Jurnal
Follicular Development of Aged Rats Ovarian Injected Human Umbilical Cord Mesenchymal Stem Cells
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) · Vol. UME No. 1 (2020)
- ISSN
- 2615-2835, 2614-0187
- Published
- 2020-02-16
- Publisher
- Hasanuddin University
- Language
- en
Abstract
Female reproductive system showing the fastest signs of aging. The ovarian aging characterized by a decrease in follicular development. Stem cells are undifferentiated cells and can form a variety of different cells as the foundation of tissues and organs. Previous studies reported that Bone Marrow Mesenchymal Stem Cells (BM-MSCs) transplantation can restore follicular development in damaged ovarian rats. This study aimed to analyze the number of follicular development in aged rats and to analyze the capability of human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) to improving follicular development in aged rats. This study used 3 mature rats (4 months old), and 9 nine aged rats (22-24 months old), Spraque Dawley (SD) strain. They were divided into four groups. The first and the second group was mature rats and aged rats without injection. The third and the fourth group was aged rats injected hUC-MSCs dose 106 cells/kgBW and hUC-MSCs dose 107 cells/kgBW. The injection carried out 4 times at 3-month intervals. The parameters observed were follicular development and homing image of hUC-MSCs in ovarian tissue. The results showed that the number of follicular developments in aged rats 22-24 months decreased significantly compared to mature rats 4 months old. Injection of hUC-MSCs at dose 106 cells/kgBW and 107 cells/kgBW did not increase follicular development in aged rats. hUC-MSCs did not found in ovarian tissue. It could be concluded that aged rats 22-24 months old no longer productive indicated from the number of follicular developments and corpus luteum decreased. The injection of hUC-MSCs intravenously did not indicate an improvement of follicular development in aged rats 22-24 months old.
Keywords
Collaboration network of the authors
28 authors · 126 co-authorship links
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- IPB University
- Universitas Halu Oleo
- Affiliation unknown
- Different organisations
- Same organisation
- Affiliation unknown
- Thicker line = more joint articles · bigger circle = more articles
Show as table
| Co-author | Organisation | Joint articles |
|---|---|---|
| Niken Ulupi | IPB University | 2 |
| Hera Maheshwari | Affiliation unknown | 2 |
| Desrayni Hanadhita | Affiliation unknown | 2 |
| La Jumadin | Affiliation unknown | 1 |
| NUR ISNAINI ULFA | Universitas Halu Oleo | 1 |
| Savitri Novelina | Affiliation unknown | 1 |
| Muhammad Ardiansyah Nurdin | Affiliation unknown | 1 |
| Agik Suprayogi | Affiliation unknown | 1 |
| Huda Salahuddin Darusman | Affiliation unknown | 1 |
| Srihadi Agungpriyono | Affiliation unknown | 1 |
| Koekoeh Santoso | Affiliation unknown | 1 |
| Yulvian Sani | Affiliation unknown | 1 |
| Elok Budi Retnani | Affiliation unknown | 1 |
| Jefri Naldi | Affiliation unknown | 1 |
| Irwan Oktoni | Affiliation unknown | 1 |
| David Anwar | Affiliation unknown | 1 |
| Ainul Khadija Saleema | Affiliation unknown | 1 |
Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.