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Sintesis 4-Hidroksisinamamida dari Asam 4-Hidroksinanamat melalui Reaksi Esterifikasi dan Amonolisis

Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) · Vol. ume No. 2 (2009) · pp. 37–43

DOI
10.70561/ica.v2i2.2463
ISSN
2655-6049, 2085-014X
Published
2009-12-01
Publisher
Hasanuddin University
Language
en

Abstract

The 4-hydroxycinnamamide is a compound that has been isolated from the root bark of Kleinhovia hospita Linn. The compound show high toxicity to Artemia salina Leach (IC 180,53 µg) so it can be expected has cytostatic activity against P388 leukemic cells. However, the concentration of the compound in the root bark of K. hospita Linn is very low (about 1.6 ppm), and commercially the compound is not ready and has never been synthesized. Therefore, it is important to find out a synthesis method to used in prepare the compound for further examination, in particular its cytostatic activity. By this research, the 4-hydroxycinnamamide compound has been prepared from 4- hydroxycinnamic acid via esterification reaction with excess ethanol and sulphate acid catalyst followed ammonolysis reaction with concentrated ammonia. The esterification stage gave ethyl 4-hidroxycinnamate as white crystall with melting point 133-134oC and 34.9% yield, and the ammonolysis stage gave 4-hydroxycinnamamide as white crystall with merting point 140oC and 46.1% yield. Identification of the reaction product was carried out by FTIR and NMR spectroscopy methods.Keywords: 4-hydroxycinnamamide, 4-hydroxycinnamic acid, esterification, ammonolysis

Collaboration network of the authors

40 authors · 92 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Adri AdriAffiliation unknown8
Suharyon SuharyonAffiliation unknown5
Erwin AnshariAffiliation unknown4
DIKI KURNIAWANAffiliation unknown3
Abdul Wahid WahabAffiliation unknown3
Hasnah NatsirAffiliation unknown3
Wd Rizky AwaliahAffiliation unknown2
Nursiah La NafieAffiliation unknown2
Nur Imdah MinsyahAffiliation unknown2
Syafri EdiAffiliation unknown2
Paulina TabaAffiliation unknown2
Musrifah TaharAffiliation unknown2
Almin AlminAffiliation unknown1
Muhammad AchidaAffiliation unknown1
Laode Muhammad BuyungAffiliation unknown1
Ali ArsadAffiliation unknown1
Hasnawati HasnawatiUniversitas Halu Oleo1
Marwan Zam MiliAffiliation unknown1
Wahab WahabUniversitas Halu Oleo1
Alfian Hendra SaputraAffiliation unknown1
Deniyatno DeniyatnoAffiliation unknown1
La Ode ResteleAffiliation unknown1
Hasria HasriaAffiliation unknown1
Muliddin MuliddinAffiliation unknown1
Ali OktoUniversitas Halu Oleo1
Suparwi SuparwiAffiliation unknown1
Ade SaputraAffiliation unknown1
Ritna WahyuniAffiliation unknown1
Dhanu Bagas PratomoAffiliation unknown1
FEBI ADRIANA MUTIARA SOGALREYAffiliation unknown1
Komari KomariAffiliation unknown1
Febi Adriana MutiaraAffiliation unknown1
SalahudinAffiliation unknown1
Onnie LumintangAffiliation unknown1
Mustari MustariAffiliation unknown1
M Maulana Kurnia PratamaAffiliation unknown1
Raditya Janaloka NatishareviAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/ica/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">Sintesis 4-Hidroksisinamamida dari Asam 4-Hidroksinanamat melalui Reaksi Esterifikasi dan Amonolisis</dc:title>
	<dc:creator xml:lang="en">Firdaus, Firdaus</dc:creator>
	<dc:creator xml:lang="en">Hariani Soekamto, Nunuk</dc:creator>
	<dc:creator xml:lang="en">Karim, Abdul</dc:creator>
	<dc:description xml:lang="en">The 4-hydroxycinnamamide  is a compound  that has been isolated from the root bark of Kleinhovia hospita Linn. The compound show high toxicity to Artemia salina Leach (IC 180,53 µg) so it can be expected has cytostatic activity against P388 leukemic cells. However, the concentration of the compound in the root bark of K. hospita Linn is very low (about 1.6 ppm), and commercially the compound  is  not  ready  and  has  never  been  synthesized.  Therefore,  it  is  important  to  find  out  a synthesis method to used in prepare the compound for further examination, in particular its cytostatic activity. By this research, the 4-hydroxycinnamamide compound has been prepared from 4- hydroxycinnamic  acid  via  esterification  reaction  with  excess  ethanol  and  sulphate  acid  catalyst followed  ammonolysis  reaction  with concentrated  ammonia.  The esterification  stage  gave  ethyl 4-hidroxycinnamate   as  white  crystall  with  melting  point  133-134oC   and  34.9%  yield,  and  the ammonolysis stage gave 4-hydroxycinnamamide as white crystall with merting point 140oC and 46.1% yield. Identification of the reaction product was carried out by FTIR and NMR spectroscopy methods.Keywords: 4-hydroxycinnamamide, 4-hydroxycinnamic acid, esterification, ammonolysis</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2009-12-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/ica/article/view/2463</dc:identifier>
	<dc:identifier>10.70561/ica.v2i2.2463</dc:identifier>
	<dc:source xml:lang="en">Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta); Volume 2 No 2 - December 2009; 37-43</dc:source>
	<dc:source>2655-6049</dc:source>
	<dc:source>2085-014X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/ica/article/view/2463/1331</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2017 Indonesia Chimica Acta</dc:rights>
</oai_dc:dc>