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In vivo study of antipyretic activity of Sampare leaf extract (Glochidion sp.) from Biak-Numfor Regency

JURNAL BIOLOGI PAPUA · Vol. 18 No. 1 (2026) · pp. 29–36

DOI
10.31957/jbp.5239
ISSN
2503-0450, 2086-3314
Published
2026-04-01
Publisher
Jurusan Biologi FMIPA Universitas Cenderawasih
Language
eng

Abstract

The local people of Biak Regency use the Sampare Leaf (Glochidion sp.) to cure malaria and reliefe fever. This plant contains flavonoid compounds, alkaloids, saponins, and tannins that can act as antipyretics. This study aims to determine the antipyretic activity and the most effective dosage of Sampare leaf extract as an antipyretic. The research method was a laboratory experimental. The antipyretic testing method used is peptone-induced fever. A total of 30 mice were divided into 6 treatment groups. The inducing solution, peptone, is induced subcutaneously, and the test solution is administered orally. The results showed that Sampare leaf extract had a percent antipyretic power, namely at 150mg/kgBW of 30.17%, a dose of 200mg/kgBW of 49.66%, and a dose of 250mg/kgBW of 70.80%. The ANOVA test showed that the 250mg/kgBW extract treatment group and the 200mg/kgBW dose with the positive control group has no significant difference, so it can be concluded that the 250mg/kgBW extract dose is an effective dose that provides a good antipyretic effect.

Collaboration network of the authors

16 authors · 43 co-authorship links

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Co-authorOrganisationJoint articles
Claudius H.B. TobiAffiliation unknown3
Kevry SupraptiAffiliation unknown3
Andre A. BarusAffiliation unknown3
Elsye GunawanAffiliation unknown2
Rusnaeni RusnaeniAffiliation unknown1
Aris A.L. ToruanAffiliation unknown1
Rani D. PratiwiAffiliation unknown1
Maria J.S OlaAffiliation unknown1
RusnaeniAffiliation unknown1
Sarce M. SasarariAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://ejournal.uncen.ac.id/index.php/JBP/oai, first harvested 1 Nov 2026, last seen 1 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en-US">In vivo study of antipyretic activity of Sampare leaf extract (Glochidion sp.) from Biak-Numfor Regency</dc:title>
	<dc:creator>Bakri, Nur F.</dc:creator>
	<dc:creator>Simanjuntak, Artha M.</dc:creator>
	<dc:creator>Pratiwi, Mustika E.</dc:creator>
	<dc:creator>Jedaut, Agatha C.I.</dc:creator>
	<dc:creator>Pasaribu, Napita P.C.</dc:creator>
	<dc:creator>Appa, Felycitae E.</dc:creator>
	<dc:description xml:lang="en-US">The local people of Biak Regency use the Sampare Leaf (Glochidion sp.) to cure malaria and reliefe fever. This plant contains flavonoid compounds, alkaloids, saponins, and tannins that can act as antipyretics. This study aims to determine the antipyretic activity and the most effective dosage of Sampare leaf extract as an antipyretic. The research method was a laboratory experimental. The antipyretic testing method used is peptone-induced fever. A total of 30 mice were divided into 6 treatment groups. The inducing solution, peptone, is induced subcutaneously, and the test solution is administered orally. The results showed that Sampare leaf extract had a percent antipyretic power, namely at 150mg/kgBW of 30.17%, a dose of 200mg/kgBW of 49.66%, and a dose of 250mg/kgBW of 70.80%. The ANOVA test showed that the 250mg/kgBW extract treatment group and the 200mg/kgBW dose with the positive control group has no significant difference, so it can be concluded that the 250mg/kgBW extract dose is an effective dose that provides a good antipyretic effect.</dc:description>
	<dc:publisher xml:lang="en-US">Jurusan Biologi FMIPA Universitas Cenderawasih</dc:publisher>
	<dc:date>2026-04-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://ejournal.uncen.ac.id/index.php/JBP/article/view/5239</dc:identifier>
	<dc:identifier>10.31957/jbp.5239</dc:identifier>
	<dc:source xml:lang="en-US">JURNAL BIOLOGI PAPUA; Vol. 18 No. 1 (2026); 29-36</dc:source>
	<dc:source xml:lang="id-ID">Jurnal Biologi Papua; Vol 18 No 1 (2026); 29-36</dc:source>
	<dc:source>2503-0450</dc:source>
	<dc:source>2086-3314</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://ejournal.uncen.ac.id/index.php/JBP/article/view/5239/3628</dc:relation>
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