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BREADFRUIT PEEL AS THE MOST POTENT RADICAL SCAVENGERS FOR SKIN PROTECTION

Jurnal Ilmiah Ilmu Terapan Universitas Jambi · Vol. 8 No. 1 (2024) · pp. 325–333

DOI
10.22437/jiituj.v8i1.33966
ISSN
2580-2259, 2580-2240
Published
2024-06-06
Publisher
LPPM Universitas Jambi
Language
en
License
creativecommons.org/licenses/by/4.0

Abstract

The sun's ultraviolet radiation causes erythema, premature aging, sunburn, hyperpigmentation, inflammation, and dry skin. For this purpose, sunscreen with an SPF value of over 15 is needed to protect the skin against UV rays. Breadfruit peel containing flavonoids may protect against free radicals and UV radiation. This study aims to increase SPF value from breadfruit fractionate by combining niacinamide and alpha-tocopherol. The ABTS and BSLT methods were used to screen potent free radical scavengers in n-hexane, dichloromethane, ethyl acetate, and methanol extracts. The dichloromethane extract had the highest potential as a free radical scavenger, with IC50 20,90 more or less 0,54, and the lowest toxicity, with LC50 234,42 more or less 1,06. Then, the scavenging activities and selective index of fractionates of dichloromethane were evaluated to show that the DM2 fraction had the strongest free radical scavenging activity and the lowest toxicity, with the highest selective index value of 46.08. The main active ingredient was DM2, combined with niacinamide and alpha-tocopherol into five compositions. The results of the lotion dosage forms revealed that the fifth formula, F5, met the requirement SNI standards and was stable during storage, with an SPF value of 20.61 more or less than 0.75, which was three times higher than the positive control with an SPF value of 6.67 more or less 1.28.

Keywords

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12 authors · 25 co-authorship links

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Co-authorOrganisationJoint articles
Syaiful SyaifulAffiliation unknown2
Lizawati LizawatiAffiliation unknown2
Diah Tri UtamiAffiliation unknown2
Aries Bagus SasongkoAffiliation unknown2
Beni Hendro PrabowoAffiliation unknown2
Netrilina NetrilinaAffiliation unknown1
Lailatul AuliahAffiliation unknown1
Eza Permata SariAffiliation unknown1
Uce LestariAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://online-journal.unja.ac.id/index.php/JIITUJ/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">BREADFRUIT PEEL AS THE MOST POTENT RADICAL SCAVENGERS FOR SKIN PROTECTION</dc:title>
	<dc:creator xml:lang="en">Syamsurizal, Syamsurizal</dc:creator>
	<dc:creator xml:lang="en">Elisma, Elisma</dc:creator>
	<dc:creator xml:lang="en">Pratiwi, Puspa Dwi</dc:creator>
	<dc:subject xml:lang="en">ABTS</dc:subject>
	<dc:subject xml:lang="en">Artocarpus Altilis</dc:subject>
	<dc:subject xml:lang="en">BSLT</dc:subject>
	<dc:subject xml:lang="en">Lotion</dc:subject>
	<dc:subject xml:lang="en">Scavenging</dc:subject>
	<dc:subject xml:lang="en">SPF</dc:subject>
	<dc:description xml:lang="en">The sun's ultraviolet radiation causes erythema, premature aging, sunburn, hyperpigmentation, inflammation, and dry skin. For this purpose, sunscreen with an SPF value of over 15 is needed to protect the skin against UV rays. Breadfruit peel containing flavonoids may protect against free radicals and UV radiation. This study aims to increase SPF value from breadfruit fractionate by combining niacinamide and alpha-tocopherol. The ABTS and BSLT methods were used to screen potent free radical scavengers in n-hexane, dichloromethane, ethyl acetate, and methanol extracts. The dichloromethane extract had the highest potential as a free radical scavenger, with IC50 20,90 more or less 0,54, and the lowest toxicity, with LC50 234,42 more or less 1,06. Then, the scavenging activities and selective index of fractionates of dichloromethane were evaluated to show that the DM2 fraction had the strongest free radical scavenging activity and the lowest toxicity, with the highest selective index value of 46.08. The main active ingredient was DM2, combined with niacinamide and alpha-tocopherol into five compositions. The results of the lotion dosage forms revealed that the fifth formula, F5, met the requirement SNI standards and was stable during storage, with an SPF value of 20.61 more or less than 0.75, which was three times higher than the positive control with an SPF value of 6.67 more or less 1.28.</dc:description>
	<dc:publisher xml:lang="en">LPPM Universitas Jambi</dc:publisher>
	<dc:date>2024-06-06</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://online-journal.unja.ac.id/JIITUJ/article/view/33966</dc:identifier>
	<dc:identifier>10.22437/jiituj.v8i1.33966</dc:identifier>
	<dc:source xml:lang="en">Jurnal Ilmiah Ilmu Terapan Universitas Jambi; Vol. 8 No. 1 (2024): Volume 8, Nomor 1, June 2024; 325-333</dc:source>
	<dc:source>2580-2259</dc:source>
	<dc:source>2580-2240</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://online-journal.unja.ac.id/JIITUJ/article/view/33966/18196</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Syamsurizal Syamsurizal, Elisma Elisma, Puspa Dwi Pratiwi</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>