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The Effect of Tamarilo Katarrung (Chypomandra betaceae) Extract Changes on Histology Description of the Testis of White Rats (Rattus norvegicus l) Wistar Strains Induced by Gentamicin

Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) · Vol. UME No. 2 (2024)

DOI
10.20956/jrvi.v8i2.24105
ISSN
2615-2835, 2614-0187
Published
2024-12-10
Publisher
Hasanuddin University
Language
en
License
creativecommons.org/licenses/by-nc/4.0

Abstract

Gentamicin is an antibiotic from the aminoglycoside group that works by inhibiting protein synthesis but has side effects such as nephrotoxicity and ototoxicity and can induce oxidative stress in the testes. Oxidative stress is when the number of free radicals increases or the amount of antioxidants decreases. Oxidative stress induction in the testes has a degenerative effect on the testes, so the normal function and structure are disturbed. Dutch eggplant is one of the natural antioxidants that have the potential to protect cells from damage caused by oxidative stress. The utilization of this fruit extract has been proven to have secondary metabolic components in the form of phenols, flavonoids, anthocyanins, and carotenoids, which are antioxidants. This study aimed to examine the effect of tamarillo katarrung extract on the histology of the testes of gentamicin-induced Wistar rats. The research was conducted at the Integrated Laboratory of Animal Clinic Education, Hasanuddin University, Makassar. The sample used in this study amounted to 20 white rats of the Wistar strain, which were divided into four groups. The negative control group (K-) was untreated rats, and the positive control group (K+) was given gentamicin 20mg/kg BW induction for 11 days. The first treatment group (P1) was given tamarillo katarrung extract 200mg/kg BW for 14 days and gentamicin 20mg/kg BW for 11 days, while the second treatment (P2) was given tamarillo katarrung extract 200mg/kg BW for 14 days and gentamicin 20mg/kg BW for 11 days. The results showed a significant difference (p<0.05) between groups K+ and K-, P1 and P2. The histological description of the rat testes with the Johnson score shows that the tamarillo katarrung extract can defend testicular tissue from damage due to oxidative stress with the most optimal dose of 200 mg/kg BW. Keywords: tamarillo katarrung, antioxidant, gentamicin, rat

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17 authors · 63 co-authorship links

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Co-authorOrganisationJoint articles
Fika Yuliza PurbaAffiliation unknown1
Dwi Arini Ardat ArdatAffiliation unknown1
Kadek Dian Krisna PutriAffiliation unknown1
Eka ApriliaAffiliation unknown1
Naila Cahyani Kusuma Astuti SamodrAffiliation unknown1
Annisa IrianiAffiliation unknown1
Elphan AugustaAffiliation unknown1
Dwi Kesuma SariAffiliation unknown1
Nurul Sulfi AndiniAffiliation unknown1
Rini AmrianiAffiliation unknown1
Gilang Ramadhan GilangAffiliation unknown1
Muhammad Zoel Vitra Ramadhan K.Affiliation unknown1
Faiz Adlan AzzuhdiAffiliation unknown1
Nabila AzzahraAffiliation unknown1
NurlinaAffiliation unknown1
Putri Dyah ZahraniAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/jrvi/oai, first harvested 3 Nov 2026, last seen 3 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">The Effect of Tamarilo Katarrung (Chypomandra betaceae) Extract Changes on Histology Description of the Testis of White Rats (Rattus norvegicus l) Wistar Strains Induced by Gentamicin</dc:title>
	<dc:creator xml:lang="en">Bahmid, Nur Alif</dc:creator>
	<dc:description xml:lang="en">Gentamicin is an antibiotic from the aminoglycoside group that works by inhibiting protein synthesis but has side effects such as nephrotoxicity and ototoxicity and can induce oxidative stress in the testes. Oxidative stress is when the number of free radicals increases or the amount of antioxidants decreases. Oxidative stress induction in the testes has a degenerative effect on the testes, so the normal function and structure are disturbed. Dutch eggplant is one of the natural antioxidants that have the potential to protect cells from damage caused by oxidative stress. The utilization of this fruit extract has been proven to have secondary metabolic components in the form of phenols, flavonoids, anthocyanins, and carotenoids, which are antioxidants. This study aimed to examine the effect of tamarillo katarrung extract on the histology of the testes of gentamicin-induced Wistar rats. The research was conducted at the Integrated Laboratory of Animal Clinic Education, Hasanuddin University, Makassar. The sample used in this study amounted to 20 white rats of the Wistar strain, which were divided into four groups. The negative control group (K-) was untreated rats, and the positive control group (K+) was given gentamicin 20mg/kg BW induction for 11 days. The first treatment group (P1) was given tamarillo katarrung extract 200mg/kg BW for 14 days and gentamicin 20mg/kg BW for 11 days, while the second treatment (P2) was given tamarillo katarrung extract 200mg/kg BW for 14 days and gentamicin 20mg/kg BW for 11 days. The results showed a significant difference (p&amp;lt;0.05) between groups K+ and K-, P1 and P2. The histological description of the rat testes with the Johnson score shows that the tamarillo katarrung extract can defend testicular tissue from damage due to oxidative stress with the most optimal dose of 200 mg/kg BW.
Keywords: tamarillo katarrung, antioxidant, gentamicin, rat</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2024-12-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/jrvi/article/view/24105</dc:identifier>
	<dc:identifier>10.20956/jrvi.v8i2.24105</dc:identifier>
	<dc:source xml:lang="en">Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research); VOLUME 8 No. 2, JULY 2024</dc:source>
	<dc:source>2615-2835</dc:source>
	<dc:source>2614-0187</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/jrvi/article/view/24105/12244</dc:relation>
	<dc:rights xml:lang="en">http://creativecommons.org/licenses/by-nc/4.0</dc:rights>
</oai_dc:dc>