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Piper Crocatum Ruiz and Pav as A Commonly Used Typically Medicinal Plant From Indonesia: What Do We Actually Know About It? Scoping Review

Indonesian Contemporary Nursing Journal (ICON Journal) · Vol. 7 No. 2 (2023) · pp. 61–78

DOI
10.20956/icon.v7i2.23891
ISSN
2686-116X, 2528-2557
Published
2023-02-28
Publisher
Faculty of Nursing, Universitas Hasanuddin
Language
en

Abstract

Aims: Piper crocatum Ruiz & Pav (P. crocatum) has been widely used medicinally among ethnic communities in Indonesia to treat a variety of diseases through various preparation- application techniques, duration, and frequency of use. Since research on the benefits of P. crocatum is still limited, our scoping review aimed to identify the key findings resulting from experimental studies regarding the medicinal uses of P. crocatum. Methods: We conducted a scoping review using the framework developed by Arksey and O’Malley. Databases were searched using CAB Direct, ProQuest, ScienceDirect, SpringerLink, and Google Scholar. Data were extracted and tabulated using Microsoft Office Excel 2013. Results: Sixteen articles fulfilled were included in the scoping review. Three key concepts were emerged from this scoping review: 1) Study characteristics indicated the most prevalent type of research was in vivo experiment (n=14) with the highest number of preparations using ethanol extracts (n=8) and P. crocatum sample were mostly sourced from Indonesia (n=9); 2) Seventeen screened metabolites were reported and the most frequently identified were steroids and flavonoids, followed by polyphenols and saponins; and 3) Eight potential activities of P. crocatum were reported as follows: anti-inflammatory, pro-wound healing, antibacterial, antioxidant, anti-necrotic, antitumoral, hepatoprotective, and anti-hyperglycaemic. Conclusion: P. crocatum has various metabolites that might influence the reported potential therapeutic activities with different preparation-application techniques, uses, and duration, yet the scientific evidence conducted in clinical study is still limited. Future research needs to perform testing standardized preparations of P. crocatum to be developed as novel therapeutic agents in wounds, infective diseases, cancers, diabetes, and liver diseases.

Keywords

Collaboration network of the authors

15 authors · 34 co-authorship links · 5 across different organisations

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Islamic University of Indonesia
  • Universitas Gadjah Mada
  • Institut Teknologi Telkom Purwokerto
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Ridho RahmadiIslamic University of Indonesia3
Moh. Syafar SangkalaAffiliation unknown2
Yuan Sa'adatiIslamic University of Indonesia1
Rizki Surtiyan SuryaIslamic University of Indonesia1
Yohani Setiya Rafika NurInstitut Teknologi Telkom Purwokerto1
Satrial MudatsirAffiliation unknown1
Nur FadilahUniversitas Gadjah Mada1
Andi WahyuniAffiliation unknown1
Silvia MalasariAffiliation unknown1
Nuurhidayat JafarAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/icon/oai, first harvested 2 Nov 2026, last seen 2 Nov 2026.
Original metadata (oai_dc)
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	<dc:title xml:lang="en">Piper Crocatum Ruiz and Pav as A Commonly  Used Typically Medicinal Plant From Indonesia:  What Do We Actually Know About It? Scoping  Review</dc:title>
	<dc:creator xml:lang="en">Setyawati, Andina</dc:creator>
	<dc:creator xml:lang="en">Wahyuningsih, Mae Sri Hartati</dc:creator>
	<dc:creator xml:lang="en">Nugrahaningsih, Dwi Aris Agung</dc:creator>
	<dc:creator xml:lang="en">Effendy, Christantie</dc:creator>
	<dc:creator xml:lang="en">Ibeneme, Sam</dc:creator>
	<dc:subject xml:lang="en">Piper crocatum</dc:subject>
	<dc:subject xml:lang="en">medicinal plant</dc:subject>
	<dc:subject xml:lang="en">potential activity</dc:subject>
	<dc:subject xml:lang="en">metabolite</dc:subject>
	<dc:subject xml:lang="en">scoping review</dc:subject>
	<dc:description xml:lang="en">Aims: Piper crocatum Ruiz &amp;amp; Pav (P. crocatum) has been widely used medicinally among ethnic communities in Indonesia to treat a variety of diseases through various preparation- application techniques, duration, and frequency of use. Since research on the benefits of P. crocatum is still limited, our scoping review aimed to identify the key findings resulting from experimental studies regarding the medicinal uses of P. crocatum.
Methods: We conducted a scoping review using the framework developed by Arksey and O’Malley. Databases were searched using CAB Direct, ProQuest, ScienceDirect, SpringerLink, and Google Scholar. Data were extracted and tabulated using Microsoft Office Excel 2013.
Results: Sixteen articles fulfilled were included in the scoping review. Three key concepts were emerged from this scoping review: 1) Study characteristics indicated the most prevalent type of research was in vivo experiment (n=14) with the highest number of preparations using ethanol extracts (n=8) and P. crocatum sample were mostly sourced from Indonesia (n=9); 2) Seventeen screened metabolites were reported and the most frequently identified were steroids and flavonoids, followed by polyphenols and saponins; and 3) Eight potential activities of P. crocatum were reported as follows: anti-inflammatory, pro-wound healing, antibacterial, antioxidant, anti-necrotic, antitumoral, hepatoprotective, and anti-hyperglycaemic.
Conclusion: P. crocatum has various metabolites that might influence the reported potential therapeutic activities with different preparation-application techniques, uses, and duration, yet the scientific evidence conducted in clinical study is still limited. Future research needs to perform testing standardized preparations of P. crocatum to be developed as novel therapeutic agents in wounds, infective diseases, cancers, diabetes, and liver diseases.</dc:description>
	<dc:publisher xml:lang="en">Faculty of Nursing, Universitas Hasanuddin</dc:publisher>
	<dc:date>2023-02-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewer Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/icon/article/view/23891</dc:identifier>
	<dc:identifier>10.20956/icon.v7i2.23891</dc:identifier>
	<dc:source xml:lang="en">Indonesian Contemporary Nursing Journal (ICON Journal); Vol. 7 No. 2 (2023): Volume 7 No. 2 Februari 2023 ; 61-78</dc:source>
	<dc:source>2686-116X</dc:source>
	<dc:source>2528-2557</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/icon/article/view/23891/9364</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2023 Indonesian Contemporary Nursing Journal </dc:rights>
</oai_dc:dc>