Antidiabetic Activity of Catechin from Cinnamon (Cinnamomun Burmanii) by Inhibiting Alfa Glucosidase Enzyme

Zaenab, St; Hasyim, Zohrah

Jurnal

Antidiabetic Activity of Catechin from Cinnamon (Cinnamomun Burmanii) by Inhibiting Alfa Glucosidase Enzyme

International Journal of Applied Biology · Vol. 6 No. 2 (2022) · pp. 242–248

ISSN: 2580-2119, 2580-2410
Published: 2022-12-29
Publisher: Hasanuddin University
Language: en

Abstract

Diabetes mellitus (DM) is a chronic disease that occurs when the body experiences insulin resistance. One of the treatment for DM is by inhibiting the performance of the -glucosidase enzyme which is located on the smooth wall. Indonesia is famous for having various types of herbal plants that are often used as traditional ingredients, one of which is cinnamon (Cinnamomun burman II) which has compounds such as catechins that are useful as antioxidants. This research method a docking simulation, the ligand was downloaded in the Pubmed database and the androgen receptor macromolecule was downloaded in the Protein Data Bank (PDB), the ligand structure preparation, the test ligand docking simulation and the comparison uses the pymol,pyrx program, and Lipinski test, toxicity test using the PREADMET program. The results of binding affinity for the test compound, namely catechin compounds, obtained a binding affinity of -8.0 kcal/mol, while the comparative test, metformin, obtained a binding affinity of -3.3 kcal/mol and Lipinski qualifies as non-carcinogens but can be mutagens. These results indicate that catechin compounds have greater inhibition on alpha glucosidase receptors that cause type 2 diabetes mellitus compared to metformin compounds.

Keywords

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11 authors · 20 co-authorship links

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Co-author	Organisation	Joint articles
Andi Masriah	Affiliation unknown	1
Agus Suryahman	Affiliation unknown	1
Khusnul Khatimah	Affiliation unknown	1
Andi Sompa	Affiliation unknown	1
Haerunnisa Haerunnisa	Affiliation unknown	1
Lukman Daris	Affiliation unknown	1
Wahyuti Wahyuti	Affiliation unknown	1
Andi Nur Apung Massiseng	Affiliation unknown	1
Jaya Jaya	Affiliation unknown	1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/ijoab/oai, first harvested 3 Nov 2026, last seen 3 Nov 2026.

Original metadata (oai_dc)

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	<dc:title xml:lang="en">Antidiabetic Activity of Catechin from Cinnamon (Cinnamomun Burmanii) by Inhibiting Alfa Glucosidase Enzyme </dc:title>
	<dc:creator xml:lang="en">Zaenab, St</dc:creator>
	<dc:creator xml:lang="en">Hasyim, Zohrah </dc:creator>
	<dc:subject xml:lang="en">Diabetes mellitus</dc:subject>
	<dc:subject xml:lang="en">Cinnamomun burmanni</dc:subject>
	<dc:subject xml:lang="en">α-glicosidase</dc:subject>
	<dc:subject xml:lang="en">Catechin</dc:subject>
	<dc:subject xml:lang="en">Docking</dc:subject>
	<dc:subject xml:lang="en">PREADMET</dc:subject>
	<dc:description xml:lang="en">Diabetes mellitus (DM) is a chronic disease that occurs when the body experiences insulin resistance. One of the treatment for DM is by inhibiting the performance of the -glucosidase enzyme which is located on the smooth wall. Indonesia is famous for having various types of herbal plants that are often used as traditional ingredients, one of which is cinnamon (Cinnamomun burman II) which has compounds such as catechins that are useful as antioxidants. This research method a docking simulation, the ligand was downloaded in the Pubmed database and the androgen receptor macromolecule was downloaded in the Protein Data Bank (PDB), the ligand structure preparation, the test ligand docking simulation and the comparison uses the pymol,pyrx program, and Lipinski test, toxicity test using the PREADMET program. The results of binding affinity for the test compound, namely catechin compounds, obtained a binding affinity of -8.0 kcal/mol, while the comparative test, metformin, obtained a binding affinity of -3.3 kcal/mol and Lipinski qualifies as non-carcinogens but can be mutagens. These results indicate that catechin compounds have greater inhibition on alpha glucosidase receptors that cause type 2 diabetes mellitus compared to metformin compounds.</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2022-12-29</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/ijoab/article/view/24796</dc:identifier>
	<dc:source xml:lang="en">International Journal of Applied Biology; Vol. 6 No. 2 (2022): International Journal of Applied Biology; 242-248</dc:source>
	<dc:source>2580-2119</dc:source>
	<dc:source>2580-2410</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/ijoab/article/view/24796/9181</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2022 International Journal of Applied Biology</dc:rights>
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