Cytotoxic Activity of Bioactve Compounds from Hydroid Aglophenia cupressina Lamoureoux against Hela Tumor Cells

Sjafaraenan, Sjafaraenan; Johannes, Eva; Herwin, Herwin

Jurnal

Cytotoxic Activity of Bioactve Compounds from Hydroid Aglophenia cupressina Lamoureoux against Hela Tumor Cells

International Journal of Applied Biology · Vol. 8 No. 1 (2024) · pp. 41–50

ISSN: 2580-2119, 2580-2410
Published: 2024-06-30
Publisher: Hasanuddin University
Language: en

Abstract

Hydroids are marine invertebrates living on sponges, which belong to the phylum Coelenterata. They also contain several chemical compounds, including alkaloids, steroids, terpenoids, and histamine, which can be used as medicinal raw materials, such as antimicrobials and anticancer. Therefore, this study aimed to assess the working mechanism of active compounds obtained from the extract and the fraction of Hydroid Aglaophenia cupressina Lamoureoux against Hela ttumor cell line, as a solvent used n-hexane. The cytotoxic activity was carried out by using MTT method. The results showed both extract and fraction activities against Hela tumor cells. They were also categorized as moderate cytotoxic activity based on the IC50 values of the extract and fraction, namely 0.31726 µg/mL and 0.32712 µg/mL, respectively.

Keywords

Collaboration network of the authors

16 authors · 24 co-authorship links · 4 across different organisations

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Universitas Halu Oleo
Universitas Sulawesi Tenggara
Affiliation unknown

Different organisations
Same organisation
Affiliation unknown
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Co-author	Organisation	Joint articles
Niken Yulian Yusuf	Universitas Sulawesi Tenggara	1
Amir Faisal	Universitas Sulawesi Tenggara	1
Darmin Tuwu	Universitas Halu Oleo	1
Bahtiar Bahtiar	Universitas Halu Oleo	1
Rahim Aka	Universitas Halu Oleo	1
Hamdan Has	Universitas Halu Oleo	1
Ulfah Nur Amaliah	Affiliation unknown	1
Munif S Hasan	Affiliation unknown	1
Elis Tambaru	Affiliation unknown	1
Syahribulan Syahribulan	Affiliation unknown	1
Nur Ramaliani Samsul	Affiliation unknown	1
Evy Noviana Noviana	Affiliation unknown	1
Sjafaraenan	Affiliation unknown	1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/ijoab/oai, first harvested 3 Nov 2026, last seen 3 Nov 2026.

Original metadata (oai_dc)

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	<dc:title xml:lang="en">Cytotoxic Activity of Bioactve Compounds from Hydroid Aglophenia cupressina Lamoureoux against Hela Tumor Cells</dc:title>
	<dc:creator xml:lang="en">Sjafaraenan, Sjafaraenan</dc:creator>
	<dc:creator xml:lang="en">Johannes, Eva</dc:creator>
	<dc:creator xml:lang="en">Herwin, Herwin</dc:creator>
	<dc:subject xml:lang="en">Bioactive compounds</dc:subject>
	<dc:subject xml:lang="en">Cytotoxic</dc:subject>
	<dc:subject xml:lang="en">Hela tumor cells</dc:subject>
	<dc:subject xml:lang="en">Hydroid</dc:subject>
	<dc:description xml:lang="en">Hydroids are marine invertebrates living on sponges, which belong to the phylum Coelenterata. They also contain several chemical compounds, including alkaloids, steroids, terpenoids, and histamine, which can be used as medicinal raw materials, such as antimicrobials and anticancer. Therefore, this study aimed to assess the working mechanism of active compounds obtained from the extract and the fraction of Hydroid Aglaophenia cupressina Lamoureoux against Hela ttumor cell line, as a solvent used n-hexane.  The cytotoxic activity was carried out by using MTT method.  The results showed both extract and fraction activities against Hela tumor cells. They were also categorized as moderate cytotoxic activity based on the IC50 values of the extract and fraction, namely 0.31726 µg/mL and 0.32712 µg/mL, respectively.</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2024-06-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/ijoab/article/view/31098</dc:identifier>
	<dc:source xml:lang="en">International Journal of Applied Biology; Vol. 8 No. 1 (2024): International Journal of Applied Biology; 41-50</dc:source>
	<dc:source>2580-2119</dc:source>
	<dc:source>2580-2410</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/ijoab/article/view/31098/11711</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 International Journal of Applied Biology</dc:rights>
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