochratoxin A, tibia, cartilage, and thickness.</dc:description>
	<dc:publisher xml:lang="en-US">Jurusan Biologi FMIPA Universitas Cenderawasih</dc:publisher>
	<dc:date>2018-10-14</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ejournal.uncen.ac.id/index.php/JBP/article/view/532</dc:identifier>
	<dc:identifier>10.31957/jbp.532</dc:identifier>
	<dc:source xml:lang="en-US">JURNAL BIOLOGI PAPUA; Vol. 4 No. 1 (2012); 25-31</dc:source>
	<dc:source xml:lang="id-ID">Jurnal Biologi Papua; Vol 4 No 1 (2012); 25-31</dc:source>
	<dc:source>2503-0450</dc:source>
	<dc:source>2086-3314</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ejournal.uncen.ac.id/index.php/JBP/article/view/532/468</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 JURNAL BIOLOGI PAPUA</dc:rights>
</oai_dc:dc>