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TESTING THE ANTIHYPERGLYCEMIC POTENTIAL OF THE ETHANOL EXTRACT OF PAPUAN ANTS' NESTS (Myrmecodia pendans) ON MENCIT (Mus musculus)

Jurnal Ilmiah Ilmu Terapan Universitas Jambi · Vol. 7 No. 2 (2024) · hlm. 189–197

DOI
10.22437/jiituj.v7i2.31654
ISSN
2580-2259, 2580-2240
Terbit
2024-02-25
Penerbit
LPPM Universitas Jambi
Bahasa
en
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

The use of synthetic drugs has potential pose a risk of complications in sufferers of hyperglycemia. WHO recommends the use of traditional medicine to prevent & treat chronic diseases. The problem formulation includes the effectiveness of the original Papuan EESS test in treating hyperglycemia in mice, with a comparison of results at doses of 100.8 mg/kgBB, 50.4 mg/kgBB, and 25.2 mg/kgBB. This research aims to prove effectiveness of native Papuan EESS in treating hyperglycemia with mice & compare the effectiveness at different doses. The research uses an experimental laboratory design. Male mice aged 2 – 3 months with body weight of 20 – 30 grams, divided into five groups: control + glibenclamide 13.39 mg/kgBW, control - NaCMC 1%, native Papuan EESS treatment dose 100.8 mg/kgBW, 50.4 mg/kgBB, and 25.2 mg/kgBB. Alloxan 4.54 mg/kgBW was administered to create hyperglycemia in mice. Extraction used the maceration method with 70% ethanol solvent. The research results showed that EESS suspension was effective in treating hyperglycemia. The dose of 100.8 mg/kgBB had an average decrease in blood sugar of 122.17 mg/dL, higher than the dose of 50.4 mg/kgBB (decrease of 155.00 mg/dL) and 25.2 mg/kgBB (decrease 200.33mg/dL). In the control group, control + with 13.39 mg/kgBW glibenclamide showed a greater reduction (121.87 mg/dL) than control - with 1% NaCMC (205.83 mg/dL reduction). EESS is native to Papua antihyperglycemia is effective in mice with hyperglycemia. Comparison of the effectiveness of EESS doses showed a significant difference in response.

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14 penulis · 45 tautan kepenulisan bersama · 22 lintas organisasi

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  • Universitas Pendidikan Muhammadiyah Sorong
  • Universitas Ahmad Dahlan
  • Muhammadiyah University of Yogyakarta
  • Universitas Muhamadiyah Sorong
  • Iwaki City Medical Center
  • National Research and Innovation Agency
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Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Akrom AkromUniversitas Ahmad Dahlan2
Titiek HidayatiMuhammadiyah University of Yogyakarta2
Yusran Timang PasuluUniversitas Muhamadiyah Sorong1
Angga Bayu BudiyantoUniversitas Pendidikan Muhammadiyah Sorong1
Nurkhasanah NurkhasanahAfiliasi tidak diketahui1
Ikhwan Dahlan RaisAfiliasi tidak diketahui1
Arif Budi SetiantoUniversitas Ahmad Dahlan1
Prasasti BintarumIwaki City Medical Center1
Laela Hayu NuraniUniversitas Ahmad Dahlan1
Muslih AnwarNational Research and Innovation Agency1
Nanik SulistyaniUniversitas Ahmad Dahlan1

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Sumber metadata: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/JIITUJ/oai, pertama di-harvest 5 Nov 2026, terakhir terlihat 15 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">TESTING THE ANTIHYPERGLYCEMIC POTENTIAL OF THE ETHANOL EXTRACT OF PAPUAN ANTS' NESTS (Myrmecodia pendans) ON MENCIT (Mus musculus)</dc:title>
	<dc:creator xml:lang="en">fania, vikafania</dc:creator>
	<dc:creator xml:lang="en">Hardia, Lukman</dc:creator>
	<dc:creator xml:lang="en">Astuti, Ratih Arum</dc:creator>
	<dc:subject xml:lang="en">Ant Nest (M. Pendans)</dc:subject>
	<dc:subject xml:lang="en">Antihyperglycemia</dc:subject>
	<dc:subject xml:lang="en">Male Mencit</dc:subject>
	<dc:description xml:lang="en">The use of synthetic drugs has potential pose a risk of complications in sufferers of hyperglycemia. WHO recommends the use of traditional medicine to prevent &amp;amp; treat chronic diseases. The problem formulation includes the effectiveness of the original Papuan EESS test in treating hyperglycemia in mice, with a comparison of results at doses of 100.8 mg/kgBB, 50.4 mg/kgBB, and 25.2 mg/kgBB. This research aims to prove effectiveness of native Papuan EESS in treating hyperglycemia with mice &amp;amp; compare the effectiveness at different doses. The research uses an experimental laboratory design. Male mice aged 2 – 3 months with body weight of 20 – 30 grams, divided into five groups: control + glibenclamide 13.39 mg/kgBW, control - NaCMC 1%, native Papuan EESS treatment dose 100.8 mg/kgBW, 50.4 mg/kgBB, and 25.2 mg/kgBB. Alloxan 4.54 mg/kgBW was administered to create hyperglycemia in mice. Extraction used the maceration method with 70% ethanol solvent. The research results showed that EESS suspension was effective in treating hyperglycemia. The dose of 100.8 mg/kgBB had an average decrease in blood sugar of 122.17 mg/dL, higher than the dose of 50.4 mg/kgBB (decrease of 155.00 mg/dL) and 25.2 mg/kgBB (decrease 200.33mg/dL). In the control group, control + with 13.39 mg/kgBW glibenclamide showed a greater reduction (121.87 mg/dL) than control - with 1% NaCMC (205.83 mg/dL reduction). EESS is native to Papua antihyperglycemia is effective in mice with hyperglycemia. Comparison of the effectiveness of EESS doses showed a significant difference in response.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2024-02-25</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/JIITUJ/article/view/31654</dc:identifier>
	<dc:identifier>10.22437/jiituj.v7i2.31654</dc:identifier>
	<dc:source xml:lang="en">Jurnal Ilmiah Ilmu Terapan Universitas Jambi; Vol. 7 No. 2 (2023): Volume 7, Nomor 2, December 2023; 189-197</dc:source>
	<dc:source>2580-2259</dc:source>
	<dc:source>2580-2240</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/JIITUJ/article/view/31654/17945</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 vikafania fania, Lukman Hardia, Ratih Arum Astuti</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>