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The Effect of Ajwa Dates Fruit Extract (Phoenix dactylifera L.) on the Creatinine Levels in White Rats (Rattus norvegicus) Induced by Meloxicam Toxic Doses

Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) · Vol. UME No. 2 (2022)

ISSN
2615-2835, 2614-0187
Published
2022-07-28
Publisher
Hasanuddin University
Language
en
License
creativecommons.org/licenses/by-nc/4.0

Abstract

Meloxicam is an NSAID (non-steroidal anti-inflammatory drug) which is an antipyretic analgesic drug as well as a non-steroidal anti-inflammatory drug that is widely used by the public, including pet owners, in treating their favorite animals without advice from a veterinarian. The use of meloxicam in excessive doses can trigger kidney damage. Based on related research, meloxicam can cause cell death due to nephrotoxicity. Ajwa dates have the highest antioxidant activity among other types of dates, suppress lipid peroxidation, prevent cell damage, and have nephroprotective abilities. The aim of this study was to determine the effect of giving ajwa date fruit extract on creatinine levels of male wistar rats induced by toxic dose of meloxicam. This research is an experimental research with the research design used is the Pre Test-Post Test Design Group. The total sample used was 24 male wistar rats which were divided into 4 groups, namely the negative control group (K1) which was given 1% Na CMC on days 1-18, the positive control group (K2) which was given meloxicam 30mg/kgBW on day 1- 4 and 1% Na CMC on days 5-18, treatment group 1 (K3) was given meloxicam 30mg/kgBW on days 1-4 and ajwa date fruit extract 150mg/kgBW on days 5-18, treatment group 2 (K4) given meloxicam 30 mg/kg body weight on days 1-4 and ajwa date fruit extract 300 mg/kg body weight on days 5-18. Blood sampling was carried out on day 19 to measure creatinine levels. The results of data analysis using the Independent T-Test test for groups K1 and K2 were P < 0.05, which means that there is a statistically significant relationship between the administration of meloxicam and the increase in creatinine levels. The results of data analysis using the independent T-Test test for the K2 group with K3 and K4 were P<0.05, which means that there is a statistically significant relationship between the administration of ajwa date fruit extract and the decrease in creatinine levels of rats given a toxic dose of meloxicam. Keywords: Ajwa dates, creatinine, meloxicam, nephroprotective, white rat

Collaboration network of the authors

40 authors · 126 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • Affiliation unknown
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  • Same organisation
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Co-authorOrganisationJoint articles
MusdalifahAffiliation unknown4
Waode Santa MonicaAffiliation unknown3
Dwi Kesuma SariAffiliation unknown2
Zulfikri MustakdirAffiliation unknown2
Muhammad Zulfadillah SinusiAffiliation unknown2
Elphan Augusta KajangAffiliation unknown2
Nurul IdhayaniAffiliation unknown1
Fahria Nadiryati SadimantaraUniversitas Halu Oleo1
Surni SurniAffiliation unknown1
Yona Wahyu LolitaAffiliation unknown1
Syahrul IbadAffiliation unknown1
Alif GunawanAffiliation unknown1
Ummu Kalzum BakhtiarAffiliation unknown1
Izza Amalia HamzarAffiliation unknown1
Muh. NurllhamAffiliation unknown1
Nur Muzhaffarah Fhathana SapriadiAffiliation unknown1
Nurul Afni SaskiaAffiliation unknown1
Andi Kirey Ananda Regita RamliAffiliation unknown1
Inggit NurvadillaAffiliation unknown1
Niswa AtaliaAffiliation unknown1
Muhammad KurniaAffiliation unknown1
Sumarlin RengkoAffiliation unknown1
Anwar DaudAffiliation unknown1
Agus Bintara BirawidaAffiliation unknown1
Indah Windy OctaviyaniAffiliation unknown1
Ferbian Milas SiswantoAffiliation unknown1
Boedi Prihatini YenniastoetiAffiliation unknown1
Alex PangkahilaAffiliation unknown1
Irfan IdrisAffiliation unknown1
Meriam SirupangAffiliation unknown1
Abdul Wahid JamaluddinAffiliation unknown1
Carisma SumuleAffiliation unknown1
Ainun RarasmikaAffiliation unknown1
Nurul Sulfi AndiniAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jrvi/oai, first harvested 3 Nov 2026, last seen 3 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">The Effect of Ajwa Dates Fruit Extract (Phoenix dactylifera L.) on the Creatinine Levels in White Rats (Rattus norvegicus) Induced by Meloxicam Toxic Doses</dc:title>
	<dc:creator xml:lang="en">Suparmin, Yuliani</dc:creator>
	<dc:creator xml:lang="en">Risha Catra Pradhany</dc:creator>
	<dc:creator xml:lang="en">Musdalifah, Musdalifah</dc:creator>
	<dc:creator xml:lang="en">Fatmawati, Dian</dc:creator>
	<dc:creator xml:lang="en">Zainuddin, Nur Afzah</dc:creator>
	<dc:creator xml:lang="en">Nurdiana, Eka</dc:creator>
	<dc:description xml:lang="en">Meloxicam is an NSAID (non-steroidal anti-inflammatory drug) which is an antipyretic analgesic drug as well as a non-steroidal anti-inflammatory drug that is widely used by the public, including pet owners, in treating their favorite animals without advice from a veterinarian. The use of meloxicam in excessive doses can trigger kidney damage. Based on related research, meloxicam can cause cell death due to nephrotoxicity. Ajwa dates have the highest antioxidant activity among other types of dates, suppress lipid peroxidation, prevent cell damage, and have nephroprotective abilities. The aim of this study was to determine the effect of giving ajwa date fruit extract on creatinine levels of male wistar rats induced by toxic dose of meloxicam. This research is an experimental research with the research design used is the Pre Test-Post Test Design Group. The total sample used was 24 male wistar rats which were divided into 4 groups, namely the negative control group (K1) which was given 1% Na CMC on days 1-18, the positive control group (K2) which was given meloxicam 30mg/kgBW on day 1- 4 and 1% Na CMC on days 5-18, treatment group 1 (K3) was given meloxicam 30mg/kgBW on days 1-4 and ajwa date fruit extract 150mg/kgBW on days 5-18, treatment group 2 (K4) given meloxicam 30 mg/kg body weight on days 1-4 and ajwa date fruit extract 300 mg/kg body weight on days 5-18. Blood sampling was carried out on day 19 to measure creatinine levels. The results of data analysis using the Independent T-Test test for groups K1 and K2 were P &amp;lt; 0.05, which means that there is a statistically significant relationship between the administration of meloxicam and the increase in creatinine levels. The results of data analysis using the independent T-Test test for the K2 group with K3 and K4 were P&amp;lt;0.05, which means that there is a statistically significant relationship between the administration of ajwa date fruit extract and the decrease in creatinine levels of rats given a toxic dose of meloxicam.
&amp;nbsp;
Keywords: Ajwa dates, creatinine, meloxicam, nephroprotective, white rat</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2022-07-28</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jrvi/article/view/18666</dc:identifier>
	<dc:source xml:lang="en">Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research); VOLUME 6 No 2, JULY 2022</dc:source>
	<dc:source>2615-2835</dc:source>
	<dc:source>2614-0187</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jrvi/article/view/18666/8472</dc:relation>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by-nc/4.0</dc:rights>
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