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STUDY OF COMPOUNDS FROM EXTRACT OF Melochia umbellata (Houtt.) Stapf var. Degrabrata K. (PALIASA) LEAVES THAT HAS POTENTIAL AS ANTIBACTERIAL

Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) · Vol. ume No. 1 (2015) · pp. 1–9

DOI
10.70561/ica.v8i1.2472
ISSN
2655-6049, 2085-014X
Published
2015-06-01
Publisher
Hasanuddin University
Language
en

Abstract

Determination of antibacterial activity of each extract of M. umbellata (Houtt.) Stapf var. K. degrabrata leaves has been conducted against three strains bacteria Escherichia coli, Staphylococcus aureus, and Shigella dysenteriae by using amoxicillin as a positive control and DMSO as a negative control. Agar diffusion method has been used with MHA medium (Muller Hinton Agar) on variation concentrations of each extract were 2500 ppm, 5000 ppm, 10,000 ppm, and 20,000 ppm N-hexane extract was the most active extract against S. aureus with zone of inhibitions were 10.50 mm, 10.80 mm, 11.00 mm and 11.45 mm, respectively. The most active extract against S. dysenteriae was ethyl acetate extracts with zone of inhibitions were 9.36 mm, 11.55 mm, 11.58 mm and 17.70 mm, respectively. Isolated compound from n-hexane extract was first compound as white powder with a melting point of 75-77 °C which was identified as 1-Tetracosanol and second compound was obtained in the form of a yellow paste which was identified as steroid compound that had long conjugated substituent. These compounds were elucidated based on the data of IR, UV-Vis, 1H-NMR, and 13C-NMR.

Keywords

Collaboration network of the authors

40 authors · 101 co-authorship links · showing the 40 most connected

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  • Universitas Halu Oleo
  • Affiliation unknown
  • Different organisations
  • Same organisation
  • Affiliation unknown
  • Thicker line = more joint articles · bigger circle = more articles
Show as table
Co-authorOrganisationJoint articles
Adri AdriAffiliation unknown8
Seniwati DaliAffiliation unknown7
Suharyon SuharyonAffiliation unknown5
Erwin AnshariAffiliation unknown4
Ahyar AhmadAffiliation unknown4
Abdur Rahman ArifAffiliation unknown3
ABDUL KARIMAffiliation unknown3
Wd Rizky AwaliahAffiliation unknown2
Nur Imdah MinsyahAffiliation unknown2
Syafri EdiAffiliation unknown2
Muawanah MuawanahAffiliation unknown2
Sartika DanialAffiliation unknown2
Muhammad ZakirAffiliation unknown2
Hanapi UsmanAffiliation unknown2
Paulina TabaAffiliation unknown2
Musrifah TaharAffiliation unknown2
Almin AlminAffiliation unknown1
Muhammad AchidaAffiliation unknown1
Laode Muhammad BuyungAffiliation unknown1
Ali ArsadAffiliation unknown1
Hasnawati HasnawatiUniversitas Halu Oleo1
Marwan Zam MiliAffiliation unknown1
Wahab WahabUniversitas Halu Oleo1
Alfian Hendra SaputraAffiliation unknown1
Deniyatno DeniyatnoAffiliation unknown1
La Ode ResteleAffiliation unknown1
Hasria HasriaAffiliation unknown1
Muliddin MuliddinAffiliation unknown1
Ali OktoUniversitas Halu Oleo1
Suparwi SuparwiAffiliation unknown1
Ade SaputraAffiliation unknown1
Ritna WahyuniAffiliation unknown1
Dhanu Bagas PratomoAffiliation unknown1
Raditya Janaloka NatishareviAffiliation unknown1
Jose RizalAffiliation unknown1
Pepi NoviantiAffiliation unknown1

Affiliations come from OpenAlex; journal OAI-PMH metadata carries none. Authors without an OpenAlex ID are matched by name, which can merge or split people.

Metadata source: OAI-PMH (metadata jurnal) https://journal.unhas.ac.id/index.php/ica/oai, first harvested 5 Nov 2026, last seen 5 Nov 2026.
Original metadata (oai_dc) 
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	<dc:title xml:lang="en">STUDY OF COMPOUNDS FROM EXTRACT OF Melochia umbellata (Houtt.) Stapf var. Degrabrata K. (PALIASA) LEAVES THAT HAS POTENTIAL AS ANTIBACTERIAL</dc:title>
	<dc:creator xml:lang="en">Wullur, Selfi</dc:creator>
	<dc:creator xml:lang="en">Firdaus, Firdaus</dc:creator>
	<dc:creator xml:lang="en">Natsir, Hasnah</dc:creator>
	<dc:creator xml:lang="en">Hariani Soekamto, Nunuk</dc:creator>
	<dc:subject xml:lang="en">1-Tetracosanol</dc:subject>
	<dc:subject xml:lang="en">antibacterial</dc:subject>
	<dc:subject xml:lang="en">phytochemical</dc:subject>
	<dc:subject xml:lang="en">Melochia umbellata</dc:subject>
	<dc:subject xml:lang="en">steroid</dc:subject>
	<dc:description xml:lang="en">Determination of antibacterial activity of each extract of M. umbellata (Houtt.) Stapf var. K. degrabrata leaves has been conducted against three strains bacteria Escherichia coli, Staphylococcus aureus, and Shigella dysenteriae by using amoxicillin as a positive control and DMSO as a negative control. Agar diffusion method has been used with MHA medium (Muller Hinton Agar) on variation concentrations of each extract were 2500 ppm, 5000 ppm, 10,000 ppm, and 20,000 ppm N-hexane extract was the most active extract against S. aureus with zone of inhibitions were 10.50 mm, 10.80 mm, 11.00 mm and 11.45 mm, respectively. The most active extract against S. dysenteriae was ethyl acetate extracts with zone of inhibitions were 9.36 mm, 11.55 mm, 11.58 mm and 17.70 mm, respectively. Isolated compound from n-hexane extract was first compound as white powder with a melting point of 75-77 °C which was identified as 1-Tetracosanol and second compound was obtained in the form of a yellow paste which was identified as steroid compound that had long conjugated substituent. These compounds were elucidated based on the data of IR, UV-Vis, 1H-NMR, and 13C-NMR.</dc:description>
	<dc:publisher xml:lang="en">Hasanuddin University</dc:publisher>
	<dc:date>2015-06-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.unhas.ac.id/index.php/ica/article/view/2472</dc:identifier>
	<dc:identifier>10.70561/ica.v8i1.2472</dc:identifier>
	<dc:source xml:lang="en">Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta); Volume 8 No 1 - June 2015; 1-9</dc:source>
	<dc:source>2655-6049</dc:source>
	<dc:source>2085-014X</dc:source>
	<dc:language>en</dc:language>
	<dc:relation>https://journal.unhas.ac.id/index.php/ica/article/view/2472/1340</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2017 Indonesia Chimica Acta</dc:rights>
</oai_dc:dc>