Melola Discovery

← Melola Discovery

Open access Jurnal

Pathogenicity and Classification of Influenza A Virus in poultry isolates from Sulawesi in 2018

Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) · Vol. UME No. 2 (2023)

DOI
10.20956/jrvi.v7i2.22039
ISSN
2615-2835, 2614-0187
Published
2023-07-31
Publisher
Hasanuddin University
Language
en
License
creativecommons.org/licenses/by-nc/4.0

Abstract

Avian influenza (AI) is a viral infection caused by the Influenza virus type A. Infection with the Avian Influenza Virus (AIV) has resulted in major financial losses in the cattle industry as well as substantial public health consequences. Indonesia has been dealing with an HPAI H5N1 outbreak since 2003. Despite the implementation of many prevention and control measures, the AIV disease continues to spread. Three Sulawesi isolates were submitted to whole-genome sequencing (WGS) in 2018 using the Illumina next generation sequencing (NGS) technology. The BioEdit 7 molecular analysis application was used to do multiple alignments and amino acid prediction. The Influenza Research Database's Highly Pathogenic H5N1 Clade Classification Tool (https://www.fludb.org) was used for clade analysis. One of the virus's pathogenicity is the amino acid cleavage site in the hemagglutinin (HA) gene. We concluded that the PQRERRRK-GLF amino acid motif was present in the cleavage site of the HA gene in avian AIV isolates from Sulawesi in 2018. This indicates that the AIV virus isolates are pathogenic and highly virulent avian influenza viruses (HPAI). Clade analysis revealed that the AIV isolates were from the H5N1 virus clade 2.3.2.1c.

Collaboration network of the authors

20 authors · 72 co-authorship links

Hover or tap a name to highlight its co-authors. Double-click to open the author's page.

  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Dwi Kesuma SariAffiliation unknown3
RatnaAffiliation unknown3
SupriAffiliation unknown3
SuantiAffiliation unknown3
Ferra IndrawatiAffiliation unknown3
Adyatma Muhammad NurAffiliation unknown3
Muhammad Nasrum MassiAffiliation unknown3
Ratmawati MalakaAffiliation unknown1
Isnaniah BagendaAffiliation unknown1
Syarifah Nurul WaqiahAffiliation unknown1
Sadam Suliman Mohamed YousofAffiliation unknown1
Muhammad Ridha AlhamdaniAffiliation unknown1
Muhammad NurhamsyahAffiliation unknown1
Syaiful MuazirAffiliation unknown1
MustikawatiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jrvi/oai, first harvested 3 Nov 2026, last seen 3 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Pathogenicity and Classification of Influenza A Virus in poultry isolates from Sulawesi in 2018</dc:title>
	<dc:creator xml:lang="en">Mutisari, Dewi</dc:creator>
	<dc:creator xml:lang="en">Muflihanah</dc:creator>
	<dc:creator xml:lang="en">Ferra Hendrawati</dc:creator>
	<dc:creator xml:lang="en">Lestari</dc:creator>
	<dc:creator xml:lang="en">Hendra Wibawa</dc:creator>
	<dc:description xml:lang="en">Avian influenza (AI) is a viral infection caused by the Influenza virus type A. Infection with the Avian Influenza Virus (AIV) has resulted in major financial losses in the cattle industry as well as substantial public health consequences. Indonesia has been dealing with an HPAI H5N1 outbreak since 2003. Despite the implementation of many prevention and control measures, the AIV disease continues to spread. Three Sulawesi isolates were submitted to whole-genome sequencing (WGS) in 2018 using the Illumina next generation sequencing (NGS) technology. The BioEdit 7 molecular analysis application was used to do multiple alignments and amino acid prediction. The Influenza Research Database's Highly Pathogenic H5N1 Clade Classification Tool (https://www.fludb.org) was used for clade analysis. One of the virus's pathogenicity is the amino acid cleavage site in the hemagglutinin (HA) gene. We concluded that the PQRERRRK-GLF amino acid motif was present in the cleavage site of the HA gene in avian AIV isolates from Sulawesi in 2018. This indicates that the AIV virus isolates are pathogenic and highly virulent avian influenza viruses (HPAI). Clade analysis revealed that the AIV isolates were from the H5N1 virus clade 2.3.2.1c.</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2023-07-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jrvi/article/view/22039</dc:identifier>
	<dc:identifier>10.20956/jrvi.v7i2.22039</dc:identifier>
	<dc:source xml:lang="en">Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research); VOLUME 7, No 2, JULY 2023</dc:source>
	<dc:source>2615-2835</dc:source>
	<dc:source>2614-0187</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jrvi/article/view/22039/10180</dc:relation>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by-nc/4.0</dc:rights>
</oai_dc:dc>