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In Silico Testing on the Activity of Quercetin in the Skin of Onion Allium Cepa L as A Natural Antihypertensive Compound

International Journal of Applied Biology · Vol. 6 No. 2 (2022) · pp. 172–178

ISSN
2580-2119, 2580-2410
Published
2022-12-29
Publisher
Hasanuddin University
Language
en

Abstract

This study aims to determine the bioactivity of the compound quercetin in the peel of Allium cepa L as a natural antihypertensive compound. The chemical structure of the quercetin compound found in Allium cepa L peel was taken from the literature. The target protein used was Angiotensin-Converting Enzyme (ACE), while the control compound was lisinopril. Water molecules were removed using PyMol v2.5.2 Software. Docking between the target protein and the compound was carried out using PyRx-Python Prescription 0.8 Software. The results showed that the quercetin compound had more significant potential as an antihypertensive compared to lisinopril as a control compound. The affinity ratio of the Angiotensin-converting enzyme with quercetin is -8.1, while the affinity value of the Angiotensin-converting enzyme with lisinopril is -7.1.

Keywords

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8 authors · 19 co-authorship links

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Co-authorOrganisationJoint articles
Ika YustisiaAffiliation unknown2
Nindrahayu SyamAffiliation unknown2
YusfinaAffiliation unknown2

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/ijoab/oai, first harvested 3 Nov 2026, last seen 3 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">In Silico Testing on the Activity of Quercetin in the Skin of Onion Allium Cepa  L as A Natural Antihypertensive Compound </dc:title>
	<dc:creator xml:lang="en">Ariyandy, Andi</dc:creator>
	<dc:creator xml:lang="en">Nindrahayu</dc:creator>
	<dc:creator xml:lang="en">Ami Febriza</dc:creator>
	<dc:creator xml:lang="en">Andi Irwan Muluk</dc:creator>
	<dc:creator xml:lang="en">Sulfahri</dc:creator>
	<dc:subject xml:lang="en">Quercetin</dc:subject>
	<dc:subject xml:lang="en">Angiotensin-Converting Enzyme (ACE)</dc:subject>
	<dc:subject xml:lang="en">Allium Cepa L</dc:subject>
	<dc:description xml:lang="en">This study aims to determine the bioactivity of the compound quercetin in the peel of Allium cepa L as a natural antihypertensive compound. The chemical structure of the quercetin compound found in Allium cepa L peel was taken from the literature. The target protein used was Angiotensin-Converting Enzyme (ACE), while the control compound was lisinopril. Water molecules were removed using PyMol v2.5.2 Software. Docking between the target protein and the compound was carried out using PyRx-Python Prescription 0.8 Software. The results showed that the quercetin compound had more significant potential as an antihypertensive compared to lisinopril as a control compound. The affinity ratio of the Angiotensin-converting enzyme with quercetin is -8.1, while the affinity value of the Angiotensin-converting enzyme with lisinopril is -7.1.</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2022-12-29</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/ijoab/article/view/22143</dc:identifier>
	<dc:source xml:lang="en">International Journal of Applied Biology; Vol. 6 No. 2 (2022): International Journal of Applied Biology; 172-178</dc:source>
	<dc:source>2580-2119</dc:source>
	<dc:source>2580-2410</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/ijoab/article/view/22143/9170</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2022 International Journal of Applied Biology</dc:rights>
</oai_dc:dc>