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Bioactivity of Nypa fruticans Leaves as A Candidate for Anticancer Compounds Against MCF-7 Breast Cancer Cells: Bioactivity of Nypa fruticans Leaves as A Candidate for Anticancer Compounds Against MCF-7 Breast Cancer Cells

International Journal of Applied Biology · Vol. 6 No. 1 (2022) · pp. 54–62

ISSN
2580-2119, 2580-2410
Published
2022-07-07
Publisher
Hasanuddin University
Language
en

Abstract

Breast cancer is the highest incidence of cancer for among women worldwide. The use of anticancer compounds from natural ingredients as cancer therapeutics is to reduce chemotherapy side effects. Indonesia has high biodiversity especially its pharmacologically beneficial such as Nipah. Nipah (Nypa fruticans W.) is a type of palm-shaped mangrove plant which widely found in watershed areas. This study aims to explores the bioactivity of ethanol extract from N. fruticans leaves against MCF-7 breast cancer cells. Screening for bioactive compounds was performed by Gas chromatography-mass spectrometry (GC-MS). Anticancer pre-screening was assessed by brine shrimp lethality (BSL) test and anticancer activity was assessed by 3-(4,5-Dimethylthiazol-2-cyl)-2,5-Diphenyltetrazolium Bromide (MTT) assay. According of GC-MS analysis showed the presence of 54 phytochemical compounds. Some of them have bioactivity as anticancer including Sitosterol, Tocopherol, and Phytol. The BSLT method showed potent activity with LC50 was 84.25 µg/mL. Anticancer activity using MTT assays results the low IC50 value was 88.77 µg/mL that showed high anticancer activity by growth inhibition in MCF-7 breast cancer cells. This study delivers information that ethanol extract from N. fruticans leaves possesses bioactive compounds could be use as a candidate for anticancer compounds for cancer treatment.

Keywords

Collaboration network of the authors

16 authors · 36 co-authorship links

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  • Universitas Sulawesi Tenggara
  • Affiliation unknown
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  • Same organisation
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Co-authorOrganisationJoint articles
Magdalena LitaayAffiliation unknown2
Rosana AgusAffiliation unknown2
Slamet SantosaAffiliation unknown2
Willem MokaAffiliation unknown2
Ulfah Nur AmaliahAffiliation unknown1
Munif S HasanAffiliation unknown1
Elis TambaruAffiliation unknown1
Syahribulan SyahribulanAffiliation unknown1
Nur Ramaliani SamsulAffiliation unknown1
Herwin HerwinUniversitas Sulawesi Tenggara1
Sjafaraenan SjafaraenanAffiliation unknown1
Jennyta Dhewi Darmansyah TanjungAffiliation unknown1
Jennyta Dhewi Darmansyah TanjungAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/ijoab/oai, first harvested 3 Nov 2026, last seen 3 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Bioactivity of Nypa fruticans Leaves as A Candidate for Anticancer Compounds Against MCF-7 Breast Cancer Cells: Bioactivity of Nypa fruticans Leaves as A Candidate for Anticancer Compounds Against MCF-7 Breast Cancer Cells</dc:title>
	<dc:creator xml:lang="en">Noviana, Evy Noviana</dc:creator>
	<dc:creator xml:lang="en">Johannes, Eva</dc:creator>
	<dc:creator xml:lang="en">Sjafaraenan</dc:creator>
	<dc:subject xml:lang="en">bioactive compounds</dc:subject>
	<dc:subject xml:lang="en">Nypa fruticans</dc:subject>
	<dc:subject xml:lang="en"> breast cancer,</dc:subject>
	<dc:subject xml:lang="en">MCF-7 cells</dc:subject>
	<dc:subject xml:lang="en">gas chromatography-mass spectrometry</dc:subject>
	<dc:description xml:lang="en">Breast cancer is the highest incidence of cancer for among women worldwide. The use of anticancer compounds from natural ingredients as cancer therapeutics is to reduce chemotherapy side effects. Indonesia has high biodiversity especially its pharmacologically beneficial such as Nipah. Nipah (Nypa fruticans W.) is a type of palm-shaped mangrove plant which widely found in watershed areas . This study aims to explores the bioactivity of ethanol extract from N. fruticans leaves against MCF-7 breast cancer cells. Screening for bioactive compounds was performed by Gas chromatography-mass spectrometry (GC-MS). Anticancer pre-screening was assessed by brine shrimp lethality (BSL) test and anticancer activity was assessed by 3-(4,5-Dimethylthiazol-2-cyl)-2,5-Diphenyltetrazolium Bromide (MTT) assay. According of GC-MS analysis showed the presence of 54 phytochemical compounds. Some of them have bioactivity as anticancer including Sitosterol, Tocopherol, and Phytol. The BSLT method showed potent activity with LC50 was 84.25 µg/mL. Anticancer activity using MTT assays results the low IC50 value was 88.77 µg/mL that showed high anticancer activity by growth inhibition in MCF-7 breast cancer cells. This study delivers information that ethanol extract from N. fruticans leaves possesses bioactive compounds could be use as a candidate for anticancer compounds for cancer treatment.</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2022-07-07</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/ijoab/article/view/19091</dc:identifier>
	<dc:source xml:lang="en">International Journal of Applied Biology; Vol. 6 No. 1 (2022): International Journal of Applied Biology; 54-62</dc:source>
	<dc:source>2580-2119</dc:source>
	<dc:source>2580-2410</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/ijoab/article/view/19091/8406</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2022 International Journal of Applied Biology</dc:rights>
</oai_dc:dc>